INSIGHT: Integrated Models for the Development and Assessment of High Impact Chemicals and Materials

安全和可持续设计（SSbD）化学品和材料是解决现代社会挑战的关键。然而，缺乏利益相关者的协调，相关数据的有限获取，以及缺乏标准化的方法，因此阻碍了SSbD综合方法的出现。INSIGHT将通过开发化学品/材料的机械影响评估的创新框架来克服这些挑战。INSIGHT框架将由多层方法组成，该方法集成了数据、模型和影响结果路径（IOP）图。INSIGHT还将提供精心策划和用户友好的FAIR数据和计算模型/工作流程。INSIGHT旨在促进化学品和材料可持续性和安全性评估的范式转变，从分散的情况到整体和综合的方法。INSIGHT将提供决策地图，作为其综合框架的一部分，指导用户完成决策过程，帮助他们以更有效和全面的方式评价化学品/材料的社会、经济、健康和环境影响。INSIGHT项目完全符合欧盟的安全和可持续性原则以及欧洲绿色协议。INSIGHT将支持在中立、生物多样性保护、公共卫生和循环经济等领域制定政策，从而帮助发展尊重整个地球的充满活力的经济，避免对人类和环境造成伤害。通过将尖端的人工智能方法应用于SSbD， INSIGHT将推动创新，实现数字化、循环、气候中和和可持续经济。INSIGHT将帮助行业优化化学品/材料及其衍生产品的开发和生产，支持监管机构和政策制定者做出明智的决策，以实现更安全和更可持续的社会，并为全面的SSbD方法铺平道路。

Safe and sustainable by design (SSbD) chemicals and materials are crucial to address the challenges of modern society. However, lack of stakeholders’ coordination, limited accessto relevant data, and absence ofstandardised methods have thusfar hampered the emergence of a comprehensive approach to SSbD. INSIGHT will overcome these challenges by developing an innovative framework for mechanistic impact assessment of chemicals/materials. The INSIGHT framework will consist of a multi-layered approach that integrates data, models, and impact outcome pathway (IOP) graphs. INSIGHT will also provide curated and user-friendly FAIR data and computational models/ workflows. INSIGHT aims to foster a paradigm shift in the assessment of sustainability and safety of chemicals and materials, from a fragmented situation to a holistic and integrated approach. INSIGHT will provide decision maps as a part of its integrated framework to guide users through the decision-making process, aiding them in evaluating the social, economic, health and environmental impacts of chemicals/materials in a more efficient and comprehensive manner. The INSIGHT project is fully aligned with the EU principles of safety and sustainability and the European Green Deal. INSIGHT will support the development of policies in the areas of neutrality, biodiversity protection, public health, and circular economy, thus aiding the development of a dynamic economy respecting planet Earth as a whole, avoiding harm to humans and the environment. By democratising the use of cutting-edge AI methods to SSbD, INSIGHT will drive innovation towards a digital, circular, climate-neutral and sustainable economy. INSIGHT will help the industry to optimise development and production of chemicals/materials and derived products, support regulators and policymakers in informed decision making towards safer and more sustainable society, and pave the way for a comprehensive approach to SSbD.