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Theory and Modeling of the Orofacial Active Sensation

口面部主动感觉的理论和建模

基本信息

批准号：
10413917
负责人：
David Golomb
金额：
$ 33.71万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-15 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10413917
关键词：
Address Affect Air Anatomy Behavior Behavioral Brain Stem Cell Nucleus Code Complex Computational Technique Computer Models Data Elements Esthesia Exploratory Behavior Feedback Fire - disasters Future Ganglia Generations Goals Head Movements Lead Measures Mechanics Mechanoreceptors Modeling Motor Motor Activity Motor Neurons Movement Muscle Nature Neurologic Neuromechanics Neurons Nose Pattern Perception Periodicity Physiological Plant Model Plants Positioning Attribute Property Psychological Techniques Pump Research Project Grants Reverse engineering Scheme Sensory Sensory Ganglia Signal Transduction Structure of trigeminal ganglion Synapses System Testing Time Torque Touch sensation Vibrissae Work active control base chemical property computer framework design electrical property experimental study improved mechanical properties mechanical signal motor control neuroregulation operation orofacial predictive modeling response sensory input theories vocalization

项目摘要

Project 4. Abstract Theory and modeling of the orofacial active sensation (Golomb as lead; Freund; Kleinfeld) This Research Project addresses the dynamics of the sensorimotor brainstem circuits for active sensing. Our initial focus is on the vibrissae system, given the relative plethora of information on this aspect of orofacial behavior. The specific elements in our model include the vibrissae, the vibrissa motor plant, and sensory and motor neuronal ganglia and nuclei. We will use theoretical and computational techniques to describe the activity of several "Components" and, of great generality to perception, how active feedback alters the nature of the sensory input as a consequence ofs active sensing. First we will analyze the interaction of the vibrissae and the motor plant, specifically how contact effects the motor plant and the forces and torques on the vibrissae. We then quantify the transformation of mechanical signals in whisker follicle to neuronal spiking of trigeminal ganglion neurons during vibrissa movement and touch with object. At the motor brainstem level, we explore the generation and synchronization of firing patterns of motoneurons and pre-motoneurons, and their reset by the pre-Bötzinger complex. Finally, we will construct models of larger brainstem loops and explore general issues of how sensory signals control motor activity during behavior. Our models will be constrained by connectivity data from Research Project 1 and physiological data about the activation and operation of orofacial exploratory circuitry from Research Project 2 and 3, and their predictions will be tested in Research Project 2 and 3.

项目4。摘要