Theory and Modeling of the Orofacial Active Sensation

项目4.摘要 口面部主动感觉的理论和模型(Golomb as Lead；Freund；Kleinfeld) 这项研究项目致力于主动感知的感觉运动脑干电路的动力学。 我们最初的关注点是触觉系统，给出了口腔面部这方面的相对过多的信息。 行为。我们模型中的特定元素包括触觉、触觉马达植物和感觉和 运动神经节和核团。我们将使用理论和计算技术来描述 几个“组成部分”的活动，以及对知觉具有很大共性的是，主动反馈如何改变自然 作为主动感觉的结果的感觉输入。 首先，我们将分析振动器和电机装置的相互作用，特别是接触如何影响 电机装置和触点上的力和力矩。然后，我们将机械力的转换量化 触须运动时三叉神经节神经元触须毛囊中神经元放电的信号 与物体接触。在运动脑干水平上，我们探索了放电的产生和同步 运动神经元和前运动神经元的模式，以及前Bötzinger复合体对它们的重置。最后，我们会 构建较大脑干环路的模型，并探索感觉信号如何控制运动的一般问题 行为过程中的活动。 我们的模型将受到研究项目1的连接数据和有关以下方面的生理数据的限制 研究项目2和项目3中口腔探查回路的激活和操作，以及它们的 预测将在研究项目2和3中得到验证。

Project 4. Abstract Theory and modeling of the orofacial active sensation (Golomb as lead; Freund; Kleinfeld) This Research Project addresses the dynamics of the sensorimotor brainstem circuits for active sensing. Our initial focus is on the vibrissae system, given the relative plethora of information on this aspect of orofacial behavior. The specific elements in our model include the vibrissae, the vibrissa motor plant, and sensory and motor neuronal ganglia and nuclei. We will use theoretical and computational techniques to describe the activity of several "Components" and, of great generality to perception, how active feedback alters the nature of the sensory input as a consequence ofs active sensing. First we will analyze the interaction of the vibrissae and the motor plant, specifically how contact effects the motor plant and the forces and torques on the vibrissae. We then quantify the transformation of mechanical signals in whisker follicle to neuronal spiking of trigeminal ganglion neurons during vibrissa movement and touch with object. At the motor brainstem level, we explore the generation and synchronization of firing patterns of motoneurons and pre-motoneurons, and their reset by the pre-Bötzinger complex. Finally, we will construct models of larger brainstem loops and explore general issues of how sensory signals control motor activity during behavior. Our models will be constrained by connectivity data from Research Project 1 and physiological data about the activation and operation of orofacial exploratory circuitry from Research Project 2 and 3, and their predictions will be tested in Research Project 2 and 3.