Biostatistics and Data Management Core

生物统计和数据管理核心

• 批准号: 10410727
• 负责人: Dana L Tudorascu
• 金额: $ 57.48万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410727
• 关键词: Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Biological Markers; Biometry; Blood; Cerebrovascular Disorders; Clinical; Cognitive; Collaborations; Collection; Data; Data Analyses; Data Element; Data Files; Data Set; Database Management Systems; Databases; Development; Disease Pathway; Disease Progression; Doctor of Philosophy; Ensure; Etiology; Faculty; Future; Goals; Image; Impaired cognition; Individual; Information Systems; Instruction; Lead; Linear Regressions; Machine Learning; Magnetic Resonance Imaging; Methodology; Methods; Mission; Modality; Neurobehavioral Manifestations; Outcome; Outcome Measure; Participant; Pathogenesis; Pathologic; Persons; Play; Population; Positron-Emission Tomography; Postdoctoral Fellow; Preparation; Prevention; Process; Program Research Project Grants; Psychiatry; Publishing; Reporting; Reproducibility; Research; Research Personnel; Research Support; Resources; Rest; Role; Scientist; Series; Source; Statistical Data Interpretation; Statistical Methods; Statistical Models; Students; Testing; Thick; Training; Training and Education; Universities; Work; astrogliosis; base; burden of illness; clinical translation; cohort; computer science; computerized data processing; data integration; data management; data resource; design; distributed data; experience; graduate student; high dimensionality; imaging biomarker; interest; lectures; longitudinal analysis; meetings; mid-career faculty; mild cognitive impairment; neuroimaging; next generation; programs; statistics; theories

BDM Core Summary/Abstract The Biostatistics and Data Management (BDM) Core will be responsible to provide PPG4 projects and investigators with a broad range of statistical and data management expertise. The BDM Core will be responsible for creating, maintaining and seamlessly integrating all collected data (clinical, imaging, biomarkers) in this PPG4, as well as the statistical analysis proposed for each project (correlations, linear regression, path analysis, longitudinal analysis, high- dimensional associations). The BDM core will closely work with the PPG4 Investigators and provide datasets and analysis for each specific hypothesis and will provide investigators with datasets upon request in a format that is easy to use with any statistical analysis program. The BDM Core will work closely with the Imaging Biomarkers Methodology (IBM) Core to facilitate the efficient transfer of raw and processed PET and MR images and imaging outcomes (measures of cortical thickness, regional volumes, and cerebrovascular disease burden) so that the BDM Core can provide data analysis as well as interpretation and dissemination of associations related to imaging outcomes. Similarly, the BDM core will facilitate the integration of the rest of the outcomes (that are not-high-dimensional), cognitive, blood, etc. collected from the other cores to be integrated in the database and used in subsequent analyses. BDM Core will hold weekly Core meetings to discuss data integration in the database, data requests, analysis plans as well as general methodology issues as they arise. The BDM Core will provide training to students, post-doctoral fellows, and faculty in data analysis with focus on analysis methods used in the PPG. In addition, the BDM core will organize monthly seminars with a focus on specific topics with instructional purposes for graduate students and postdocs involved in the PPG4.

BDM核心摘要/摘要 生物统计和数据管理（BDM）核心将负责提供PPG 4 项目和调查人员具有广泛的统计和数据管理专业知识。的 BDM核心将负责创建、维护和无缝集成所有收集到的 本PPG 4中的数据（临床、影像学、生物标志物）以及拟定的统计分析 每个项目（相关性，线性回归，路径分析，纵向分析，高- 维度关联）。BDM核心将与PPG 4研究者密切合作， 为每个特定假设提供数据集和分析，并将为研究者提供 以易于与任何统计分析程序一起使用的格式提供数据集。的 BDM核心将与成像生物标志物方法（IBM）核心密切合作， 有效传输原始和处理后的PET和MR图像以及成像结果 （测量皮质厚度、区域体积和脑血管疾病负担）， BDM核心可以提供数据分析以及解释和传播 与影像学结果相关。同样，BDM核心将促进集成 其余的结果（不是高维的），认知，血液等。 其他核心将被纳入数据库，并用于随后的分析。BDM核心 将每周举行一次核心会议，讨论数据库中的数据集成、数据请求， 分析计划以及出现的一般方法问题。BDM核心将提供 对学生、博士后研究员和教师进行数据分析方面的培训，重点是分析 PPG中使用的方法。此外，BDM核心将组织每月研讨会， 专注于特定的主题，为研究生和博士后提供教学目的 在PPG 4。