Data Management and Statistical Core

数据管理和统计核心--摘要/摘要 数据管理和统计核心(Data Core)提供统计咨询、数据 管理和信息传输资源以提高阿尔茨海默病研究的质量 由ADRC核心和附属调查人员进行。这将通过实现以下目标来实现： 目的1)为各核的ADRC相关研究提供数据库支持。核心将协调进入， 对招生、评估和跟踪所产生的数据进行质量控制、管理和分析 门诊和对照受试者由该中心的临床核心招募，以及协调录入、质量 控制、管理和分析该中心的神经病理核心和神经成像生成的数据 由临床核心和合作研究人员生成的数据。标准注册报告将是 为ADRC领导层每月生成的报告，将根据需要准备专门的报告。核心意志 定期与圣地亚哥超级计算机中心沟通，以验证 数据库。目标2)提供和支持临床和外联、征聘和 接洽核心。核心将根据需要更新数据库功能，支持数据查询，以及 培训工作人员使用登记处。目标3)准备ADRC数据库，以便例行提交给国家 阿尔茨海默氏症协调中心(NACC)，支持新的NACC程序和计划，并解决NACC 查询。目的4)为发改委调查人员提供统计设计和分析咨询服务。《核心》 将为研究提案提供电力计算和统计分析计划，并提供统计 规划和分析积极的研究，根据需要开发新的统计方法。目标5) CORE将对调查人员、受训人员和初级教员进行统计分析的原理和使用方面的教育 方法论。

DATA MANAGEMENT AND STATISTICAL CORE – SUMMARY/ ABSTRACT The Data Management and Statistics Core (the Data Core) provides statistical consulting, data management and information transfer resources to enhance the quality of Alzheimer’s disease research conducted by ADRC Core and affiliate investigators. This will be done by accomplishing the following goals: Aim 1) Provide database support to all Cores’ ADRC related research. The Core will coordinate the entry, quality control, management and analysis of data generated by the enrollment, evaluation, and follow up of outpatient and control subjects recruited by the Center’s Clinical Core, as well as coordinate the entry, quality control, management and analysis of data generated by the Center’s Neuropathology Core, and neuroimaging data generated by the Clinical Core and collaborating investigators. Standard enrollment reports will be generated monthly for ADRC leadership, specialized reports will be prepared as needed. The Core will communicate with San Diego Super Computer Center regularly to verify the security and integrity of the database. Aim 2) Provide and support a Registry database for the Clinical and the Outreach, Recruitment, and Engagement Cores. The Core will update the database functionality as needed, support data queries, and train staff in the use of the Registry. Aim 3) Prepare the ADRC database for routine submission to the National Alzheimer’s Coordinating Center (NACC), support new NACC procedures and initiatives, and resolve NACC queries. Aim 4) Provide statistical design and analysis consultation services to ADRC investigators. The Core will provide power calculations and statistical analysis plans for research proposals, and provide statistical programming and analyses for active research, developing novel statistical methods as required. Aim 5) The Core will educate investigators, trainees and junior faculty in the principles and use of statistical analysis methodologies.