Impact of COVID-19 on disinfectant exposure and associated health effects.

COVID-19 对消毒剂接触和相关健康影响的影响。

• 批准号: 10400556
• 负责人: Soo-Jeong Lee
• 金额: $ 24.23万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10400556
• 关键词: 2019-nCoV; Address; Affect; Age; Allergic; Ammonium Chloride; Animals; Area; Asthma; Bacterial Artificial Chromosomes; Benzalkonium Chloride; Biological; Biological Markers; Biological Monitoring; Blood; Body Burden; COVID-19; COVID-19 pandemic; California; Cells; Characteristics; Chemicals; Chinese People; Cholesterol; Communities; Community Health; Community Workers; Data; Data Sources; Detection; Disinfectants; Disinfection; Epidemiology; Excretory function; Exposure to; Eye; Feces; Foundations; Future; Gender; General Population; Hazardous Chemicals; Health; Health Personnel; Health system; Hispanics; Home; Hospitals; Human; Incidence; Infection Control; Infection prevention; Inflammation; Link; Measurement; Measures; Mitochondria; National Institute of Environmental Health Sciences; Nervous system structure; Occupational; Occupational Exposure; Occupational Groups; Occupations; Organ; Participant; Patient Self-Report; Perception; Pesticides; Pilot Projects; Poison; Policies; Population; Public Health; Pulmonary Inflammation; Rattus; Reporting; Reproduction; Research; Respiratory System; Risk; Route; SARS-CoV-2 infection; Sampling; Skin; Surface; Surveillance Program; Surveys; Symptoms; Time; Universities; Urine; Workplace; base; comorbidity; experience; exposed human population; follow-up; health care settings; healthy volunteer; high risk population; immune function; improved; irritation; microorganism; novel strategies; pandemic disease; pathogen; prevent; preventive intervention; quaternary ammonium compound; response; substance use; surveillance study; transmission process; trend

PROJECT SUMMARY/ABSTRACT Disinfectants are widely used in various products and in various settings to prevent infection and transmission of harmful pathogens. Disinfectants, however, contain hazardous chemicals and are known to cause irritation or allergic symptoms in eyes, skin, respiratory and nervous systems, asthma, and damage to organs with prolonged or repeated exposure. Quaternary ammonium compounds (QACs) are the most common active ingredients used in disinfectants approved for SARS-CoV-2 control. The coronavirus disease 2019 (COVID-19) pandemic led to dramatically increased use of disinfectants in the community and workplaces to prevent SARS-CoV-2 infection and transmission. Such increased use of disinfectants raises substantial concerns regarding the health effects of disinfectants. As for health risk by disinfectants, cleaning workers, particularly in healthcare settings, have been identified as occupational groups most affected by disinfectants. During the COVID-19 pandemic, with the heightened need for infection control in healthcare settings as well as increased use of disinfectants at home/community, these workers may have further increased health risks from disinfectant exposure. The purpose of this study is to assess the impact of the COVID-19 pandemic on disinfectant use and the incidence of disinfectant-related illness and examine the association between disinfectant exposure and health symptoms. We propose a study using three approaches: (1) Analysis of California Pesticide Illness Surveillance Program data (2011-2020) to investigate disinfectant-related illness cases in California. (2) A survey of 300 cleaning staff (predominantly Chinese and Hispanic) in a university health system in Northern California on disinfectant use and chemical-related health symptoms. (3) Measurement of two common QACs (benzalkonium chloride [BAC] and didecyl dimethyl ammonium chloride [DDAC]) in feces and urine in a subset of survey participants (n=100). The study has the following specific aims: (1) Characterize disinfectant-related illness cases in California during 2011-2020 and examine the trend of the annual incidence over time. (2) Characterize disinfectant use during COVID-19 among hospital cleaning staff and examine the relationship of disinfectant use with self-reported health symptoms. (3) Measure QACs (BAC/DDAC) in feces and urine among hospital cleaning staff and examine their associations with self- reported disinfectant use and health symptoms. This study will produce helpful information to assess the public health burden by the widely used disinfectants and the impact of COVID-19 on disinfectant exposure and health problems among the general population as well as the high-risk group of hospital cleaning staff. This study will be one of the first studies that measures and quantifies QACs in human samples to examine health effects. The biological data on QAC exposure among hospital cleaning staff will capture the body burden of disinfectant chemicals from both occupational and non-occupational exposures that increased during the COVID-19 pandemic, and will serve as a valuable foundation for analyses of longer-term health effects.

项目总结/摘要 消毒剂广泛用于各种产品和各种环境中，以防止感染和传播 有害的病原体。然而，消毒剂含有危险化学物质，并且已知会引起刺激 或眼睛、皮肤、呼吸系统和神经系统的过敏症状，哮喘， 长期或反复暴露。季铵化合物（QAC）是最常见的活性物质， 用于控制SARS-CoV-2的消毒剂中使用的成分。2019冠状病毒病（COVID-19） 大流行导致社区和工作场所消毒剂的使用急剧增加，以防止 SARS-CoV-2感染与传播消毒剂使用的增加引起了人们的严重关切 关于消毒剂对健康的影响至于消毒剂对健康的危害，清洁工人，特别是在 卫生保健机构被确定为受消毒剂影响最大的职业群体。期间 2019冠状病毒病大流行，医疗机构对感染控制的需求增加， 在家庭/社区使用消毒剂，这些工人可能会进一步增加健康风险， 消毒剂暴露。本研究旨在评估COVID-19大流行对 消毒剂使用与消毒剂相关疾病的发生率，并检查 消毒剂暴露和健康症状。我们提出了一个研究使用三种方法：（1）分析 加州农药疾病监测项目数据（2011-2020年），用于调查消毒剂相关疾病 加州的案件。(2)对某大学300名保洁员（主要是华裔和西班牙裔）的调查 加州北方卫生系统消毒剂使用和化学相关健康症状。（三） 两种常见QAC（苯扎氯铵[BAC]和二癸基二甲基氯化铵）的测量 [DDAC]）在调查参与者的子集（n=100）的粪便和尿液中。该研究具有以下具体 目的：（1）描述2011-2020年加州消毒相关疾病病例的特征，并研究其趋势 每年的发病率。(2)描述COVID-19期间医院清洁中消毒剂的使用情况 工作人员和检查消毒剂的使用与自我报告的健康症状的关系。(3)测量QAC (BAC/DDAC）的粪便和尿液中的医院清洁人员，并检查其与自我- 使用消毒剂和健康症状。这项研究将提供有用的信息，以评估公众 广泛使用的消毒剂造成的健康负担以及COVID-19对消毒剂暴露的影响， 一般人群以及医院清洁人员这一高危群体的健康问题。这 这项研究将是首批测量和量化人体样本中QAC以检查健康状况的研究之一 方面的影响.医院清洁人员接触质保局产品的生物学数据将反映以下物质的身体负担： 职业和非职业接触的消毒化学品， 新冠肺炎疫情，并将作为分析长期健康影响的宝贵基础。