iCare - Integrated assessment and Advanced Characterisation of Neuro-Nanotoxicity

由于纳米材料的发明、生产和使用呈指数级增长，人造纳米材料的偶然、意外或故意释放到环境中并暴露于人类是不可避免的。它会对我们的健康产生巨大的影响，特别是对最敏感和暴露的人体器官，如肺、胃和大脑。iCare的目标是开发一套具有弹性和适应性的先进成像技术，以量化复杂矩阵中ANMC的物理化学性质。主要目标将集中在一个集成的模型系统，以表征和预测纳米材料对大脑健康的影响，以防止纳米材料的毒性。该项目为工业界提供了一套技术和方法，用于评估纳米材料暴露于模拟环境和生物暴露的复杂均质基质时形貌、化学成分和反应性的变化，特别强调高分辨率成像方法。为了实现这一目标，该项目在联盟中汇集了来自不同背景的11位合作伙伴，如来自不同欧盟和非欧盟国家的rto、中小企业、工业和大学，以及来自不同领域的合作伙伴，如纳米技术、毒理学、先进材料、先进成像……在48个月的项目期间，联盟将致力于开发不同的活动，以实现以下结果：1)新的成像方法，实现新的高分辨率方法和新的超分辨率成像技术2)毒理学测试方案的发展，解决纳米毒理学目前的差距，3)工具和方法的发展，带来体外和体内测试的差距，4)材料和产品开发的效率5)提供可靠的数据和改进的数据报告，最后发展统一的标准化测试方法，可以在监管框架中使用。

The incidental, accidental, or intentional release of manufactured nanomaterials into the environment and its exposure to humans is inevitable due to the exponential growth in invention, production, and use of them. It can have a huge impact in our health specially in the most sensible and exposed human body organs such us lungs, stomach, and brain. iCare aim to to develop a resilient and adaptive set of advanced imaging technologies to quantify physical-chemistry properties for ANMC in complex matrices. The main objective will focus on a integrated model system to characterize and predict the impact of nanomaterials on brain health to prevent the toxicity nanomaterials. The project makes accessible for industry a set of techniques and methodologies to evaluate changes in morphology, chemical composition and reactivity of nanomaterials when exposed to complex homogenous matrices mimicking environmental and biological exposure, with a particular emphasis on high-resolution imaging methodologies. To achieve this goal the project the project brings together in the consortium 11 partners from different backgrounds such as RTOs, SMEs, industries and universities from different EU and non-eu countries and coming from different fields like nanotech, toxicology, advanced materials, advanced imaging, … During the 48 months long of the project, the consortium will work on the development of different activities to achieve the following results: 1)new imaging methods achieving new high resolution methodologies and new super resolution imaging techniques 2)development of toxicology testing protocols and addressing current gaps in nanotoxicology, 3)development of tools and methods bringing the gap in vitro and in vivo testing, 4)efficiency of materials and product development 5)Delivery of reliable data and improved data reporting and finally development of harmonised standardised test methods that can be used in regulatory frameworks.