Social, environmental, and epigenetic drivers of atopic dermatitis disease course

特应性皮炎病程的社会、环境和表观遗传驱动因素

基本信息

项目摘要

PROJECT SUMMARY/ABSTRACT This is an application for a K23 award for Dr. Katrina Abuabara, a dermatologist, sociologist and epidemiologist at the University of California, San Francisco. Dr. Abuabara is establishing herself as an investigator in the patient-oriented clinical research of atopic dermatitis (eczema). This K23 award will provide Dr. Abuabara with the support necessary to: (1) become an expert at patient-oriented research in atopic dermatitis; (2) combine exposure and risk factor data with genomic and clinical measures; (3) implement advanced methods for longitudinal data analysis; (4) implement bioinformatics for the analysis and presentation of genomic data; and (5) develop an independent clinical research career. To achieve these goals, Dr. Abuabara has assembled a mentoring team comprised of a primary mentor, Dr. Lindsey Criswell, an epigenetic epidemiologist and clinical investigator studying heterogeneous autoimmune disease, and two co-mentors: Dr. Chuck McCulloch, a biostatistician and expert in longitudinal data analysis, and Dr. Pui-Yan Kwok, a dermatologist and human geneticist. Atopic dermatitis affects 10% of the U.S. population across their lifespans from early childhood through elder age, yet varies in severity and disease activity. Some patients have mild disease and others have disease so severe that its impact on quality of life is akin to type 1 diabetes or cystic fibrosis. The disease also waxes and wanes; patients may have periods without active disease that range from days to decades. Research on the variability in the natural history of the disease course is necessary to identify drivers of disease activity and to design personalized intervention strategies. Dr. Abuabara proposes to use electronic medical record and detailed questionnaire data repeated at multiple time points to identify subgroups of individuals with distinct patterns of disease activity (Aim 1), examine which early life exposures, including social and physical environments, are most predictive of disease (Aim 2), and finally test the hypothesis that the effect(s) of these exposures are transmitted via methylation changes to the DNA (Aims 3 and 4). The results will inform future studies examining whether epigenetic changes can be used as predictive biomarkers to identify patients likely to have a more severe course or those who are more likely to respond to treatments.
项目概要/摘要 这是皮肤科医生、社会学家和流行病学家 Katrina Abuabara 博士的 K23 奖项申请 在加州大学旧金山分校。阿布巴拉博士正在将自己定位为该领域的一名调查员 以患者为导向的特应性皮炎(湿疹)临床研究。该 K23 奖项将为阿布巴拉博士提供 必要的支持:(1) 成为以患者为导向的特应性皮炎研究专家; (2) 结合 暴露和风险因素数据以及基因组和临床测量; (三)实施先进方法 纵向数据分析; (4)实施生物信息学来分析和呈现基因组数据;和 (5)发展独立的临床研究事业。为了实现这些目标,阿布巴拉博士组建了一个 指导团队由主要导师 Lindsey Criswell 博士组成,他是一位表观遗传流行病学家和临床 研究异质性自身免疫性疾病的研究者,以及两位共同导师:查克·麦卡洛克 (Chuck McCulloch) 博士,一位 生物统计学家和纵向数据分析专家,以及皮肤科医生和人类学家郭佩恩博士 遗传学家。 特应性皮炎影响着 10% 的美国人,从幼儿期到老年 年龄,但严重程度和疾病活动度各不相同。有些患者病情较轻,有些则病情严重,因此 其对生活质量的影响类似于 1 型糖尿病或囊性纤维化。这种疾病也逐渐加重 衰弱;患者可能会有几天到几十年没有活动性疾病的时期。研究 疾病过程自然史的变异性对于确定疾病活动的驱动因素和 设计个性化干预策略。阿布巴拉博士建议使用电子病历和 在多个时间点重复详细的问卷数据,以确定具有不同特征的个体亚组 疾病活动模式(目标 1),检查哪些早期生活暴露,包括社会和身体暴露 环境最能预测疾病(目标 2),最后检验这些因素的影响的假设 暴露通过 DNA 甲基化变化传播(目标 3 和 4)。结果将为未来提供信息 研究检查表观遗传变化是否可以用作预测生物标志物来识别可能的患者 有更严重的病程或更有可能对治疗产生反应的人。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Patterns of Atopic Eczema Disease Activity From Birth Through Midlife in 2 British Birth Cohorts.
  • DOI:
    10.1001/jamadermatol.2021.2489
  • 发表时间:
    2021-10-01
  • 期刊:
  • 影响因子:
    10.9
  • 作者:
    Abuabara K;Ye M;Margolis DJ;McCulloch CE;Mulick AR;Silverwood RJ;Sullivan A;Williams HC;Langan SM
  • 通讯作者:
    Langan SM
Mixed evidence on the relationship between socioeconomic position and atopic dermatitis: A systematic review.
Association of Atopic Dermatitis and Mental Health Outcomes Across Childhood: A Longitudinal Cohort Study.
  • DOI:
    10.1001/jamadermatol.2021.2657
  • 发表时间:
    2021-10-01
  • 期刊:
  • 影响因子:
    10.9
  • 作者:
    Kern C;Wan J;LeWinn KZ;Ramirez FD;Lee Y;McCulloch CE;Langan SM;Abuabara K
  • 通讯作者:
    Abuabara K
Prenatal and Childhood Tobacco Smoke Exposure Are Associated With Sleep-Disordered Breathing Throughout Early Childhood.
  • DOI:
    10.1016/j.acap.2020.11.003
  • 发表时间:
    2021-05
  • 期刊:
  • 影响因子:
    3.1
  • 作者:
    Ramirez FD;Groner JA;Ramirez JL;McEvoy CT;Owens JA;McCulloch CE;Cabana MD;Abuabara K
  • 通讯作者:
    Abuabara K
Clinical onset of atopic eczema: Results from 2 nationally representative British birth cohorts followed through midlife
  • DOI:
    10.1016/j.jaci.2019.05.040
  • 发表时间:
    2019-09-01
  • 期刊:
  • 影响因子:
    14.2
  • 作者:
    Abuabara, Katrina;Ye, Morgan;Langan, Sinead M.
  • 通讯作者:
    Langan, Sinead M.
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Katrina Elaine Abuabara其他文献

Katrina Elaine Abuabara的其他文献

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{{ truncateString('Katrina Elaine Abuabara', 18)}}的其他基金

Sodium in the Skin and Atopic Dermatitis: The SIS-AD Study
皮肤中的钠与特应性皮炎:SIS-AD 研究
  • 批准号:
    10712714
  • 财政年份:
    2023
  • 资助金额:
    $ 17.44万
  • 项目类别:
Atopic dermatitis in childhood and risk of early cardiovascular disease
儿童特应性皮炎和早期心血管疾病的风险
  • 批准号:
    10382359
  • 财政年份:
    2021
  • 资助金额:
    $ 17.44万
  • 项目类别:
Atopic dermatitis in childhood and risk of early cardiovascular disease
儿童特应性皮炎和早期心血管疾病的风险
  • 批准号:
    10199290
  • 财政年份:
    2021
  • 资助金额:
    $ 17.44万
  • 项目类别:
Social, environmental, and epigenetic drivers of atopic dermatitis disease course
特应性皮炎病程的社会、环境和表观遗传驱动因素
  • 批准号:
    9755364
  • 财政年份:
    2018
  • 资助金额:
    $ 17.44万
  • 项目类别:
Social, environmental, and epigenetic drivers of atopic dermatitis disease course
特应性皮炎病程的社会、环境和表观遗传驱动因素
  • 批准号:
    10188431
  • 财政年份:
    2018
  • 资助金额:
    $ 17.44万
  • 项目类别:

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