CORE--BIOSTATISTICS AND DATA MANAGEMENT

生物统计和数据库管理核心将为以下方面提供数据库和统计支持： 马约阿尔茨海默病研究中心（ADRC）项目和核心。为此，我们 具体目标是： 具体目标1。开发和维护一个关系数据库， 临床核心收集的临床和神经心理测量数据。 具体目标2。提供数据库支持和生物统计咨询支持， 项目和核心。 在现有的马约ADRC关系数据库结构的基础上， 将扩展临床核心心理测量和临床考试数据库，以适应临床核心引入的新表格和NIA强制要求的新表格（扩展的标准临床数据集）。将对我们的数据库进行各种改进，包括基于网络的数据元素词典和电子数据审计能力。临床核心数据库将与影像学、基因型、神经病理学、DNA和血浆库存数据库链接，数据管理人员将支持核心和项目研究者的数据请求。生物统计学家将在研究设计、分析和解释方面为核心和项目研究者提供支持。生物统计和数据库管理核心将为所有核心和项目提供数据库支持和专门的统计咨询时间。数据库和统计人员的共享将使我们能够有效地支持各种项目，并确保核心和项目可以使用熟悉阿尔茨海默病和马约诊所ADRC详细信息的生物统计顾问。

The Biostatistics and Database Management Core will provide database and statistical support to the Mayo Alzheimer's Disease Research Center (ADRC) Projects and Cores. To this end, our specific aims are: Specific Aim 1. To develop and maintain a relational database housing the longitudinal clinical and neuropsychometric data gathered by the Clinical Core. Specific Aim 2. To provide database support and biostatistical consulting support to the Projects and Cores. Building upon the existing Mayo ADRC relational database structure, database management staff will expand the Clinical Core psychometric and clinical exam database to accommodate new forms introduced by the Clinical Core and new forms mandated by the NIA (the expanded standard clinical data set). Various improvements to our database will be implemented, including a web-based data element dictionary and electronic data audit capabilities. The Clinical Core database will be linked to imaging, genotype, neuropathology, and DNA and plasma inventory databases, and data management staff will support data requests by Core and Project investigators. Biostatisticians will support Core and Project investigators in study design, analysis, and interpretation. The Biostatistics and Database Management Core will provide database support and dedicated time for statistical consulting to all of the Cores and Projects. Sharing of database and statistical personnel will allow us to efficiently support various projects and ensure that biostatistical consultants familiar with Alzheimer's disease and with the details of the Mayo Clinic ADRC are available to Cores and Projects.