Synthra MeIPlus Research with HCN/CO Options and Radchrom Plus for the UAB Cyclotron Facility

项目摘要 该提案寻求支持，以采购和安装新的放射性药物合成器(Synthra Radchrom 此外)能够生产用于临床前(小动物成像)研究和阶段研究的11C-放射性标记药物 影像研究人员的0/I/II临床试验。碳-11显像剂对大多数NIH和 其他联邦和基金会资助了UAB的研究，由于11C的半衰期很短，这些化合物的合成 代理必须在现场进行。该模块将被安置在UAB回旋加速器设施内，并进行维护和 由训练有素的技术人员操作。阿拉巴马大学伯明翰分校做出了重大贡献 对分子成像基础设施的投资，包括TR24回旋加速器、PET/CT和PET MRI 扫描仪和一个完整的GMP放射性药品生产设施，包括一个独立的放射性制药厂。AS 在UAB，使用11C化合物的研究已经大大扩展，新模块将使 11C显像剂的入职和强大的可用性。为了维持和扩大我们现有的 高质量的研究水平并不断取得新的进展，收购Synthra Radchrom Plus对至少8名NIH资助的研究人员和其他一些研究人员至关重要，其中包括 高级调查人员和早期调查人员的混合。新的合成器将支持广泛的11C标记 方法包括直接标记格氏试剂(如制备11C-乙酸酯)和 将11C-二氧化碳转化为11C-甲烷、11C-甲基碘和/或11C-三氟酸甲酯，可用于 对NIH资助的研究很重要的示踪剂，如用于成像的11C-匹兹堡化合物B([11C]PIB) 脑内淀粉样蛋白沉积和11C-UCB-J，用于成像突触小泡糖蛋白2A(SV2A)密度 在神经退行性疾病患者中。这项提议得到了该大学的大力支持， 来自不同部门和中心的专用空间和大量资金(30,000美元)，以帮助支持这一点 进步。继续支持目前正在进行的项目，同时扩大和扩大能力，以 培育新项目是本申请的最终目标。

Project Summary This proposal seeks support to procure and install a new radiopharmaceutical synthesizer (Synthra Radchrom Plus) capable of producing 11C-radiolabeled drugs for preclinical (small animal imaging) studies and for Phase 0/I/II clinical trials for imaging researchers. Carbon-11 imaging agents are essential for multitude of NIH and other federal and foundation funded research at UAB and due to the short half-life of 11C, the synthesis of these agents must occur onsite. The module will be housed within the UAB cyclotron facility and maintained and operated by highly trained technical staff. The University of Alabama at Birmingham has made significant investments in the infrastructure of molecular imaging including a TR24 cyclotron, PET/CT and PET MRI scanners and a full GMP radiopharmaceutical production facility including a standalone, radiopharmacy. As research studies using 11C compounds have greatly expanded at UAB, the new module will enable the onboarding and robust availability of 11C-imaging agents. In order to maintain and expand upon our current level of high-quality research and to continue to make novel advancements, the acquisition of the Synthra Radchrom Plus is critical for at least 8 NIH funded researchers and a number of additional researchers including a mix of senior and early stage investigators. The new synthesizer will support a wide range of 11C-labeling methods including direct labeling of Grignard reagents (such as for the preparation of 11C-Acetate) and conversion of 11C-CO2 to 11C-Methane, 11C-Methyl iodide and/or 11C-Methyl Triflate, which can be used for a tracers important for NIH funded research such as, 11C-Pittsburgh Compound B ([11C]PiB) used for imaging of amyloid deposition in the brain and 11C-UCB-J, used for imaging synaptic vesicle glycoprotein 2A (SV2A) density in patients with neurodegenerative disease. This proposal is being strongly supported by the University with dedicated space and significant funds ($30,000) from a variety of departments and centers to help support this advancement. Continued support of current ongoing projects, while broadening and extending capabilities to foster new projects is the ultimate goal of the present application.