Biomarker Core

生物标志物核心摘要/摘要 在此次续签申请中，我们将在加州大学圣迭戈分校ADRC的现有基础设施中增加一个BiomMarkers核心。 自1984年成立以来，UCSD ADRC一直致力于开发一系列强大的生物流体和 来自队列的神经图像已经被整合到神经病理学和临床核心中， 分别进行了分析。随着我们项目和研究的需要以及本RFA的指导，我们正在 建立一个专门的生物标志物核心来管理、分析和共享ADRC生物流体和图像及其 相关数据集。 我们预计，我们的流体和成像资源将极大地帮助识别潜在的新机制 痴呆症。我们提出了Biomarkers核心的五个目标：1)使用已建立的生物流体和图像采集 标准操作规程和最佳实践指南；2)对脑脊液和成像进行标准化生物标记物分析； 包括Aβ和tau水平，apoE和trem2基因分型，海马区，皮质和脑室体积和 分析β和tau PET扫描；3)开发最先进的生物库和成像数据集，以支持 国内和国际研究；4)开发和维护最先进的生物流体和成像 为ADRC项目和其他调查人员提供具有良好特点的存储库，包括早期AD和 MCI病例；5)促进ADRC生物流体和图像的利用，用于新的研究和中心间 合作。 与ADRC外联、招募和教育(ORE)核心组织会议，鼓励使用 生物标志物的核心。我们将继续为当地和国家调查人员以及多中心提供DNA 诸如NCRAD和由NIA组织的全基因组分析研究等倡议。

BIOMARKER CORE SUMMARY/ ABSTRACT In this renewal application, we will add a Biomarkers Core to the existing infrastructure of the UCSD ADRC. Since its inception in 1984, the UCSD ADRC has committed to developing a robust collection of biofluids and neuroimages from the cohort which have been integrated into the Neuropathology and Clinical Cores, respectively. With the needs of our program and research increasing and the instructions of this RFA, we are establishing a dedicated Biomarkers Core to manage, analyze and share ADRC biofluids and images and their related datasets. We anticipate that our fluid and imaging resources will greatly aid in identifying new mechanisms underlying dementia. We propose 5 Aims of the Biomarkers Core: 1) Biofluid and image collection using established SOPs and best practice guidelines; 2) Perform standardized biomarker analyses on CSF and imaging, including Aβ and tau levels, APOE and TREM2 genotyping, hippocampal, cortical and ventricular volumes and analysis of Aβ and tau PET scans; 3) Develop a state of the art biobank and imaging dataset to support research nationally and internationally; 4) Develop and maintain a state of the art biofluid and imaging repository to provide the ADRC projects and other investigators with well characterized including early AD and MCI cases; 5) Foster the utilization of the ADRC Biofluids and images for new research and inter-center collaborations. With the ADRC Outreach, Recruitment and Education (ORE) Core organize meetings to encourage the use of the biomarkers core. We will continue to provide DNA to local and national investigators and for multi-center initiatives such as NCRAD and the Genome-Wide Analysis Studies organized by NIA.