Acquisition of Inductively Coupled Plasma Mass Spectrometry for Elemental Analysis

获取用于元素分析的电感耦合等离子体质谱仪

• 批准号: 10415598
• 负责人: Kun Lu
• 金额: $ 19.47万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415598
• 关键词: 14 year old; Biological Markers; Core Facility; Detection; Elements; Engineering; Equipment; Excision; Funding; Grant; Human Resources; Inductively Coupled Plasma Mass Spectrometry; Leadership; Mass Spectrum Analysis; Measurement; Metals; Minor; Modeling; Performance; Research; Research Personnel; Resources; Sampling; Services; Specialist; Technical Expertise; Time; United States National Institutes of Health; base; experience; instrumentation; research facility; success

PROJECT SUMMARY / ABSTRACT The S10 proposal seeks funding to purchase a new Agilent 8900 Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to replace our 14-year-old Agilent 7500 ICP-MS, which has been out of order since December 2020. The new ICP-MS will be housed in the Biomarker Mass Spectrometry Facility (BMSF), a shared UNC research facility that has successfully served the campus for over two decades. As an obsolete model, our 7500 ICP-MS was deemed unrepairable by Agilent service engineers. The 7500 ICP-MS, purchased with institutional funds in 2008, has been the workhorse equipment in the Facility and supported NIH grants totaling over $30 million in the last decade, demonstrating outstanding past performance of the ICP-MS at the BMSF to support funded research. The 7500 ICP-MS at the BMSF is the only shared ICP-MS resource on UNC campus. Unavailability of ICP-MS is very disruptive among our users and investigators, threatening the timely completion of active NIH-funded projects (~$18 million in next 5 years). Agilent ICP-MS remains best of its kind and Agilent 8900 ICP-MS has superb sensitivity and interference removal to enable the detection and quantitation of elements in diverse sample matrices with ultratrace levels of metals. The BMSF has great technical expertise in operating the ICP-MS, with a dedicated highly experienced research specialist. Dr. Lu, the Director of the BMSF, has over 15 years of experience in the mass spectrometry and metal analysis with ICP-MS, who has also established leadership in overseeing and managing research facilities/cores to support investigators in diverse fields. Selected 13 NIH-funded projects from 7 major (~76% AUT) and 3 minor users (~10% AUT), as outlined in this proposal, all have significant and urgent needs for state-of-the-art ICP-MS for sensitive elemental analysis. Our two decades of success has unequivocally established the BMSF as a key player in exposure measurement with ICP-MS. With everything in place at the BMSF, including unparalleled sensitive instrumentation, highly experienced personnel, a large user base, a strong leadership team and institutional commitment, the requested 8900 ICP-MS will continuously succeed as a valuable and unique resource to serve UNC and beyond.

项目总结/摘要 S10提案寻求资金购买新的Agilent 8900电感耦合等离子体质谱仪 光谱分析（ICP-MS），以取代我们的14岁的安捷伦7500 ICP-MS，这已经出了故障，因为 2020年12月新的ICP-MS将被安置在生物标志物质谱设施（BMSF），一个共享的 该研究设施已成功地为校园服务了二十多年。作为一种过时的模式，我们的 Agilent服务工程师认为7500 ICP-MS无法维修。7500 ICP-MS，购买 在2008年的机构基金，一直是主力设备的设施和支持国家卫生研究院赠款总额 在过去的十年中超过3000万美元，证明了BMSF的ICP-MS过去的出色表现， 资助研究。在BMSF的7500 ICP-MS是唯一的共享ICP-MS资源在校园。 ICP-MS的不可用在我们的用户和研究人员中非常具有破坏性，威胁到及时完成 美国国立卫生研究院资助的活跃项目（未来5年约1800万美元）。安捷伦ICP-MS仍然是同类产品中的佼佼者， 8900型ICP-MS具有极高的灵敏度和干扰消除能力，能够检测和定量 不同样品基质中的元素与超痕量金属。BMSF拥有丰富的技术专长， 操作ICP-MS，有一位经验丰富的研究专家。卢博士，BMSF的主任， 拥有超过15年的质谱和ICP-MS金属分析经验， 建立了监督和管理研究设施/核心的领导能力，以支持不同领域的研究人员 领域的从7个主要用户（约76% AUT）和3个次要用户（约10% AUT）中选择了13个NIH资助的项目，如所述 在这项提议中，所有这些国家都迫切需要最先进ICP-MS进行灵敏的元素分析。 我们二十年的成功已经明确确立了BMSF作为曝光测量的关键参与者 随着BMSF的一切就绪，包括无与伦比的灵敏仪器， 经验丰富的人员、庞大的用户群、强有力的领导团队和机构承诺， 8900 ICP-MS将继续成功地作为一个宝贵的和独特的资源，为客户和超越。