Impact of Early-life Exposure to Semi-Volatile Organic Compounds (SVOCs) on Neonatal and Early Childhood Immune Function

生命早期接触半挥发性有机化合物 (SVOC) 对新生儿和幼儿免疫功能的影响

• 批准号: 10410116
• 负责人: Jennifer K Hoffman
• 金额: $ 71.61万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-21 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410116
• 关键词: Active immunity; Affect; Age-Months; Allergic; Animals; Antibodies; Antibody Formation; Antibody Response; Antigens; Autoimmune Diseases; Binding; Birth; Blood specimen; Cellular Immunity; Characteristics; Chemicals; Child; Child Health; Childhood; Cohort Studies; Collection; Communicable Diseases; Data; Developed Countries; Development; Diphtheria; Disease; Electronics; Environmental Exposure; Environmental Impact; Environmental Pollution; Environmental Risk Factor; Esters; Exposure to; Fetus; Flame Retardants; Frequencies; Furniture; General Population; Goals; Health; Human; IgG Receptors; Immune; Immune response; Immune system; Immunity; Immunoglobulin G; Impairment; In Vitro; Incidence; Individual; Indoor environment; Infant; Infection; Infrastructure; Intervention; Life; Maternal antibody; Measurement; Measures; Medical; Modeling; Monitor; Morbidity - disease rate; Mus; Neonatal; Organophosphates; Outcome; Passive Transfer of Immunity; Pertussis Vaccine; Pesticides; Placenta; Plasticizers; Play; Policies; Population; Population Policies; Predisposition; Pregnancy; Pregnancy Trimesters; Property; Prospective cohort; Public Health; Reporting; Research; Resources; Role; Silicones; Specimen; Systems Development; Testing; Tetanus; Umbilical Cord Blood; Vaccination; Vaccines; Woman; base; building materials; cell mediated immune response; cohort; design; early childhood; early life exposure; emerging pathogen; environmental chemical; epidemiology study; experience; exposed human population; follow-up; immune function; immune health; immune system function; immunoregulation; improved; infancy; infant death; infant morbidity/mortality; influenza virus vaccine; mortality; multiplex assay; neoantigens; neonate; neutralizing antibody; novel; pathogen; personal care products; phthalates; prevent; prospective; response; seasonal influenza; vaccine response; volatile organic compound

Project Summary The immune system plays a critical role in maintaining a child’s health, and immune deficits may have serious consequences ranging from increased susceptibility to infections to allergic and autoimmune conditions. Although many factors contribute to overall immune health, emerging data suggest that early life environmental exposures interfere with immune development and function. Identifying modifiable environmental factors that affect children’s immunity, our overarching goal is critical to reducing infant morbidity and mortality and has long- term implications for improving health. Semi-volatile organic compounds (SVOCs), including organophosphate esters, phthalates, pesticides, and flame retardants, are used in consumer and personal care products, electronics, furniture, and building materials. As a result of their extensive use and environmental persistence, SVOCs are detected with high frequency in indoor environments, and human exposure to mixtures of SVOCs is widespread. Our proposed research assesses exposure to SVOC mixtures throughout pregnancy and in infancy. We will investigate individual characteristics associated with higher levels of exposure and evaluate the potential for adverse health outcomes among exposed women and their children. Animal studies provide compelling evidence that exposure to individual SVOCs impacts immune function; however, the extent to which these studies extend to human populations is unclear, particularly because they largely consider exposure to single chemicals, which does not reflect real-world exposures (i.e., those occurring in mixtures). Our primary objective is to investigate the impacts of early life exposure to SVOC mixtures on children’s immune function, and in doing so, to fill a critical gap in the understanding of the impacts of SVOCs. This study will be the first to evaluate the role of SVOC in altering the protection of the neonate by evaluating the two most critical aspects of early life immune function: 1) passive transfer of immunity and 2) the capacity to respond to a novel pathogen-associated antigen. We will capitalize on the infrastructure of HOPE 1000, an ongoing cohort study with longitudinal collection of SVOC exposure monitors during each trimester of pregnancy and in early childhood, and the biospecimen needed to evaluate immune function and pathogen immunity. Identifying specific SVOCs or mixtures of SVOCs that affect immunity may provide new opportunities for interventions at the individual and policy levels. Such data are critically needed as the use of some SVOCs is predicted to increase in the coming years.

项目总结