Coordinating center for collaborative marmoset research

狨猴协作研究协调中心

• 批准号: 10416064
• 负责人: DONALD F. CONRAD
• 金额: $ 62万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10416064
• 关键词: Acute; Address; Adoption; Agreement; American; Animal Model; Animals; BRAIN initiative; Behavior; Biology; Breeding; Callithrix; Callithrix jacchus jacchus; Censuses; Cognition; Collaborations; Communication; Communities; Country; Data; Data Aggregation; Data Management Resources; Discipline; Equipment and supply inventories; Evaluation; Event; Foundations; Funding; Gene Targeting; Genetic; Genotype; Genotype-Tissue Expression Project; Human Resources; Individual; Informatics; Infrastructure; Intake; Internet; Laboratories; Letters; Manuals; Mental disorders; Methodology; Modeling; Neurosciences; Neurosciences Research; Oregon; Population; Practice Guidelines; Primates; Production; Protocols documentation; Research; Research Personnel; Resources; Scientist; Services; Structure; System; Time; United States; United States National Institutes of Health; Update; Wisconsin; Zoology; base; data resource; design; experience; genetic information; genetic manipulation; genetic pedigree; genome editing; interest; nonhuman primate; programs; research study; statistics; web portal; web site

PROJECT SUMMARY/ABSTRACT The common marmoset (Callithrix jacchus) has emerged as a critically important and tractable non-human primate (NHP) model for neuroscience research accommodating genetic manipulation and directed breeding. Several barriers to the adoption of marmoset models by the neuroscience community exist, including a small census size in the United States (fewer than 2,500 animals), poor communication about resource availability, a poor understanding of the strengths and limitations of marmosets in research, and a lack of a formal structure for coordinating the sharing of information and resources related to marmoset research. In this application, we propose to establish a Marmoset Coordinating Center (MCC) as part of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative that will address these limitations by building upon our experience in NHP informatics and marmoset research. As the foundation for the MCC, we will build a new informatics framework for coordinating marmoset research based on the LabKey data management system. This infrastructure will be derived from the existing LabKey system in place at multiple National Primate Research Centers, and which has been optimized for NHP research, including marmosets, over years of production. This informatics system will be initialized with basic statistics on the marmoset laboratory populations provided by participating centers, making pre-recorded, individual-level information that is already recorded more broadly available to the neuroscience community. Demographic and genetic information will be shared and discussed among participating centers, to coordinate marmoset colony management in line with American Zoological Association practice guidelines. Once operational, the MCC will be comprised of two parts: 1) a web-based portal to provide access to the marmoset data resources stored in LabKey, as well as background content on marmoset biology and neuroscience; 2) a concierge comprised of MCC staff and augmented by a scientific advisory board of marmoset neuroscience experts. The website will provide summaries of existing marmoset neuroscience projects, and allow interested investigators to search animal inventory and request animals. The concierge will be available to answer basic questions about the Center and the use of marmosets in neuroscience. Together, the data and human resources of the MCC will provide an essential portal into marmoset neuroscience research through collaboration, service agreement, or animal transfer.

项目概要/摘要 普通狨猴（Callithrix jacchus）已成为一种极其重要且易于驯服的非人类动物。 用于神经科学研究的灵长类动物（NHP）模型，可进行遗传操作和定向育种。 神经科学界采用狨猴模型存在一些障碍，包括一小部分 美国的人口普查规模（少于 2,500 只动物）、关于资源可用性的沟通不畅、 对狨猴研究中的优势和局限性了解甚少，并且缺乏正式的结构 协调与狨猴研究相关的信息和资源共享。 在此申请中，我们建议建立狨猴协调中心（MCC）作为 NIH 大脑的一部分 通过推进创新神经技术 (BRAIN) 计划进行的研究将解决这些局限性 基于我们在 NHP 信息学和狨猴研究方面的经验。作为MCC的基础，我们 将基于 LabKey 数据建立一个新的信息学框架来协调狨猴研究 管理系统。该基础设施将源自多个地方现有的 LabKey 系统 国家灵长类研究中心，已针对 NHP 研究进行了优化，包括狨猴、 经过多年的生产。该信息学系统将使用狨猴的基本统计数据进行初始化 参与中心提供的实验室人群，制作预先记录的个人信息 已经记录在案，可供神经科学界更广泛地使用。人口统计和遗传 信息将在参与中心之间共享和讨论，以协调狨猴群体 管理符合美国动物协会实践指南。 一旦投入运行，MCC 将由两部分组成：1) 一个基于 Web 的门户，用于提供对 LabKey 中存储的狨猴数据资源，以及狨猴生物学和 神经科学； 2) 由 MCC 工作人员组成的礼宾部，并由狨猴科学顾问委员会加强 神经科学专家。该网站将提供现有狨猴神经科学项目的摘要，以及 允许感兴趣的调查人员搜索动物库存并请求动物。礼宾部将竭诚为您服务 回答有关该中心以及狨猴在神经科学中的应用的基本问题。数据和 MCC 的人力资源将为狨猴神经科学研究提供一个重要的门户 合作、服务协议或动物转移。