权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

BRAINSTORM - Wireless deep BRAIN STimulation thrOugh engineeRed Multifunctinal nanomaterials

BRAINSTORM - 通过工程多功能纳米材料进行无线深度脑刺激

基本信息

批准号：
10067458
负责人：
金额：
$ 52.16万
依托单位：
UNIVERSITY OF GLASGOW
依托单位国家：
英国
项目类别：
EU-Funded
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=10067458
关键词：
BRAINSTORM Wireless deep BRAIN STimulation

项目摘要

BRAINSTORM will introduce an innovative, scalable, wireless, multimodal nanoinvasive neuromodulation technology suitable for independent and switchable excitation and inhibition of deep brain neurons. BRAINSTORM breakthrough relies on novel smart anisotropic magnetic nanomaterials (SMNs) acting both as nanoscale ‘heaters’ and as ‘torquers’ by leveraging either hysteretic losses under kHz frequencies or transitions from vortex to in-plane magnetization under Hz frequencies. Intrinsic bimodal functionality that permits direct control of thermosensitive or mechanosenitive neurons, will be boosted by advanced polymer functionalization to transfer torques to electrical signals trough piezoelectric coating, and to enable transport and delivery of viral vectors to targeted neurons for genetic targeting with sensory channels. SMNs will also be steered to endogenoussensory channelsrelying on antibody targeting. Selected actuation of ion channels that respond to thermal or mechanical stimulus will permit selective activation or inhibition of targeted neuronal populations identifiable by magnetic resonance imaging. Advanced driving electronics will include to metamaterial solenoid coils for rapid frequency switch for control of ‘mechanical’ or ‘thermal’ functionality while focused ultrasound will facilitate non invasive delivery of SMNs in the targeted brain area. The ability of the BRAINSTORM platform to shape behaviour and demonstrate therapeutic potential by modulating the excitation/inhibition balance through thermal/mechanical/electrical modalities will be demonstrated in mouse models of Fragile X syndrome.

BRADIORM将推出一种创新的、可扩展的、无线的、多模式的纳米侵入性神经调节技术，适用于独立和可切换的大脑深部神经元的兴奋和抑制。BRADIORM的突破依赖于新型智能各向异性磁性纳米材料（SMN），通过利用kHz频率下的滞后损耗或Hz频率下从涡旋到面内磁化的转变，既可作为纳米级“加热器”，又可作为“扭矩器”。允许直接控制热敏性或机械敏感性神经元的固有双峰功能性将通过先进的聚合物官能化来增强，以通过压电涂层将扭矩传递到电信号，并使病毒载体能够运输和递送到靶向神经元，用于与感觉通道的遗传靶向。SMNs也将被引导到依赖于抗体靶向的内源性感觉通道。响应于热或机械刺激的离子通道的选择性致动将允许通过磁共振成像可识别的靶向神经元群体的选择性激活或抑制。先进的驱动电子设备将包括超材料螺线管线圈，用于快速频率切换，以控制“机械”或“热”功能，而聚焦超声将有助于在目标大脑区域无创输送SMN。将在脆性X综合征小鼠模型中证明BRADIORM平台通过热/机械/电模式调节兴奋/抑制平衡来塑造行为并展示治疗潜力的能力。