Single-Shot Quantitative X-ray Imaging for Interventional Procedures

用于介入手术的单次定量 X 射线成像

• 批准号: 10413114
• 负责人: Adam S Wang
• 金额: $ 19.71万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413114
• 关键词: Abdomen; Address; Adoption; Area; Arteries; Cancer Etiology; Cessation of life; Chemoembolization; Chest; Clinical; Computer software; Deposition; Dose; Doxorubicin; Drug Delivery Systems; Drug Monitoring; Drug usage; Ensure; Image; Intervention; Interventional Imaging; Iodine; Methods; Motion; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Primary Malignant Neoplasm of Liver; Primary carcinoma of the liver cells; Procedures; Radiation Dose Unit; Research; Roentgen Rays; System; Technology; Therapeutic Embolization; Thick; Time; Tissues; Unresectable; X-Ray Medical Imaging; bone; density; design; design and construction; detector; feeding; image guided; image processing; imaging capabilities; imaging modality; imaging system; improved; in vivo; prototype; quantitative imaging; real-time images; response; success; temporal measurement; tool; tumor

Project Abstract Primary liver cancer, and specifically hepatocellular carcinoma (HCC), is the third most common cause of cancer death worldwide. In patients with intermediate-stage or unresectable HCC, transarterial chemoembolization (TACE) is the most widely used therapy. The success of TACE critically depends on the accurate and complete targeting of the tumor. While x-ray image guidance is routinely used to qualitatively visualize the drug delivery, it currently does not enable quantitative guidance and assessment to determine appropriate delivery endpoints. Therefore, TACE endpoints are highly variable across operators and patients, with poor ability to predict tumor response and patient outcome. To accurately monitor drug accumulation in the tumor, real-time quantification of radiopaque iodine (mixed with the drug prior to delivery) is needed with every x-ray image, a concept we entitle single-shot quantitative imaging (SSQI). SSQI is not currently possible due to several challenges with x-ray imaging, including scatter, multiple overlaying materials, and patient and system motion. We therefore propose robust SSQI enabled by the combination of a primary modulator and a dual-layer detector to quantify iodine areal density in real time. The primary modulator provides scatter correction, while the dual-layer detector provides material-specific images with each exposure. The resulting SSQI system provides iodine quantification and dose-efficient grayscale images that are robust against motion. A key strength of the proposed solution is its simplicity in hardware and software – it is compatible with existing system designs, without introducing new complexities or challenges. Our specific aims include: 1) Build a prototype SSQI system. We will design and construct a primary modulator with optimized material, pitch, and thickness, as well as a dual-layer detector with optimized scintillator thicknesses and filter for quantifying iodine in abdominal imaging. We will also develop a real-time image processing pipeline to convert the modulated dual-layer images into quantitative images. 2) Assess the quantitative imaging accuracy of prototype SSQI system. We will evaluate the material quantification accuracy for iodine tasks representative of TACE using phantoms of various sizes with known amounts of iodine, bone, and other tissue-equivalent materials. We hypothesize that SSQI can achieve accurate iodine quantification and grayscale accuracy, while being dose efficient. The proposed studies will establish a new x-ray imaging paradigm that brings quantitation to every image by simultaneously overcoming several current limitations of x-ray imaging while retaining traditional advantages such as high spatial and temporal resolution and large-area imaging. The simplicity and broad applicability of SSQI to x-ray systems has the potential for widespread adoption as a platform for quantitative imaging.

项目摘要 原发性肝癌，特别是肝细胞癌 (HCC)，是第三大常见原因 全球癌症死亡人数。对于中期或不可切除的 HCC 患者，经动脉 化疗栓塞（TACE）是最广泛使用的疗法。 TACE 的成功关键取决于 准确、完整地靶向肿瘤。虽然 X 射线图像引导通常用于定性 可视化药物输送，目前无法进行定量指导和评估来确定 适当的交付端点。因此，TACE 终点在操作者和患者之间存在很大差异， 预测肿瘤反应和患者结果的能力较差。 为了准确监测肿瘤中的药物蓄积，实时定量不透射线的碘（混合碘） 每张 X 射线图像都需要使用药物，这是我们赋予单次定量的概念 成像（SSQI）。由于 X 射线成像面临的一些挑战，包括散射、 多种覆盖材料以及患者和系统运动。因此，我们建议通过以下方式实现稳健的 SSQI： 主调制器和双层检测器的组合可实时量化碘面密度。这 主调制器提供散射校正，而双层探测器提供特定材料的图像 每次曝光。由此产生的 SSQI 系统提供碘定量和剂量有效的灰度 对运动具有鲁棒性的图像。所提出的解决方案的一个关键优势是其硬件简单性和 软件 – 它与现有系统设计兼容，不会引入新的复杂性或挑战。 我们的具体目标包括： 1) 构建原型 SSQI 系统。我们将设计并建造一个初级 具有优化材料、节距和厚度的调制器，以及具有优化闪烁体的双层探测器 用于量化腹部成像中碘的厚度和过滤器。我们还将开发实时图像 将调制的双层图像转换为定量图像的处理管道。 2) 评估 原型 SSQI 系统的定量成像精度。我们将评估材料量化 使用具有已知碘量的各种尺寸的体模代表 TACE 的碘任务的准确性， 骨和其他组织等效材料。我们假设SSQI可以实现准确的碘 定量和灰度精度，同时具有剂量效率。 拟议的研究将建立一种新的 X 射线成像范式，为每张图像带来定量 在保留传统优势的同时，同时克服了当前 X 射线成像的若干限制 例如高空间和时间分辨率以及大面积成像。其简单性和广泛的适用性 SSQI 到 X 射线系统作为定量成像平台具有广泛采用的潜力。

项目成果

Single-Shot Quantitative X-ray Imaging Using a Primary Modulator and Dual-Layer Detector: Simulation and Phantom Studies.

使用主调制器和双层探测器的单次定量 X 射线成像：模拟和模型研究。

• DOI: 10.1117/12.2611591
• 发表时间: 2022
• 期刊: Proceedings of SPIE--the International Society for Optical Engineering
• 作者: Shi,Linxi;Bennett,NRobert;Wang,AdamS
• 通讯作者: Wang,AdamS