Data Management and Statistical Core

数据管理和统计核心-总结/摘要 数据管理和统计核心（数据核心）提供统计咨询、数据 管理和信息转移资源，以提高阿尔茨海默病研究的质量 由ADRC核心和附属调查员进行。这将通过实现以下目标来实现： 目标1）为所有Cores的ADRC相关研究提供数据库支持。内核会协调入口 质量控制、管理和分析入组、评价和随访所产生的数据 中心临床核心招募的门诊和对照受试者，以及协调进入，质量 控制、管理和分析中心神经病理学核心和神经影像学产生的数据 临床中心和合作研究者生成的数据。标准入组报告将 每月为亚洲减灾中心的领导层生成一份报告，并将根据需要编写专门报告。芯会 定期与圣地亚哥超级计算机中心沟通，以验证 数据库目标2）为临床和外展、招募和 订婚的核心。核心将根据需要更新数据库功能，支持数据查询， 培训工作人员使用书记官处。目标3）编制ADRC数据库，以便定期提交国家 阿尔茨海默氏症协调中心（NACC），支持新的NACC程序和倡议，并解决NACC 查询。目标4）为ADRC调查人员提供统计设计和分析咨询服务。核心 将为研究建议提供功率计算和统计分析计划，并提供统计 规划和分析积极的研究，开发新的统计方法，需要。目标5） 核心将教育调查人员，学员和初级教师的原则和使用统计分析 方法论。

DATA MANAGEMENT AND STATISTICAL CORE – SUMMARY/ ABSTRACT The Data Management and Statistics Core (the Data Core) provides statistical consulting, data management and information transfer resources to enhance the quality of Alzheimer’s disease research conducted by ADRC Core and affiliate investigators. This will be done by accomplishing the following goals: Aim 1) Provide database support to all Cores’ ADRC related research. The Core will coordinate the entry, quality control, management and analysis of data generated by the enrollment, evaluation, and follow up of outpatient and control subjects recruited by the Center’s Clinical Core, as well as coordinate the entry, quality control, management and analysis of data generated by the Center’s Neuropathology Core, and neuroimaging data generated by the Clinical Core and collaborating investigators. Standard enrollment reports will be generated monthly for ADRC leadership, specialized reports will be prepared as needed. The Core will communicate with San Diego Super Computer Center regularly to verify the security and integrity of the database. Aim 2) Provide and support a Registry database for the Clinical and the Outreach, Recruitment, and Engagement Cores. The Core will update the database functionality as needed, support data queries, and train staff in the use of the Registry. Aim 3) Prepare the ADRC database for routine submission to the National Alzheimer’s Coordinating Center (NACC), support new NACC procedures and initiatives, and resolve NACC queries. Aim 4) Provide statistical design and analysis consultation services to ADRC investigators. The Core will provide power calculations and statistical analysis plans for research proposals, and provide statistical programming and analyses for active research, developing novel statistical methods as required. Aim 5) The Core will educate investigators, trainees and junior faculty in the principles and use of statistical analysis methodologies.