Impacts of nicotinamide riboside on functional capacity and muscle physiology in older Veterans

烟酰胺核苷对老年退伍军人机能和肌肉生理学的影响 越来越多的人在老龄化中看到虚弱 这在很大程度上是由肌肉骨骼的下降推动的。 现在有近900万退伍军人的年龄在65岁或以上 功能能力受损，质量下降 生活质量的提高，以及卫生保健服务和医疗服务使用量的增加 关联成本。据估计，年龄在45-50%以上的人 85只是虚弱的，可能远远超过100万 退伍军人。衰老是导致身体虚弱的重要因素 与烟酰胺水平降低高度相关 腺嘌呤二核苷酸(NAD+)，一种重要的神经营养因子 线粒体功能。细胞内NAD+水平的恢复 获得支持作为一种治疗策略来维持和 甚至在老化过程中增强功能能力。烟酰胺 核糖苷(NR)--一种NAD+前体--增强物理 小鼠的活动和线粒体健康。此外，天然橡胶 最近在人体临床试验中被证明是安全的 促进NAD+，但对人体体能和肌肉生理学的好处是 未知。因此，本项目的目标是建立一项双盲随机对照试验，以 评价NR对大鼠功能、肌肉功能和结构及mRNA信号转导的影响 健康的老年人。为了实现这一目标，这项研究将调查健康的老年人 65-85岁，接受NR或安慰剂治疗，为期3个月。参与者将接受测试 了解每个时间点的虚弱程度、步态速度和肌肉力量。此外，肌肉活组织检查和血清 将收集以评估肌肉纤维组织学、线粒体生物量和活性的变化，以及 信使核糖核酸。这个项目将提供更多关于NR补充剂作为一种治疗方法的深入了解 延缓虚弱并在衰老过程中保持韧性的策略。 HIIT提高物理性能 并在老化过程中减少虚弱。

Impacts of nicotinamide riboside on functional capacity and muscle physiology in older veterans Frailty is increasingly seen within the aging population and is driven largely by musculoskeletal declines. Nearly 9 million veterans are now 65 years of age or older with impairments in functional capacity, reduction in quality of life, and an increase in the use of health care services and associated costs. An estimated 45-50% of those over the age of 85 are frail, which could represent well over 1 million veterans. Aging, which significantly contributes to frailty, is highly correlated with reduced levels of nicotinamide adenine dinucleotide (NAD+), an essential mediator in mitochondrial function. Restoration of cellular NAD+ levels is gaining support as a therapeutic strategy to maintain and even enhance functional capacity during aging. Nicotinamide riboside (NR) - an NAD+ precursor - enhances physical activity and mitochondrial health in mice. Furthermore, NR was recently shown to be safe in human clinical trials for boosting NAD+, yet the benefits for human physical performance and muscle physiology are unknown. Therefore, the goal of this project is to establish a double-blind randomized control trial to assess the impacts of NR on functional capacity, muscle function and structure, and mRNA signaling in healthy older adults. Towards this goal, this study will investigate healthy older individuals between the ages of 65-85 who will receive NR or a placebo for a period of 3 months. Participants will be tested for frailty, gait speed, and muscle strength at each time point. Additionally, muscle biopsies and serum will be collected to assess changes in muscle fiber histology, mitochondrial biomass and activity, and mRNA profiles. This project will provide greater insight into NR supplementation as a therapeutic strategy to stave off frailty and maintain resilience during aging. HIIT enhances physical performance and reduces frailty during aging.