A Vevo 3100 Small Animal Ultrasound Machine for the University of Cincinnati

辛辛那提大学的 Vevo 3100 小动物超声机

• 批准号: 10418086
• 负责人: Albert Phillip Owens III
• 金额: $ 40.98万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10418086
• 关键词: 4D Imaging; Anatomy; Animals; Aortic Diseases; Blood Vessels; Cardiac; Cardiovascular system; Clinical Research; Communities; Contract Services; Direct Service Costs; Doctor of Philosophy; Echocardiography; Frequencies; Funding; Future; Heart; Heart Diseases; Heart Rate; Human; Image; Institutes; Kidney Diseases; Lead; Lung; Lung diseases; Measurement; Medical; Morphologic artifacts; Mus; Noise; Oncology; Publications; Reproducibility; Request for Proposals; Research; Research Personnel; Resolution; Scientist; Services; System; Technology; Time; Transducers; Ultrasonography; United States National Institutes of Health; Universities; Visualization; clinical care; cost; end of life; experience; high resolution imaging; improved; in vivo; instrument; repaired; technology development; ultrasound

Project Title: A Vevo 3100 Small Animal Ultrasound Machine for the University of Cincinnati PROJECT SUMMARY/ABSTRACT The current proposal requests funding for upgrading our VisualSonics Vevo 2100 small animal ultrasound machine to a Vevo 3100 system, to be housed and used in the University of Cincinnati Heart, Lung, and Vascular Institute. This system will support the NIH-funded research community at the University of Cincinnati spanning a broad range of investigators from the fields of cardiovascular research in the heart and aorta, lung and kidney diseases, and oncology. The extremely fast heart rate in mice necessitates the use of high frame rates and exceptionally high frequency transducers capable of rapid and high-resolution image acquisition, thus commercially available echocardiography systems for human clinical care and research cannot readily be adapted to provide the temporal and spatial resolution required for detailed assessment of cardiac anatomy and function in mice. At the time of purchase for our original machine (June 2010), the Vevo 2100 system represented the state-of-the-art technology in small animal echocardiography and ultrasound applications that were critical for our researchers to achieve in vivo measurements in their experimental applications and has resulted in more than 60 publications over the last 11 years. Importantly, acquisition of the Vevo 3100 system will markedly improve image quality via the reduction of speckle noise and artifacts allowing for more accurate and reproducible measurements, introduce 4D imaging providing more accurate functional cardiac measurements, and allow faster echocardiography (ECG)-gated kilohertz visualization or EKV, allowing for increased temporal and spatial resolution. Moreover, the Vevo 2100 has received an end-of-life notice from the VisualSonics Corporation and will no longer be maintained, serviced, or repaired as of December 2023. As such, the upgrade to the Vevo 3100 is requested to maintain the high level of in vivo analytics in animal studies at the University of Cincinnati, which are critical to dozens of investigators on the medical campus and open to the University’s other 150 NIH-funded investigators with upwards of 180 million dollars of NIH support annually. Our requested system will be operated by a Ph.D. scientist with 12 years’ experience in all aspects of small animal ultrasonography and this machine is fully supported by the University of Cincinnati to cover the cost of service contracts and technology development to help minimize the direct cost of services to the investigators. Together, proposed use of this instrument will support and enhance existing and future NIH-funded projects and lead to new directions of research for future projects.

项目名称：辛辛那提大学的Vevo 3100小动物超声机 项目总结/摘要 目前的提案要求为升级我们的VisualSonics Vevo 2100小动物超声提供资金 将机器连接到Vevo 3100系统，将在辛辛那提大学心、肺和 血管研究所。该系统将支持辛辛那提大学NIH资助的研究团体 涵盖了来自心脏和主动脉，肺，心血管研究领域的广泛研究人员， 肾脏疾病和肿瘤学。小鼠极快的心率需要使用高帧 能够快速和高分辨率图像采集的超高频换能器， 因此，用于人类临床护理和研究的市售超声心动图系统不能容易地 适合提供详细评估心脏解剖结构所需的时间和空间分辨率 和功能。在购买我们的原始机器时（2010年6月），Vevo 2100系统 代表了小动物超声心动图和超声应用的最新技术， 对于我们的研究人员在实验应用中实现体内测量至关重要， 在过去的11年里，发表了60多篇出版物。Vevo 3100系统的采购 将通过减少斑点噪声和伪影显著改善图像质量， 和可重复的测量，引入4D成像，提供更准确的功能性心脏 测量，并允许更快的超声心动图（ECG）门控千赫兹可视化或EKV， 提高了时间和空间分辨率。此外，Vevo 2100已收到来自 VisualSonics Corporation，并将于2023年12月起不再进行维护，维修或维修。作为 因此，要求升级到Vevo 3100，以保持动物研究中的高水平体内分析 在辛辛那提大学，这是至关重要的数十名调查人员在医学校园和开放， 该大学的其他150名NIH资助的研究人员每年获得NIH超过1.8亿美元的支持。 我们要求的系统将由一位博士操作。科学家，拥有12年的小型 动物超声检查，该机器完全由辛辛那提大学支持，以支付 服务合同和技术开发，以帮助最大限度地减少调查员的直接服务费用。 总之，该工具的拟议使用将支持和加强现有和未来的NIH资助项目 并为未来的项目带来新的研究方向。