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New rules and tools to understand and control tissue-tissue collisions.

理解和控制组织与组织碰撞的新规则和工具。

基本信息

批准号：
10636834
负责人：
Daniel Cohen
金额：
$ 39.08万
依托单位：
PRINCETON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-15 至 2024-05-31
项目状态：
已结题

项目摘要

Project Abstract The 19th century physiologist Rudolf Virchow presented the concept of the `Cell State', describing tissue as “a society of cells, a tiny well-ordered state, with all of the accessories — high officials and underlings, servants and masters, the great and the small”. Today, this analogy has proven apropos and much of our understanding of the interactions of cells within tissues is rooted in concepts from social networks, swarm theory, and collective behavior. However, despite our deep knowledge of the biological mechanisms underpinning cell-cell interactions, we know quite little about the interactions between tissues themselves and the social dynamics that play out at the boundaries where tissues meet. Such boundaries are crucial in processes spanning development, regeneration, tumor invasion, and wound healing, and a solid understanding not just of the underlying biology but how we might control it would greatly advance biomedical research. Our research targets this gap in knowledge from three directions: (1) developing new rules for studying what happens when tissues collide and heal; (2) using these rules to inform new tools to assemble tissues that take advantage of how tissues interact with each other; and (3) creating a new class of `cell-mimetic' biomaterials can integrate into tissues as if they are part of the tissue by mimicking key interactions that arise at tissue-tissue boundaries. The results of this research will inform not only our understanding of wound healing and tissue formation, but also improve our abilities to build new tissues for regenerative medicine and new biomedical implant materials.

项目摘要 19世纪的生理学家Rudolf Virchow提出了“细胞状态”的概念，将组织描述为“一个一个由细胞组成的社会，一个小而有序的国家，拥有所有的附属品--高级官员和下属，仆人和大师，伟大的和渺小的。今天，这个类比已经被证明是恰当的，细胞在组织内的相互作用是植根于社交网络，群体理论，集体行为然而，尽管我们对细胞间相互作用的生物学机制有着深刻的了解，我们对组织本身和社会动力学之间的相互作用知之甚少，在组织交界处发挥作用。这种界限对于跨越发展，再生，肿瘤侵袭和伤口愈合，以及对肿瘤的认识，但我们如何控制它将大大推进生物医学研究。我们的研究目标这种知识的差距从三个方向：（1）发展新的规则，研究发生了什么，当组织碰撞和愈合;（2）使用这些规则来通知新的工具来组装组织，组织相互作用;（3）创造一类新的“细胞模拟”生物材料，通过模仿在组织-组织边界处出现的关键相互作用，将组织视为组织的一部分。的这项研究的结果不仅将告知我们对伤口愈合和组织形成的理解，提高我们为再生医学和新的生物医学植入材料构建新组织的能力。