Neuropathology Core
Neuropathology Core
批准号:
10407982
负责人:
Robert A Rissman
金额:
$29.22万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-05-01 至 2024-03-31
关键词:
Alzheimer&aposs DiseaseAlzheimer&aposs disease pathologyAnimal ModelAutopsyBiochemistryBlood VesselsBrainC9ORF72CellsCessation of lifeClinicalCollaborationsCollectionDataDementiaDementia with Lewy BodiesDiagnosisDiagnosticDiseaseDocumentationEducationEnrollmentEquipment and supply inventoriesEvaluationEyeFacultyFosteringFrontotemporal DementiaFundingGene ExpressionGenetic DiseasesGenetic TranscriptionGenetic VariationGuidelinesImmunohistochemistryInformaticsInternationalLewy Body DiseaseMentorsMethodsMicroscopyMissionNerve DegenerationNeurodegenerative DisordersNeuronsPaperParticipantPathogenesisPathologicPathologyPatientsPhilanthropic FundProceduresProcessProteinsProtocols documentationPublishingResearchResearch PersonnelResearch Project GrantsResearch SupportResource SharingResourcesRoleSamplingScanningScientistSeriesSkinSlideSpecimenSpinal CordStandardizationStudentsSupervisionSynapsesSystemTauopathiesTechniquesTimeTissue BanksTissue SampleTissuesage relatedagedalpha synucleinbiobankbrain tissueclinical diagnosisdata managementdata resourcedementedexosomefrontotemporal lobar dementia-amyotrophic lateral sclerosisgenome-wide analysisgraduate studentinduced pluripotent stem cellinterestinvestigator trainingmeetingsminority childrenminority investigatorminority scientistneuropathologynext generationnoveloutreachprotein TDP-43ranpirnaserecruitrepositorysymposiumsynucleinopathytau Proteinstranscriptomicsundergraduate studentworking group
中文摘要
神经病理学核心-摘要/摘要
在过去的35年里,UCSD-ADRC神经病理学核心在提供支持方面发挥了重要作用
为确定阿尔茨海默病(AD)和路易体痴呆临床诊断的准确性
(DLB),描述AD痴呆的结构和临床病理相关性,确定新的
导致痴呆症的神经病理实体,为调查人员提供组织并帮助更好地
了解阿尔茨海默病中突触和神经退行性变的其他方面的机制。为了在那里的更新
将是神经病理学核心的6个目标:1)进行快速尸检并从ADRC获取大脑
参与者,使用标准化方案;2)执行标准化的神经病理诊断和
痴呆患者和正常老年人(对照组)的免疫细胞化学分析
UCSD ADRC遵循新的NIA标准;3)对脑、脊髓进行临床神经病理学评估
使用最佳实践(NIA-AA)指南从ADRC参与者的尸检材料中提取眼线和眼线。
对MCI和早期AD患者进行与神经元变性和突触丢失相关的免疫化学分析
案例;4)维护最先进的脑库,为ADRC项目和其他调查人员提供
特征明确,包括早期AD和MCI病例;5)促进ADRC神经病理学的应用
用于新研究和中心间协作的组织信息库。大约50至60例,100多例
纸巾申请每年处理一次。神经病理结果将提交给国家
阿尔茨海默氏症协调委员会(NACC)遵守NIA的要求。作为使命的一部分
我们还将继续支持与国家和国际调查人员的广泛合作
并培训研究员、住院医生、研究生和本科生学习神经病理学和显微镜
技巧。与ADRC外联、招募和教育(ORE)核心组织会议,以
鼓励使用神经病理学核心;6)指导年轻的和少数族裔的神经病理学研究人员
和神经病理学研究。我们将通过鼓励下一代科学家
对身体组织进行研究。我们将继续为地方和国家提供纸巾
研究人员和多中心倡议,如由NIA组织的全基因组分析研究。
英文摘要
NEUROPATHOLOGY CORE - SUMMARY/ ABSTRACT
For the past 35 years, the UCSD-ADRC Neuropathology Core has been instrumental in providing support
for establishing the accuracy of clinical diagnosis of Alzheimer's Disease (AD) and dementia with Lewy bodies
(DLB), delineating structural and clinico-pathological correlates of dementia in AD, identifying new
neuropathological entities causing dementia, providing tissues to investigators and helping to better
understand the mechanisms of synaptic and other aspects of neurodegeneration in AD. For the renewal there
will be 6 Aims of the Neuropathology Core: 1) perform rapid autopsies and procure brains from the ADRC
participants, using a standardized protocol; 2) perform standardized neuropathological diagnoses and
immunocytochemical analysis of demented and normal aged (control) patients clinically evaluated by the
UCSD ADRC following the new NIA criteria; 3) perform clinical neuropathology assessments on brain, spinal
cords and eyes from postmortem material from ADRC participants using best practice (NIA-AA) guidelines.
Perform immunochemical analysis relevant to neurodegeneration and synapse loss in MCI and early AD
cases; 4) maintain a state of the art brain repository to provide the ADRC projects and other investigators with
well characterized including early AD and MCI cases; 5) foster the utilization of the ADRC Neuropathology
tissue repository for new research and inter-center collaborations. Approximately 50 to 60 cases and over 100
tissue requests are processed a year. The neuropathological results will be submitted to the National
Alzheimer’s Coordinating Committee (NACC) in compliance with NIA requirements. As part of the mission of
the Core we will also continue to support extensive collaborations with national and international investigators
and train fellows, residents, graduate and undergraduate students in neuropathology and microscopy
techniques. With the ADRC Outreach, Recruitment and Education (ORE) Core organize meetings to
encourage the use of the neuropathology core; 6) Mentor young and minority investigators in neuropathology
and neuropathological research. We will foster the next generation of scientists by encouraging them to
conduct research with the postmortem tissues. We will continue to provide tissues to local and national
investigators and for multi-center initiatives such as the Genome-Wide Analysis Studies organized by NIA.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
HABS-HD - Core D - Omics Core
-
批准号:10493848
-
项目类别:
-
资助金额:$918.05万
-
财政年份:2022
-
负责人:Robert A Rissman
-
依托单位:
Novel Systemic Delivery of Peptide-Mediated Anti-Sense Oligonucleotides for Dementia with Lewy Bodies
-
批准号:10186335
-
项目类别:
-
资助金额:$175.11万
-
财政年份:2021
-
负责人:Robert A Rissman
-
依托单位:
Novel Antagonists of the N-terminal Domain of the CRF Receptor Type 1 for Alzheimer's Disease
-
批准号:10433769
-
项目类别:
-
资助金额:$35.45万
-
财政年份:2020
-
负责人:Robert A Rissman
-
依托单位:
Biomarker Core
-
批准号:10615171
-
项目类别:
-
资助金额:$23.22万
-
财政年份:2019
-
负责人:Robert A Rissman
-
依托单位:
Neuropathology Core
-
批准号:10615167
-
项目类别:
-
资助金额:$31.24万
-
财政年份:2019
-
负责人:Robert A Rissman
-
依托单位:
Biomarker Core
-
批准号:10407984
-
项目类别:
-
资助金额:$21.82万
-
财政年份:2019
-
负责人:Robert A Rissman
-
依托单位:
Proteomic characterization of exosomes from AD patients
-
批准号:9563205
-
项目类别:
-
资助金额:$84.4万
-
财政年份:2017
-
负责人:Robert A Rissman
-
依托单位:
Pathogenicity of neuronally-derived tau in exosomes
-
批准号:9336219
-
项目类别:
-
资助金额:$19.38万
-
财政年份:2016
-
负责人:Robert A Rissman
-
依托单位:
Validation Studies of CRF Receptor 1 as a Target for AD
-
批准号:9325287
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2016
-
负责人:Robert A Rissman
-
依托单位:
Polytherapy for AD: Combining Gamma-secretase Modulation and CRFR1 Antagonism
-
批准号:8771201
-
项目类别:
-
资助金额:$19.38万
-
财政年份:2014
-
负责人:Robert A Rissman
-
依托单位:
Polytherapy for AD: Combining Gamma-secretase Modulation and CRFR1 Antagonism
-
批准号:8917840
-
项目类别:
-
资助金额:$22.55万
-
财政年份:2014
-
负责人:Robert A Rissman
-
依托单位:
Stress and CRF Signaling in Alzheimer?s Disease Pathogenesis
-
批准号:7898638
-
项目类别:
-
资助金额:$37.84万
-
财政年份:2008
-
负责人:Robert A Rissman
-
依托单位:
Stress and CRF Signaling in Alzheimer?s Disease Pathogenesis
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批准号:7508580
-
项目类别:
-
资助金额:$39.11万
-
财政年份:2008
-
负责人:Robert A Rissman
-
依托单位:
Stress and CRF Signaling in Alzheimer?s Disease Pathogenesis
-
批准号:7673344
-
项目类别:
-
资助金额:$40.09万
-
财政年份:2008
-
负责人:Robert A Rissman
-
依托单位:
Stress and CRF Signaling in Alzheimer?s Disease Pathogenesis
-
批准号:8105068
-
项目类别:
-
资助金额:$36.37万
-
财政年份:2008
-
负责人:Robert A Rissman
-
依托单位:
Stress and CRF Signaling in Alzheimer?s Disease Pathogenesis
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批准号:8309237
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项目类别:
-
资助金额:$36.37万
-
财政年份:2008
-
负责人:Robert A Rissman
-
依托单位:
Role of Intracellular ABeta in Tau Pathology
-
批准号:6738775
-
项目类别:
-
资助金额:$4.16万
-
财政年份:2004
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负责人:Robert A Rissman
-
依托单位:
a-Synuclein vulnerability mechanisms and therapeutics in Alzheimer's Disease
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批准号:10360204
-
项目类别:
-
资助金额:$39.5万
-
财政年份:2001
-
负责人:Robert A Rissman
-
依托单位:
a-Synuclein vulnerability mechanisms and therapeutics in Alzheimer's Disease
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批准号:10232069
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项目类别:
-
资助金额:$50.63万
-
财政年份:2001
-
负责人:Robert A Rissman
-
依托单位:
BIOMARKER CORE
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批准号:8601648
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项目类别:
-
资助金额:$21.7万
-
财政年份:--
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负责人:Robert A Rissman
-
依托单位:
国内基金
海外基金
新型F-18标记香豆素衍生物PET探针的研制及靶向Alzheimer's Disease 斑块显像研究
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批准号:81000622
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项目类别:青年科学基金项目
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资助金额:20.0万元
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批准年份:2010
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负责人:梁胜
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依托单位:
阿尔茨海默病(Alzheimer's disease,AD)动物模型构建的分子机理研究
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批准号:31060293
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项目类别:地区科学基金项目
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资助金额:26.0万元
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批准年份:2010
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负责人:郭亚芬
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依托单位:
跨膜转运蛋白21(TMP21)对引起阿尔茨海默病(Alzheimer'S Disease)的γ分泌酶的作用研究
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批准号:30960334
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项目类别:地区科学基金项目
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资助金额:22.0万元
-
批准年份:2009
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负责人:董贵成
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依托单位: