Administrative Core

项目总结(APOE U19核心A：管理核心) 行政核心将通过提供行政、财政和科学监督来领导这一U19项目 以及促进所有核心和项目的协同作用，以解决ApoE级联假说。核心A将服务于 几个功能，以促进这一U19的科学目标和严谨性。它还将服务于更广泛的 通过门户网站共享知识、资源和数据集，并通过促进 通过年度ApoE研讨会进行协作。核心A将与NIA的倡议充分合作， 敬业的领导团队和具有相关经验的管理人员。作为此U19的联席PIS Core A的项目和联合负责人Bu国军博士(Mayo Clinic Jacksonville)和David Holtzman (圣路易斯华盛顿大学)是载脂蛋白E领域公认的领导者；每个人都有超过25年的 研究载脂蛋白E和载脂蛋白E受体的经验，因为它们与AD和其他衰老的发病机制有关 相关条件。Bu博士和Holtzman博士有着悠久的合作历史，并处于很好的地位来分享 这两个协调机构对U19项目的领导作用。他们也有强大的领导力 分别担任阿尔茨海默病研究部主任和副主任的经历 在他们各自的机构里。与艾莉森·戈特博士一起，他将担任伊坎的现场-PI 在西奈山医学院，他们将通过追求 以下目标：目标1：为U19提供行政结构、财政监督和现场协调 程序。目标2：通过确保负责任地承担U19活动的质量控制责任 进行研究、研究实践的严格性和可重复性，并确保遵守所有 内部和外部监管要求。推广和跟踪开放获取出版物，并促进 向国家卫生研究院提交进度报告。目标3：促进U19的科学指导和融合 通过组织内部指导委员会和外部咨询委员会的会议，构成部分。目标 4：开发和维护apoE网站，作为知识门户以及资源和数据共享 站台。目标5：为U19研究人员以及更广泛的科学界组织年度ApoE研讨会 社区互动和分享研究成果。这些创新的目标将确保 U19团队调查人员的严谨努力将导致新的发现，为治疗策略提供参考。

PROJECT SUMMARY (APOE U19 Core A: Administrative Core) The Administrative Core will lead this U19 project by providing administrative, fiscal, and scientific oversight and promoting synergy of all Cores and Projects to address the ApoE Cascade Hypothesis. Core A will serve several functions to facilitate the scientific objectives and rigor of this U19. It will also serve the broader scientific community by sharing knowledge, resources, and datasets through a web portal and by promoting collaboration through an annual ApoE Symposium. Core A will cooperate fully with NIA initiatives with a dedicated leadership team and administrative personnel with relevant experience. As the Co-PIs of this U19 project and Co-Leaders of Core A, Drs. Guojun Bu (Mayo Clinic Jacksonville) and David Holtzman (Washington University in St. Louis) are recognized leaders in the apoE field; each has more than 25 years of experience studying apoE and apoE receptors as they relate to the pathogenesis of AD and other aging- related conditions. Drs. Bu and Holtzman have a long history of collaboration and are well positioned to share leadership roles for this U19 program at the two coordinating institutions. They also have strong leadership experience each serving as a Department Chair and an Associate Director of Alzheimer’s Disease Research Center at their respective institution. Together with Dr. Alison Goate, who will serve as the Site-PI at Icahn School of Medicine at Mount Sinai, they will ensure integration and synergy across the U19 by pursuing the following aims: Aim 1: Provide administrative structure, fiscal oversight, and site coordination for the U19 program. Aim 2: Assume responsibility for the quality control of the U19 activities by ensuring responsible conduct of research, rigor, and reproducibility of research practices, and by ensuring compliance with all internal and external regulatory requirements. Promote and track open-access publications and facilitate submission of progress reports to NIH. Aim 3: Promote the scientific direction and integration of the U19 components by organizing meetings of the Internal Steering Committee and External Advisory Committee. Aim 4: Develop and maintain an apoE website what will serve as knowledge portal, and resource and data sharing platform. Aim 5: Organize Annual ApoE Symposium for U19 investigators as well as the broader scientific community to interact and share research findings. These innovative aims will ensure that the robust and rigorous efforts by the U19 team investigators will lead to new discoveries to inform therapeutic strategies.