International epidemiology Databases to Evaluate AIDS (IeDEA) Southern Africa.

评估艾滋病的国际流行病学数据库 (IeDEA) 南部非洲。

• 批准号: 10240757
• 负责人: Mary-Ann Davies
• 金额: $ 340万
• 依托单位: UNIVERSITAT BERN
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10240757
• 关键词: 2019-nCoV; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adolescent and Young Adult; Adult; Adverse event; Affect; Africa; Africa South of the Sahara; African; Anti-Retroviral Agents; Breast Feeding; COVID-19; COVID-19 pandemic; Caring; Cervical Cancer Screening; Child; Clinical; Collaborations; Data; Data Collection; Data Linkages; Databases; Devices; Diagnosis; Diagnostic; Disease; Drug resistance; Drug resistance in tuberculosis; Epidemic; Epidemiology; European; Evaluation; Funding; Goals; HIV; HIV Seronegativity; HIV/TB; Hand; Health; Health Services; Health care facility; Health system; Hepatitis B; Hepatitis B Virus; Incidence; Individual; Infant; Infection; International; Joints; Leadership; Life Cycle Stages; Life Expectancy; Liver; Lung diseases; Malignant Neoplasms; Mental Health; Mentorship; Metabolic; Methods; Modeling; Monitor; Outcome; Outcome Study; Output; Pharmaceutical Preparations; Policies; Pregnant Women; Prevalence Study; Prevention; Prevention program; Prevention strategy; Private Sector; Public Health; Pulmonary Tuberculosis; Quality of life; Regimen; Registries; Research; Research Personnel; Resistance; Risk; Risk Factors; SARS-CoV-2 transmission; Safety; Sentinel; Services; Sexually Transmitted Diseases; South Africa; South African; Southern Africa; Sputum; Statistical Models; Substance Use Disorder; Sustainable Development; Time; Translating; Treatment outcome; Tuberculosis; United Nations; United States; Universities; Viral; Woman; Work; World Health Organization; antiretroviral therapy; base; cancer care; cancer diagnosis; cancer health disparity; cancer prevention; cardiometabolic risk; cervical cancer prevention; co-infection; cohort; cost effective; data centers; data harmonization; digital; efavirenz; epidemiology study; gender equity; genome sequencing; health care settings; health data; implementation science; improved; improved outcome; in utero; innovation; low and middle-income countries; mathematical model; mortality; negative affect; new technology; novel; open data; point of care; pre-exposure prophylaxis; prevent; programs; resilience; screening; screening program; sequencing platform; social; substance use; targeted sequencing; therapy duration; tool; transmission process; treatment program; tuberculosis drugs; tuberculosis treatment; uptake

Southern Africa is the epicenter of the HIV and tuberculosis (TB) epidemic, and South Africa is at the center of the COVID-19 pandemic in Africa. There is an urgent need for robust epidemiology and implementation science to address the interacting burdens of HIV, TB, and other (emerging) coinfections and non-communicable diseases (NCDs). The International epidemiology Databases to Evaluate AIDS in Southern Africa (IeDEA-SA) has defined six specific aims for the fourth funding period (IeDEA-SA IV): (1) to study outcomes along the continuum of HIV care in adults; (2) to study outcomes in pregnant women, infants, children, and adolescents; (3) to study NCDs, hepatitis B and sexually transmitted infections (STIs); (4) to study the clinical and public health epidemiology of TB; (5) to study cancer prevention, burden, and care; and (6) to study mental health and substance use disorders. Further, we defined six cross-cutting themes: (i) the impact of the COVID-19 pandemic on health services; (ii) gender equity; (iii) capacity building; (iv) digital transformation; (v) open science; and (vi) the United Nations Sustainable Development Goals, which we will develop and prioritize within each aim. Innovations include the addition of the Western Cape Provincial Health Data Centre (WC PHDC), the South African HIV Cancer Match study, the establishment of pre-Exposure prophylaxis cohorts, and the evaluation of novel technologies (for example, a point-of-care genome-sequencing device, a hand-held colposcopic device for cervical cancer screening, or tools to study the transmission of TB in the health care setting) and novel statistical and mathematical modeling approaches. Multiregional Sentinel Research Networks (NCD-Sentinel Research Network [SRN], TB-SRN, Adolescent and Young Adult Network of IeDEA) on NCDs, TB, and adolescents and youth will harmonize data collection across the six IeDEA regions in low- and middle-income countries. The Fogarty-IeDEA Mentorship Program will strengthen capacity building among early-stage investigators. IeDEA-SA now follows nearly 1.3 million people living with HIV, including 285,000 individuals from the private sector (the Aid for AIDS program AfA), and 370,000 with ART duration > ten years. IeDEA IV will add data from 600,000 HIV-negative people through AfA and information from up to 4 million HIV-negative individuals from the WC PHDC in specific analyses. Within IeDEA, the Southern African region includes by far the largest number of adults and children. The COVID-19 pandemic now highlights the importance of epidemiologic research and implementation science across the health system. IeDEA-SA is well- placed to address the specific aims and cross-cutting themes outlined in this application, through its successful track-record of collaboration between the scientific and operational leadership at the Universities of Bern and Cape Town, partnership with several African universities (including the Kwazulu-Natal Research Innovation and Sequencing Platform), United States and European universities, and with the World Health Organization and the Joint United Nations Programme on HIV/AIDS.

南部非洲是艾滋病毒和结核病流行的中心，而南非处于中心