Acquisition of Inductively Coupled Plasma Mass Spectrometry for Elemental Analysis

获取用于元素分析的电感耦合等离子体质谱仪

• 批准号: 10415598
• 负责人: Kun Lu
• 金额: $ 19.47万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415598
• 关键词: 14 year old; Biological Markers; Core Facility; Detection; Elements; Engineering; Equipment; Excision; Funding; Grant; Human Resources; Inductively Coupled Plasma Mass Spectrometry; Leadership; Mass Spectrum Analysis; Measurement; Metals; Minor; Modeling; Performance; Research; Research Personnel; Resources; Sampling; Services; Specialist; Technical Expertise; Time; United States National Institutes of Health; base; experience; instrumentation; research facility; success

PROJECT SUMMARY / ABSTRACT The S10 proposal seeks funding to purchase a new Agilent 8900 Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to replace our 14-year-old Agilent 7500 ICP-MS, which has been out of order since December 2020. The new ICP-MS will be housed in the Biomarker Mass Spectrometry Facility (BMSF), a shared UNC research facility that has successfully served the campus for over two decades. As an obsolete model, our 7500 ICP-MS was deemed unrepairable by Agilent service engineers. The 7500 ICP-MS, purchased with institutional funds in 2008, has been the workhorse equipment in the Facility and supported NIH grants totaling over $30 million in the last decade, demonstrating outstanding past performance of the ICP-MS at the BMSF to support funded research. The 7500 ICP-MS at the BMSF is the only shared ICP-MS resource on UNC campus. Unavailability of ICP-MS is very disruptive among our users and investigators, threatening the timely completion of active NIH-funded projects (~$18 million in next 5 years). Agilent ICP-MS remains best of its kind and Agilent 8900 ICP-MS has superb sensitivity and interference removal to enable the detection and quantitation of elements in diverse sample matrices with ultratrace levels of metals. The BMSF has great technical expertise in operating the ICP-MS, with a dedicated highly experienced research specialist. Dr. Lu, the Director of the BMSF, has over 15 years of experience in the mass spectrometry and metal analysis with ICP-MS, who has also established leadership in overseeing and managing research facilities/cores to support investigators in diverse fields. Selected 13 NIH-funded projects from 7 major (~76% AUT) and 3 minor users (~10% AUT), as outlined in this proposal, all have significant and urgent needs for state-of-the-art ICP-MS for sensitive elemental analysis. Our two decades of success has unequivocally established the BMSF as a key player in exposure measurement with ICP-MS. With everything in place at the BMSF, including unparalleled sensitive instrumentation, highly experienced personnel, a large user base, a strong leadership team and institutional commitment, the requested 8900 ICP-MS will continuously succeed as a valuable and unique resource to serve UNC and beyond.

项目概要/摘要 S10 提案寻求资金购买新的 Agilent 8900 电感耦合等离子体质量 光谱测定法 (ICP-MS) 取代了已有 14 年历史的 Agilent 7500 ICP-MS，该仪器自此以来一直处于故障状态 2020 年 12 月。新的 ICP-MS 将安装在生物标记质谱设施 (BMSF) 中，该设施是一个共享的 北卡罗来纳大学的研究设施已成功为校园服务了二十多年。作为一个过时的模型，我们的 安捷伦服务工程师认为 7500 ICP-MS 无法修复。 7500 ICP-MS，购买时附带 2008 年机构资金，一直是该设施的主力设备，并支持 NIH 拨款总计 过去十年中花费超过 3000 万美元，展示了 BMSF ICP-MS 过去的出色表现 支持资助的研究。 BMSF 的 7500 ICP-MS 是 UNC 校园内唯一的共享 ICP-MS 资源。 ICP-MS 的不可用对我们的用户和研究人员来说非常具有破坏性，威胁到及时完成 NIH 资助的活跃项目（未来 5 年约 1800 万美元）。安捷伦 ICP-MS 仍然是同类产品中的佼佼者，安捷伦 8900 ICP-MS 具有卓越的灵敏度和干扰消除能力，能够检测和定量 各种样品基质中含有超痕量金属的元素。 BMSF 在以下方面拥有丰富的技术专长： 由经验丰富的专门研究专家操作 ICP-MS。尊敬的BMSF主任卢博士， 在使用 ICP-MS 进行质谱分析和金属分析方面拥有超过 15 年的经验， 在监督和管理研究设施/核心方面建立领导地位，以支持不同领域的研究人员 字段。如概述的，从 7 个主要用户（~76% AUT）和 3 个次要用户（~10% AUT）中选择了 13 个 NIH 资助的项目 在该提案中，所有人都对最先进的 ICP-MS 进行敏感元素分析有着重大而迫切的需求。 我们二十年的成功已经明确地将 BMSF 确立为暴露测量领域的关键参与者 ICP-MS。 BMSF 的一切都已就位，包括无与伦比的灵敏仪器，高度 经验丰富的人员、庞大的用户群、强大的领导团队和制度承诺， 8900 ICP-MS 将作为宝贵而独特的资源不断取得成功，为 UNC 及其他地区提供服务。