权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Mesenchymal Stem Cell Derived A-1 Exosomes for Traumatic Brain Injury

间充质干细胞衍生的 A-1 外泌体治疗创伤性脑损伤

基本信息

批准号：
10411928
负责人：
ASHOK K SHETTY
金额：
$ 56.29万
依托单位：
TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-06-15 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10411928
关键词：
Acute Adverse effects Alzheimer&apos s Disease Animal Model Anti-Inflammatory Agents Behavior Behavioral Biological Assay Brain Caring Cell Therapy Cells Chronic Chronic Disease Chronic Phase Clinical Cognitive Disease Disease model Distress Dose Drug Kinetics Healthcare Systems Inflammation Inflammatory Response Injury Intranasal Administration Intravenous Learning Lipids Location Measures Medical Memory Mesenchymal Mesenchymal Stem Cells Metabolic Molecular Moods Mus Natural Immunity Parkinsonian Disorders Patients Pattern Pharmaceutical Preparations Phase Problem behavior Property Proteomics Protocols documentation Publications RNA Reaction Reagent Reporting Route Safety Short-Term Memory Site Societies Standardization Stress Stromal Cells Swimming Syndrome TBI treatment Testing Therapeutic Index Traumatic Brain Injury Travel Vesicle acquired immunity adult stem cell base behavior test behavioral impairment cytokine depressive symptoms effective therapy exosome feeding improved mouse model neuroinflammation novel novel therapeutics object recognition prevent stem water maze

项目摘要

Project Summary/Abstract “Mesenchymal Stem Cell Derived A1-Exosomes for Traumatic Brain Injury” This proposal will develop a novel therapy for severe traumatic brain injury (TBI), a condition that has devastating effects on the victims and creates a large burden over $55 billion per year on the US healthcare system. One of the distressing features of TBI is that after the acute phase, the patients gradually develop behavioral deficits. As a result, the disease is now considered as a chronic syndrome that involves a viscous cycle in which the initial inflammatory response is excessive so that it causes considerable injury to the brain and thereby triggers another round of lasting inflammation. Numerous anti-inflammatory agents have been tested for treating TBI, but none have yet been accepted as part of standard medical care. This proposal is based on earlier publications that demonstrated administration of mesenchymal stem/stromal cells produced beneficial effects in animal models of TBI (by MSCs), primarily through reducing inflammation, and the more recent observation by us and another lab that the beneficial effects of MSCs can be reproduced with small vesicles (exosomes) produced by MSCs. The proposed studies will establish the efficacy, safety, and mode of action of A1-exosomes in a mouse model of TBI. A1-exosomes are prepared from MSCs with a scalable protocol, which can be used as “off-the-shelf” reagents. We will compare the administration of A1-exosomes either intravenously or intranasally since we have recently found that intranasal administration of A1-exosomes dramatically reduces induced-neuroinflammation. If successful, the proposal will provide the basis for a novel clinical therapy for TBI and perhaps other diseases involving neuroinflammation such as Parkinsonism and Alzheimer’s disease.

项目总结/文摘

项目成果

期刊论文数量（37）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus.

DOI：
10.1016/j.redox.2021.101973
发表时间：
2021-07
期刊：
Redox biology
影响因子：
11.4
作者：
Madhu LN;Kodali M;Attaluri S;Shuai B;Melissari L;Rao X;Shetty AK
通讯作者：
Shetty AK

Proficiency of Extracellular Vesicles From hiPSC-Derived Neural Stem Cells in Modulating Proinflammatory Human Microglia: Role of Pentraxin-3 and miRNA-21-5p.

DOI：
10.3389/fnmol.2022.845542
发表时间：
2022
期刊：
Frontiers in molecular neuroscience
影响因子：
4.8
作者：
Upadhya R;Madhu LN;Rao S;Shetty AK
通讯作者：
Shetty AK

SARS-CoV-2 and Hypertension: Evidence Supporting Invasion into the Brain Via Baroreflex Circuitry and the Role of Imbalanced Renin-Angiotensin-Aldosterone-System.

DOI：
10.1177/26331055231151926
发表时间：
2023
期刊：
NEUROSCIENCE INSIGHTS
影响因子：
3.6
作者：
Oliveira, Kellysson Bruno;de Melo, Igor Santana;da Silva, Bianca Rodrigues Melo;Oliveira, Keylla Lavinia da Silva;Sabino-Silva, Robinson;Anhezini, Lucas;Katayama, Pedro Lourenco;Santos, Victor Rodrigues;Shetty, Ashok K.;de Castro, Olagide Wagner
通讯作者：
de Castro, Olagide Wagner

Promise of irisin to attenuate cognitive dysfunction in aging and Alzheimer's disease.