International Symposia on Recent Advances in Otitis Media

中耳炎最新进展国际研讨会

• 批准号: 10413954
• 负责人: Lauren O Bakaletz
• 金额: $ 3.99万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-04 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413954
• 关键词: Acute; Address; Adolescent; Antibiotics; Area; Authorization documentation; Bacterial Antibiotic Resistance; Basic Science; Bioinformatics; Biomedical Engineering; Biotechnology; Books; California; Child; Childhood; Chronic; Clinical; Clinical Nurse Specialists; Collaborations; Communication; Communication impairment; Complex; Destinations; Development; Diagnosis; Discipline; Disease; Education; Ensure; Epigenetic Process; Eustachian Tube; Evaluation; Event; Faculty; Family Caregiver; Feedback; Financial Support; Fostering; Functional disorder; Funding; Future; Future Generations; Genetic; Goals; Healthcare; Healthy People 2020; Hearing; Hyperplasia; Immune; Immunologics; Immunology; Infection; Inflammation; International; Israel; Journals; Knowledge; Laboratories; Licensure; Life; Link; Los Angeles; Mentorship; Microbe; Microbial Biofilms; Modeling; Molecular; Mucous Membrane; Mucous body substance; National Institute on Deafness and Other Communication Disorders; Natural Immunity; Nature; Ohio; Oral; Otitis Media; Participant; Pathogenesis; Pathway interactions; Patients; Peer Review; Postdoctoral Fellow; Predisposition; Prevalence; Prevention strategy; Production; Public Health; Publications; Quality of life; Recommendation; Reflux; Reporting; Research; Research Personnel; Research Priority; Resolution; Scholarship; Schools; Senior Scientist; Sensory Disorders; Services; Societies; Speed; Strategic Planning; Structure; Students; Sweden; Talents; Targeted Research; Technology; Time; Underrepresented Minority; Upper Respiratory Infections; Vaccination; Vaccines; Work; accurate diagnosis; animal model development; base; burden of illness; care burden; career; cost; disadvantaged population; improved; innovation; interest; microbial; microbiome; middle ear; minority scientist; new therapeutic target; outreach; patient advocacy group; posters; precision genomic medicine; prevent; programs; social media; socioeconomics; success; symposium; systematic review; targeted treatment; tissue repair

PROJECT SUMMARY Partial support is being requested for three International Symposia on Recent Advances in Otitis Media. The worldwide prevalence of otitis media (OM) and alarming increase in antibiotic resistant bacteria that cause OM make this a serious public health problem. Thus, there is a pressing need for better ways to diagnose, treat and ultimately, prevent OM. To do so however requires a complete understanding of all aspects of this pediatric disease, a stated goal of both Healthy People 2020 (Hearing and Other Sensory or Communication Disorders, ENT-VSL-2: “Reduce otitis media in children and adolescents”), and the NIDCD strategic plan FY 2017-2021, wherein Priority Area 2 – Understanding Diseases and Disorders, declares a mandate to improve our understanding of the susceptibility and pathogenesis of OM as related to genetics, prior upper respiratory tract infection, Eustachian tube dysfunction and reflux, bacterial biofilms and microbiome, polymicrobial infections, dysregulation of innate immunity, inflammation and mucus production, mucosal hyperplasia and dysregulation of the resolution of inflammation and tissue repair. Defining the immune pathways for effective middle ear protection by vaccines and identification of new therapeutic targets as well as development of animal models of acute and chronic OM, determination of the impact of vaccination on disease prevalence and infection by other microbes are also cited as major goals within this priority research area. The objectives of the International Symposia on Recent Advances in Otitis Media are fully and uniquely aligned with these strategic goals. We strongly believe that the speed of scientific discovery requires regular broad and in-depth review of the research progress in OM every two years. Importantly, an additional opportunity to define and formulate recommendations for future research directions and funding every four years by the convening of an integrated Research Conference within the Symposium (occurs during U.S.-convened symposia) is also of great value to our collective efforts to identify and promote new and innovative research opportunities. Thereby, with permission and recommendation from NIDCD staff, herein we request support that will span a period of 5 years, during which we will convene the 20th , 21st and 22nd International Symposia on Recent Advances in Otitis Media (in 2019, 2021 and 2023, respectively). The 20th Symposium will be convened June 9-13 in Los Angeles, California; the 21st Symposium will be convened June 6-10 in Tel Aviv, Israel; and the 22nd Symposium will be convened at a U.S. destination that will be decided at the 20th Symposium. These Symposia are expected to foster improved communication amongst diverse research disciplines in the OM research field and help close gaps in our collective knowledge and understanding of the pathogenesis as well as the diagnosis, treatment and/or potential for immunological resolution of OM. This Symposium has also consistently attracted young investigators from many disciplines and from around the world, thus ensuring a future generation of both basic science and clinician investigators who will continue to move the field forward.

项目摘要 关于中耳炎的最新进展，要求进行部分支持进行三个国际研讨会。这 在全球中耳炎（OM）的患病率和引起OM的抗生素耐药细菌的惊人增加 使这成为严重的公共健康问题。那是迫切需要更好的诊断方法 最终，防止OM。但是，要这样做需要完全理解此方面的各个方面 儿科疾病是2020年健康人的既定目标（听力和其他感觉或交流） 疾病，ENT-VSL-2：“减少儿童和青少年的中耳炎”）和NIDCD战略计划FY 2017-2021，其中优先区域2 - 了解疾病和疾病，宣布了改善的任务 我们对与遗传学有关的OM的易感性和发病机理的理解，先前的上呼吸道 道感染，尤斯塔克扬管功能障碍和反射症，细菌生物膜和微生物组，多菌菌 感染，先天免疫失调，感染和粘液产生，粘膜增生和 感染和组织修复分辨率的失调。定义有效的免疫途径 通过疫苗保护中耳保护和确定新的治疗靶标的 急性和慢性OM的动物模型，确定疫苗接种对疾病患病率的影响 其他微生物的感染也被认为是该优先研究领域内的主要目标。目标的目标 有关中耳炎媒体最新进展的国际研讨会与这些介质的最新进展完全合成 战略目标。我们坚信，科学发现的速度需要定期广泛而深入 每两年审查一次OM的研究进展。重要的是，定义和 通过召集每四年为未来的研究指示和资助的建议 研讨会内的综合研究会议（发生在美国召开的研讨会期间）也是 我们的集体努力非常重视，以识别和促进新的和创新的研究机会。 因此，在NIDCD员工的许可和建议下，我们在此要求提供支持的支持 5年的期间，在此期间，我们将在最近的20、21和22届国际研讨会上召集 中耳炎的进展（分别在2019年，2021年和2023年）。第20次研讨会将于6月召集 9-13在加利福尼亚州洛杉矶；第21届研讨会将于6月6日至10日在以色列特拉维夫举行。和 第22届研讨会将在美国目的地召集，该目的地将在第20届研讨会上决定。这些 预计专题讨论会在OM中促进潜水员研究学科之间的沟通 研究领域并有助于弥合我们的集体知识和对发病机理的理解 作为诊断，治疗和/或潜在的OM免疫学分辨率。该研讨会也有 一贯吸引来自许多学科和世界各地的年轻调查员，从而确保 基础科学和临床研究人员的未来一代，他们将继续向前推进该领域。