Impacts of nicotinamide riboside on functional capacity and muscle physiology in older Veterans

烟酰胺核苷对老年退伍军人功能能力和肌肉生理的影响 在老年人中， 这主要是由于肌肉骨骼的下降。 现在有近900万退伍军人年龄在65岁或以上 功能能力受损，质量下降 增加了对保健服务的使用， 相关费用。据估计，45-50%的年龄在 其中85人身体虚弱，这可能代表着超过100万人 老兵衰老，这大大有助于脆弱，是 与烟酰胺水平降低高度相关 腺嘌呤二核苷酸（NAD+）是一种重要的介体， 线粒体功能细胞NAD+水平的恢复是 获得支持作为一种治疗策略， 甚至在衰老过程中增强功能能力。烟酰胺 核苷（NR）-一种NAD+前体-增强了身体 活性和线粒体健康。此外，NR 最近在人体临床试验中被证明是安全的， 提高NAD+，但对人体体能和肌肉生理的好处是 未知因此，本项目的目标是建立一个双盲随机对照试验， 评估NR对功能能力、肌肉功能和结构以及mRNA信号传导的影响， 健康的老年人。为了实现这一目标，这项研究将调查健康的老年人之间， 年龄在65-85岁之间，将接受NR或安慰剂治疗3个月。参与者将接受测试 在每个时间点的虚弱、步态速度和肌肉力量。此外，肌肉活检和血清 将收集以评估肌纤维组织学、线粒体生物量和活性的变化， mRNA图谱。该项目将提供更深入的了解NR补充剂作为一种治疗 在衰老过程中避免脆弱和保持弹性的策略。 HIIT增强体能 并减少衰老过程中的脆弱性。

Impacts of nicotinamide riboside on functional capacity and muscle physiology in older veterans Frailty is increasingly seen within the aging population and is driven largely by musculoskeletal declines. Nearly 9 million veterans are now 65 years of age or older with impairments in functional capacity, reduction in quality of life, and an increase in the use of health care services and associated costs. An estimated 45-50% of those over the age of 85 are frail, which could represent well over 1 million veterans. Aging, which significantly contributes to frailty, is highly correlated with reduced levels of nicotinamide adenine dinucleotide (NAD+), an essential mediator in mitochondrial function. Restoration of cellular NAD+ levels is gaining support as a therapeutic strategy to maintain and even enhance functional capacity during aging. Nicotinamide riboside (NR) - an NAD+ precursor - enhances physical activity and mitochondrial health in mice. Furthermore, NR was recently shown to be safe in human clinical trials for boosting NAD+, yet the benefits for human physical performance and muscle physiology are unknown. Therefore, the goal of this project is to establish a double-blind randomized control trial to assess the impacts of NR on functional capacity, muscle function and structure, and mRNA signaling in healthy older adults. Towards this goal, this study will investigate healthy older individuals between the ages of 65-85 who will receive NR or a placebo for a period of 3 months. Participants will be tested for frailty, gait speed, and muscle strength at each time point. Additionally, muscle biopsies and serum will be collected to assess changes in muscle fiber histology, mitochondrial biomass and activity, and mRNA profiles. This project will provide greater insight into NR supplementation as a therapeutic strategy to stave off frailty and maintain resilience during aging. HIIT enhances physical performance and reduces frailty during aging.