Neuropathology Core

神经病理学核心

• 批准号: 10407982
• 负责人: Robert A Rissman
• 金额: $ 29.22万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10407982
• 关键词: Alzheimer' s Disease; Alzheimer' s disease pathology; Animal Model; Autopsy; Biochemistry; Blood Vessels; Brain; C9ORF72; Cells; Cessation of life; Clinical; Collaborations; Collection; Data; Dementia; Dementia with Lewy Bodies; Diagnosis; Diagnostic; Disease; Documentation; Education; Enrollment; Equipment and supply inventories; Evaluation; Eye; Faculty; Fostering; Frontotemporal Dementia; Funding; Gene Expression; Genetic Diseases; Genetic Transcription; Genetic Variation; Guidelines; Immunohistochemistry; Informatics; International; Lewy Body Disease; Mentors; Methods; Microscopy; Mission; Nerve Degeneration; Neurodegenerative Disorders; Neurons; Paper; Participant; Pathogenesis; Pathologic; Pathology; Patients; Philanthropic Fund; Procedures; Process; Proteins; Protocols documentation; Publishing; Research; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Role; Sampling; Scanning; Scientist; Series; Skin; Slide; Specimen; Spinal Cord; Standardization; Students; Supervision; Synapses; System; Tauopathies; Techniques; Time; Tissue Banks; Tissue Sample; Tissues; age related; aged; alpha synuclein; biobank; brain tissue; clinical diagnosis; data management; data resource; demented; exosome; frontotemporal lobar dementia-amyotrophic lateral sclerosis; genome-wide analysis; graduate student; induced pluripotent stem cell; interest; investigator training; meetings; minority children; minority investigator; minority scientist; neuropathology; next generation; novel; outreach; protein TDP-43; ranpirnase; recruit; repository; symposium; synucleinopathy; tau Proteins; transcriptomics; undergraduate student; working group

NEUROPATHOLOGY CORE - SUMMARY/ ABSTRACT For the past 35 years, the UCSD-ADRC Neuropathology Core has been instrumental in providing support for establishing the accuracy of clinical diagnosis of Alzheimer's Disease (AD) and dementia with Lewy bodies (DLB), delineating structural and clinico-pathological correlates of dementia in AD, identifying new neuropathological entities causing dementia, providing tissues to investigators and helping to better understand the mechanisms of synaptic and other aspects of neurodegeneration in AD. For the renewal there will be 6 Aims of the Neuropathology Core: 1) perform rapid autopsies and procure brains from the ADRC participants, using a standardized protocol; 2) perform standardized neuropathological diagnoses and immunocytochemical analysis of demented and normal aged (control) patients clinically evaluated by the UCSD ADRC following the new NIA criteria; 3) perform clinical neuropathology assessments on brain, spinal cords and eyes from postmortem material from ADRC participants using best practice (NIA-AA) guidelines. Perform immunochemical analysis relevant to neurodegeneration and synapse loss in MCI and early AD cases; 4) maintain a state of the art brain repository to provide the ADRC projects and other investigators with well characterized including early AD and MCI cases; 5) foster the utilization of the ADRC Neuropathology tissue repository for new research and inter-center collaborations. Approximately 50 to 60 cases and over 100 tissue requests are processed a year. The neuropathological results will be submitted to the National Alzheimer’s Coordinating Committee (NACC) in compliance with NIA requirements. As part of the mission of the Core we will also continue to support extensive collaborations with national and international investigators and train fellows, residents, graduate and undergraduate students in neuropathology and microscopy techniques. With the ADRC Outreach, Recruitment and Education (ORE) Core organize meetings to encourage the use of the neuropathology core; 6) Mentor young and minority investigators in neuropathology and neuropathological research. We will foster the next generation of scientists by encouraging them to conduct research with the postmortem tissues. We will continue to provide tissues to local and national investigators and for multi-center initiatives such as the Genome-Wide Analysis Studies organized by NIA.

神经病理学核心-摘要/摘要 在过去的35年里，UCSD-ADRC神经病理学核心在提供支持方面发挥了重要作用 为确定阿尔茨海默病(AD)和路易体痴呆临床诊断的准确性 (DLB)，描述AD痴呆的结构和临床病理相关性，确定新的 导致痴呆症的神经病理实体，为调查人员提供组织并帮助更好地 了解阿尔茨海默病中突触和神经退行性变的其他方面的机制。为了在那里的更新 将是神经病理学核心的6个目标：1)进行快速尸检并从ADRC获取大脑 参与者，使用标准化方案；2)执行标准化的神经病理诊断和 痴呆患者和正常老年人(对照组)的免疫细胞化学分析 UCSD ADRC遵循新的NIA标准；3)对脑、脊髓进行临床神经病理学评估 使用最佳实践(NIA-AA)指南从ADRC参与者的尸检材料中提取眼线和眼线。 对MCI和早期AD患者进行与神经元变性和突触丢失相关的免疫化学分析 案例；4)维护最先进的脑库，为ADRC项目和其他调查人员提供 特征明确，包括早期AD和MCI病例；5)促进ADRC神经病理学的应用 用于新研究和中心间协作的组织信息库。大约50至60例，100多例 纸巾申请每年处理一次。神经病理结果将提交给国家 阿尔茨海默氏症协调委员会(NACC)遵守NIA的要求。作为使命的一部分 我们还将继续支持与国家和国际调查人员的广泛合作 并培训研究员、住院医生、研究生和本科生学习神经病理学和显微镜 技巧。与ADRC外联、招募和教育(ORE)核心组织会议，以 鼓励使用神经病理学核心；6)指导年轻的和少数族裔的神经病理学研究人员 和神经病理学研究。我们将通过鼓励下一代科学家 对身体组织进行研究。我们将继续为地方和国家提供纸巾 研究人员和多中心倡议，如由NIA组织的全基因组分析研究。