New rules and tools to understand and control tissue-tissue collisions.

项目摘要 19世纪生理学家鲁道夫·维肖提出了“细胞状态”的概念，将组织描述为“一种 牢房社会，一个小小的有序的国家，有所有的附属品--高级官员和下属，仆人 和大师，无论是大的还是小的“。今天，这种类比已经证明是恰当的，也证明了我们的大部分理解 细胞在组织内的相互作用植根于社会网络、群体理论和 集体行为。然而，尽管我们对支撑细胞-细胞的生物机制有深入的了解 相互作用，我们对组织本身和社会动力之间的相互作用知之甚少 它们在组织交汇的边界上发挥作用。这样的边界在跨越的过程中至关重要 发展、再生、肿瘤侵袭和伤口愈合，并不仅对 基础生物学，但我们如何控制它将极大地推动生物医学研究。我们的研究目标 这一认识差距来自三个方向：(1)开发研究组织发生什么的新规则 碰撞和愈合；(2)使用这些规则来通知新的工具来组装组织，这些组织如何利用 组织之间的相互作用；以及(3)创造一种可以集成到 通过模仿组织-组织边界上出现的关键相互作用，将组织视为组织的一部分。这个 这项研究的结果不仅将有助于我们对伤口愈合和组织形成的理解，而且还将 提高我们为再生医学和新的生物医学植入材料构建新组织的能力。

Project Abstract The 19th century physiologist Rudolf Virchow presented the concept of the `Cell State', describing tissue as “a society of cells, a tiny well-ordered state, with all of the accessories — high officials and underlings, servants and masters, the great and the small”. Today, this analogy has proven apropos and much of our understanding of the interactions of cells within tissues is rooted in concepts from social networks, swarm theory, and collective behavior. However, despite our deep knowledge of the biological mechanisms underpinning cell-cell interactions, we know quite little about the interactions between tissues themselves and the social dynamics that play out at the boundaries where tissues meet. Such boundaries are crucial in processes spanning development, regeneration, tumor invasion, and wound healing, and a solid understanding not just of the underlying biology but how we might control it would greatly advance biomedical research. Our research targets this gap in knowledge from three directions: (1) developing new rules for studying what happens when tissues collide and heal; (2) using these rules to inform new tools to assemble tissues that take advantage of how tissues interact with each other; and (3) creating a new class of `cell-mimetic' biomaterials can integrate into tissues as if they are part of the tissue by mimicking key interactions that arise at tissue-tissue boundaries. The results of this research will inform not only our understanding of wound healing and tissue formation, but also improve our abilities to build new tissues for regenerative medicine and new biomedical implant materials.