Polycomb Group Proteins - Shaping Chromatin Architecture to Silence Genes

多梳蛋白 - 塑造染色质结构以沉默基因

• 批准号: DE210101669
• 负责人: Dr Michael Uckelmann
• 金额: $ 30.29万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-14 至 2024-01-13
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE210101669
• 关键词: Polycomb; Group; Proteins; Shaping; Chromatin

This project aims to address the fundamental question of how genes are switched off by studying a group of molecular off-switches, the polycomb group proteins. The project is expected to generate new knowledge in the area of gene regulation and epigenetics by combining innovative methods of structural biology and cell biology in an interdisciplinary way. The expected outcomes include a more complete picture of the molecular mechanisms that regulate gene expression and the development of novel methods to image the genome. This should provide significant benefits, such as facilitated development of gene editing tools and regulatory circuits for synthetic biology, as well as novel capabilities to image the genome at high resolution

该项目旨在通过研究一组分子关闭开关（polycomb group protein）来解决基因如何关闭的基本问题。该项目预计将通过以跨学科的方式结合结构生物学和细胞生物学的创新方法，在基因调控和表观遗传学领域产生新的知识。预期的成果包括更完整地了解调控基因表达的分子机制，以及开发新的基因组成像方法。这应该会带来显著的好处，例如促进基因编辑工具和合成生物学调控电路的开发，以及以高分辨率对基因组进行成像的新能力。