Acquisition of Inductively Coupled Plasma Mass Spectrometry for Elemental Analysis

项目摘要/摘要 S10提案寻求资金购买新的安捷伦8900电感耦合等离子体质量 更换我们已有14年历史的安捷伦7500电感耦合等离子体质谱(ICP-MS)，后者自 2020年12月。新的电感耦合等离子体质谱将被安置在生物标记质谱仪(BMSF)中，这是一个共享的 北卡罗来纳大学的研究机构，已经成功地为校园服务了20多年。作为一款过时的车型，我们的 安捷伦服务工程师认为7500个电感耦合等离子体质谱仪是无法修复的。随附购买的7500电感耦合等离子体质谱 2008年的机构资金，一直是该机制的主力设备，并支持NIH赠款总额 在过去十年中超过3000万美元，展示了BMSF的ICPMS过去的出色表现，以 支持资助研究。BMSF的7500个电感耦合等离子体质谱仪是北卡罗来纳大学校园内唯一共享的电感耦合等离子体质谱仪资源。 无法获得电感耦合等离子体质谱对我们的用户和调查人员来说是非常混乱的，威胁到及时完成 美国国立卫生研究院资助的在建项目(未来5年约1800万美元)。安捷伦电感耦合等离子体质谱保持同类中的最好水平 8900电感耦合等离子体质谱具有极高的灵敏度和干扰消除能力，能够检测和定量 不同样品基质中的元素具有超痕量的金属。BMSF在以下方面拥有丰富的技术专长 操作电感耦合等离子体质谱仪，有一位经验丰富的专门研究专家。卢博士，BMSF主任， 在电感耦合等离子体质谱和金属分析方面有超过15年的经验，他还 在监督和管理研究设施/核心方面建立领导地位，以支持不同领域的研究人员 菲尔兹。从7个主要用户(约76%的AUT)和3个次要用户(约10%的AUT)中挑选出13个NIH资助的项目，概述如下 在这项提案中，所有人都对用于灵敏元素分析的最先进的电感耦合等离子体质谱有重大和迫切的需求。 我们二十年的成功使BMSF明确地成为暴露测量领域的关键参与者 与电感耦合等离子体质谱联用。随着BMSF的一切就绪，包括无与伦比的灵敏仪器，高度 经验丰富的人员，庞大的用户基础，强大的领导团队和机构承诺，所要求的 8900国际电感耦合等离子体质谱将继续成为为北卡罗来纳大学及其他地区提供服务的宝贵而独特的资源。

PROJECT SUMMARY / ABSTRACT The S10 proposal seeks funding to purchase a new Agilent 8900 Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to replace our 14-year-old Agilent 7500 ICP-MS, which has been out of order since December 2020. The new ICP-MS will be housed in the Biomarker Mass Spectrometry Facility (BMSF), a shared UNC research facility that has successfully served the campus for over two decades. As an obsolete model, our 7500 ICP-MS was deemed unrepairable by Agilent service engineers. The 7500 ICP-MS, purchased with institutional funds in 2008, has been the workhorse equipment in the Facility and supported NIH grants totaling over $30 million in the last decade, demonstrating outstanding past performance of the ICP-MS at the BMSF to support funded research. The 7500 ICP-MS at the BMSF is the only shared ICP-MS resource on UNC campus. Unavailability of ICP-MS is very disruptive among our users and investigators, threatening the timely completion of active NIH-funded projects (~$18 million in next 5 years). Agilent ICP-MS remains best of its kind and Agilent 8900 ICP-MS has superb sensitivity and interference removal to enable the detection and quantitation of elements in diverse sample matrices with ultratrace levels of metals. The BMSF has great technical expertise in operating the ICP-MS, with a dedicated highly experienced research specialist. Dr. Lu, the Director of the BMSF, has over 15 years of experience in the mass spectrometry and metal analysis with ICP-MS, who has also established leadership in overseeing and managing research facilities/cores to support investigators in diverse fields. Selected 13 NIH-funded projects from 7 major (~76% AUT) and 3 minor users (~10% AUT), as outlined in this proposal, all have significant and urgent needs for state-of-the-art ICP-MS for sensitive elemental analysis. Our two decades of success has unequivocally established the BMSF as a key player in exposure measurement with ICP-MS. With everything in place at the BMSF, including unparalleled sensitive instrumentation, highly experienced personnel, a large user base, a strong leadership team and institutional commitment, the requested 8900 ICP-MS will continuously succeed as a valuable and unique resource to serve UNC and beyond.