Neuropathology Core

神经病理学核心-总结/摘要 在过去的35年里，UCSD-ADRC神经病理学核心一直在提供支持 用于建立阿尔茨海默病（AD）和路易体痴呆的临床诊断的准确性 (DLB)，描绘AD痴呆的结构和临床病理学相关性， 神经病理实体导致痴呆症，为研究人员提供组织，并帮助更好地 了解AD中神经退行性变的突触和其他方面的机制。为了那里的重建 将是神经病理学核心的6个目标：1）进行快速尸检，并从ADRC获取大脑 参与者，使用标准化的协议; 2）进行标准化的神经病理学诊断， 痴呆和正常老年患者（对照）的免疫细胞化学分析， UCSD ADRC遵循新的NIA标准; 3）对脑、脊髓和神经系统进行临床神经病理学评估 使用最佳实践（NIA-AA）指南，从ADRC参与者的尸检材料中提取的声带和眼睛。 进行与MCI和早期AD的神经变性和突触丢失相关的免疫化学分析 病例; 4）保持最先进的大脑储存库，为ADRC项目和其他调查人员提供 包括早期AD和MCI病例; 5）促进ADRC神经病理学的利用 新研究和中心间合作的组织库。大约有50到60个病例， 组织申请一年处理一次。神经病理学结果将提交给国家 阿尔茨海默氏症协调委员会（NACC）符合NIA的要求。作为联合国使命的一部分， 我们还将继续支持与国家和国际调查人员的广泛合作 并培训研究员、住院医生、研究生和本科生神经病理学和显微镜检查 技术.与ADRC外联，招聘和教育（ORE）核心组织会议， 鼓励使用神经病理学核心; 6）指导年轻和少数民族神经病理学研究人员 和神经病理学研究。我们将通过鼓励下一代科学家 用死后的组织进行研究我们将继续为当地和国家提供组织 研究人员和多中心的倡议，如全基因组分析研究由NIA组织。

NEUROPATHOLOGY CORE - SUMMARY/ ABSTRACT For the past 35 years, the UCSD-ADRC Neuropathology Core has been instrumental in providing support for establishing the accuracy of clinical diagnosis of Alzheimer's Disease (AD) and dementia with Lewy bodies (DLB), delineating structural and clinico-pathological correlates of dementia in AD, identifying new neuropathological entities causing dementia, providing tissues to investigators and helping to better understand the mechanisms of synaptic and other aspects of neurodegeneration in AD. For the renewal there will be 6 Aims of the Neuropathology Core: 1) perform rapid autopsies and procure brains from the ADRC participants, using a standardized protocol; 2) perform standardized neuropathological diagnoses and immunocytochemical analysis of demented and normal aged (control) patients clinically evaluated by the UCSD ADRC following the new NIA criteria; 3) perform clinical neuropathology assessments on brain, spinal cords and eyes from postmortem material from ADRC participants using best practice (NIA-AA) guidelines. Perform immunochemical analysis relevant to neurodegeneration and synapse loss in MCI and early AD cases; 4) maintain a state of the art brain repository to provide the ADRC projects and other investigators with well characterized including early AD and MCI cases; 5) foster the utilization of the ADRC Neuropathology tissue repository for new research and inter-center collaborations. Approximately 50 to 60 cases and over 100 tissue requests are processed a year. The neuropathological results will be submitted to the National Alzheimer’s Coordinating Committee (NACC) in compliance with NIA requirements. As part of the mission of the Core we will also continue to support extensive collaborations with national and international investigators and train fellows, residents, graduate and undergraduate students in neuropathology and microscopy techniques. With the ADRC Outreach, Recruitment and Education (ORE) Core organize meetings to encourage the use of the neuropathology core; 6) Mentor young and minority investigators in neuropathology and neuropathological research. We will foster the next generation of scientists by encouraging them to conduct research with the postmortem tissues. We will continue to provide tissues to local and national investigators and for multi-center initiatives such as the Genome-Wide Analysis Studies organized by NIA.