Core C Imaging

成像核心-核心C：项目总结/摘要 BIOCARD研究是对349名认知正常的个体进行的纵向观察性研究， 入组时主要为中年（平均年龄=57.1岁）。这些受试者现在已经被随访了27年。 该项目的总体目标是进一步推进临床前阿尔茨海默病的研究 通过：（1）阐明AD生物标志物（包括基于CSF，血液，MRI， 和PET成像）和认知;待研究的生物标志物包括几种有前途的新型生物标志物 血液脑脊液和脑成像的结果(2)最大化我们的数据，通过与多个 拥有可比数据的研究小组，以及（3）提供可公开访问的数据，大脑扫描，以及 生物标本，供该领域的研究人员使用。为了实现这些目标，我们建立了7个核心， 本申请还包括2个项目。成像核心（Core C）负责监督 磁共振成像（MRI）扫描和正电子发射的采集和分析 BIOCARD研究参与者的断层扫描（PET）。具体目标包括：（1）促进 在参与者中持续采集3 T MRI扫描，（2）促进持续纵向采集 使用匹兹堡化合物B（PiB）进行PET扫描，并使用MK 6240启动Tau PET成像，（3） 将在NIH收集的1.5T体积数据与在Johns收集的3 T MRI体积数据整合 霍普金斯，（4）将MRI和PET成像数据与临床、认知、CSF和血液生物标志物整合 由核心B和D以及项目1生成的数据，（5）用于检查MRI和PET的顺序和时间 临床前阿尔茨海默病期间生物标志物的变化，（6）整合脑组织的高场MRI图像 在相同的个体中具有详细的神经病理学发现，以及（7）继续共享图像文件， 与该领域的研究者进行相关的临床信息交流。

IMAGING CORE – CORE C: PROJECT SUMMARY/ABSTRACT The BIOCARD study is a longitudinal, observational study of 349 individuals who were cognitively normal and primarily middle aged (mean age=57.1) at enrollment. The subjects have now been followed for up to 27 years. The overall objectives of the project are to further advance the study of preclinical Alzheimer’s disease by: (1) clarifying the pattern and rate of change in AD biomarkers (including those based on CSF, blood, MRI, and PET imaging) and cognition; the biomarkers to be studied include several promising novel biomarkers derived from blood, CSF and brain imaging. (2) maximizing our data by working collaboratively with several research groups who have comparable data, and (3) providing a publicly accessible data, brain scans, and biological specimens, for researchers in the field. To accomplish these goals we established 7 Cores and, with this application, are also including 2 projects. The Imaging Core (Core C) is responsible for overseeing the acquisition and analysis of magnetic resonance imaging (MRI) scans and positron emission tomography (PET) scans in the BIOCARD study participants. The specific aims include: (1) to facilitate the continued acquisition of 3T MRI scans in the participants, (2) to facilitate the continued longitudinal acquisition of PET scans, using Pittsburgh Compound B (PiB), and the initiation of Tau PET imaging, using MK6240, (3) to integrate the 1.5T volumetric data collected at the NIH with the 3T MRI volumetric data collected at Johns Hopkins, (4) to integrate the MRI and PET imaging data with the clinical, cognitive, CSF and blood biomarker data generated by Cores B and D and Project 1, (5) to examine the order and timing of MRI and PET biomarker changes during preclinical Alzheimer’s disease, (6) to integrate high field MRI images of brain tissue with detailed neuropathological findings in the same individuals, and (7) to continue to share image files and related clinical information with investigators in the field.