International epidemiology Databases to Evaluate AIDS (IeDEA) Southern Africa.

评估艾滋病的国际流行病学数据库 (IeDEA) 南部非洲。

• 批准号: 10404615
• 负责人: Mary-Ann Davies
• 金额: $ 406.39万
• 依托单位: UNIVERSITAT BERN
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10404615
• 关键词: 2019-nCoV; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adolescent and Young Adult; Adult; Adverse event; Affect; Africa; Africa South of the Sahara; African; Anti-Retroviral Agents; Breast Feeding; COVID-19; COVID-19 pandemic; COVID-19 pandemic effects; Caring; Cervical Cancer Screening; Child; Clinical; Collaborations; Data; Data Collection; Data Linkages; Databases; Devices; Diagnosis; Diagnostic; Disease; Drug resistance; Drug resistance in tuberculosis; Epidemic; Epidemiology; European; Evaluation; Funding; Goals; HIV; HIV Seronegativity; HIV/TB; Hand; Health; Health Services; Health care facility; Health system; Hepatitis B; Hepatitis B Virus; Incidence; Individual; Infant; Infection; International; Joints; Leadership; Life Cycle Stages; Life Expectancy; Liver; Lung diseases; Malignant Neoplasms; Mental Health; Mentorship; Metabolic; Methods; Modeling; Monitor; Outcome; Outcome Study; Output; Persons; Pharmaceutical Preparations; Policies; Pregnant Women; Prevalence Study; Prevention; Prevention program; Prevention strategy; Private Sector; Public Health; Pulmonary Tuberculosis; Quality of life; Regimen; Registries; Research; Research Personnel; Resistance; Risk; Risk Factors; SARS-CoV-2 transmission; Safety; Sentinel; Services; Sexually Transmitted Diseases; South Africa; South African; Southern Africa; Sputum; Statistical Models; Substance Use Disorder; Sustainable Development; Time; Translating; Treatment outcome; Tuberculosis; United Nations; United States; Universities; Viral; Woman; Work; World Health Organization; antiretroviral therapy; base; cancer care; cancer diagnosis; cancer health disparity; cancer prevention; cardiometabolic risk; cervical cancer prevention; co-infection; cohort; cost effective; data centers; data harmonization; digital; efavirenz; epidemiology study; gender equity; genome sequencing; health care settings; health data; implementation science; improved; improved outcome; in utero; innovation; low and middle-income countries; mathematical model; mortality; negative affect; new technology; novel; open data; point of care; pre-exposure prophylaxis; prevent; programs; resilience; screening; screening program; sequencing platform; social; substance use; targeted sequencing; therapy duration; tool; transmission process; treatment program; tuberculosis drugs; tuberculosis treatment; uptake

Southern Africa is the epicenter of the HIV and tuberculosis (TB) epidemic, and South Africa is at the center of the COVID-19 pandemic in Africa. There is an urgent need for robust epidemiology and implementation science to address the interacting burdens of HIV, TB, and other (emerging) coinfections and non-communicable diseases (NCDs). The International epidemiology Databases to Evaluate AIDS in Southern Africa (IeDEA-SA) has defined six specific aims for the fourth funding period (IeDEA-SA IV): (1) to study outcomes along the continuum of HIV care in adults; (2) to study outcomes in pregnant women, infants, children, and adolescents; (3) to study NCDs, hepatitis B and sexually transmitted infections (STIs); (4) to study the clinical and public health epidemiology of TB; (5) to study cancer prevention, burden, and care; and (6) to study mental health and substance use disorders. Further, we defined six cross-cutting themes: (i) the impact of the COVID-19 pandemic on health services; (ii) gender equity; (iii) capacity building; (iv) digital transformation; (v) open science; and (vi) the United Nations Sustainable Development Goals, which we will develop and prioritize within each aim. Innovations include the addition of the Western Cape Provincial Health Data Centre (WC PHDC), the South African HIV Cancer Match study, the establishment of pre-Exposure prophylaxis cohorts, and the evaluation of novel technologies (for example, a point-of-care genome-sequencing device, a hand-held colposcopic device for cervical cancer screening, or tools to study the transmission of TB in the health care setting) and novel statistical and mathematical modeling approaches. Multiregional Sentinel Research Networks (NCD-Sentinel Research Network [SRN], TB-SRN, Adolescent and Young Adult Network of IeDEA) on NCDs, TB, and adolescents and youth will harmonize data collection across the six IeDEA regions in low- and middle-income countries. The Fogarty-IeDEA Mentorship Program will strengthen capacity building among early-stage investigators. IeDEA-SA now follows nearly 1.3 million people living with HIV, including 285,000 individuals from the private sector (the Aid for AIDS program AfA), and 370,000 with ART duration > ten years. IeDEA IV will add data from 600,000 HIV-negative people through AfA and information from up to 4 million HIV-negative individuals from the WC PHDC in specific analyses. Within IeDEA, the Southern African region includes by far the largest number of adults and children. The COVID-19 pandemic now highlights the importance of epidemiologic research and implementation science across the health system. IeDEA-SA is well- placed to address the specific aims and cross-cutting themes outlined in this application, through its successful track-record of collaboration between the scientific and operational leadership at the Universities of Bern and Cape Town, partnership with several African universities (including the Kwazulu-Natal Research Innovation and Sequencing Platform), United States and European universities, and with the World Health Organization and the Joint United Nations Programme on HIV/AIDS.

南部非洲是艾滋病毒和结核病（TB）流行的中心，南非是艾滋病的中心。 非洲的COVID-19大流行。迫切需要强大的流行病学和实施科学 解决艾滋病毒、结核病和其他（新出现的）合并感染和非传染性疾病的相互影响的负担 非传染性疾病（NCDs）。评价南部非洲艾滋病的国际流行病学数据库（IeDEA-SA） 为第四个资助期（IeDEA-SA IV）确定了六个具体目标：（1）研究成果沿着 成人艾滋病护理的连续性;（2）研究孕妇、婴儿、儿童和青少年的结局; (3)研究非传染性疾病、B型肝炎和性传播感染;（4）研究临床和公共卫生 结核病流行病学;（5）研究癌症预防、负担和护理;（6）研究心理健康和 药物使用障碍。此外，我们界定了六个跨领域主题：（i）COVID-19的影响 大流行病对卫生服务的影响; ㈡性别平等; ㈢能力建设; ㈣数字化转型; ㈤开放科学; 和（vi）联合国可持续发展目标，我们将在每个目标中制定并优先考虑这些目标 瞄准创新措施包括增设西开普省卫生数据中心， 南非艾滋病毒癌症匹配研究，建立暴露前预防队列， 新技术的评估（例如，即时基因组测序设备，手持 阴道镜设备宫颈癌筛查，或工具，以研究结核病的传播在卫生保健 设置）和新颖的统计和数学建模方法。多区域哨兵研究 网络（非传染性疾病哨兵研究网络、结核病哨兵研究网络、 关于非传染性疾病、结核病以及青少年和青年的国际数据交换所（IeDEA）将在以下六个区域协调数据收集工作： 低收入和中等收入国家。Fogarty-IeDEA导师计划将加强能力建设 在早期的研究者中。IeDEA-SA目前跟踪了近130万艾滋病毒感染者，包括 285，000人来自私营部门（艾滋病援助计划AfA），370，000人接受抗逆转录病毒治疗> 十年IEDEA IV将通过AfA增加60万艾滋病毒阴性者的数据， 在具体分析中，来自WC PHDC的100万艾滋病毒阴性个体。在IEDEA内部，南部非洲 该地区的成人和儿童人数最多。2019冠状病毒病疫情凸显了 流行病学研究和实施科学在整个卫生系统的重要性。IEDEA-SA是好的- 通过其成功的实施， 伯尔尼大学的科学和业务领导层之间的合作记录， 开普敦，与几所非洲大学（包括夸祖鲁-纳塔尔研究创新学院）建立伙伴关系 和测序平台），美国和欧洲的大学，并与世界卫生组织 和联合国艾滋病毒/艾滋病联合规划署。