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Impacts of nicotinamide riboside on functional capacity and muscle physiology in older Veterans

烟酰胺核苷对老年退伍军人功能能力和肌肉生理学的影响

基本信息

批准号：
10642830
负责人：
KENNETH LADD SELDEEN
金额：
--
依托单位：
KANSAS CITY VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10642830
关键词：
Activities of Daily Living Affect Age Age Years Aging Animals Area Biomass Biopsy Cardiovascular system Cell Respiration Cell physiology Clinical Clinical Trials Cognition Communities Coupled Data Dementia Double-Blind Method Elderly Exclusion Exercise Exhibits Female Fiber Funding Gait speed Genus Hippocampus Goals Hand Strength Health Healthcare Histologic Histology Hospitalization Human Impairment Individual Intramuscular Link Mediator Messenger RNA Mission Mitochondria Morphology Mus Muscle Muscle Fibers Muscle Mitochondria Muscle function Muscular Atrophy Musculoskeletal NADH Nicotinamide adenine dinucleotide Nutritional Oxygen Participant Pathway Analysis Performance Persons Physical Function Physical Performance Physical activity Physiological Placebos Publishing Publishing Peer Reviews Quality of life Randomized, Controlled Trials Reporting Research Research Design Resources Risk Safety Serum Signal Pathway Signal Transduction Skeletal Muscle Supplementation Syndrome Telephone Testing Therapeutic Time VO2max Veterans Walking Western Blotting Woman Work actigraphy aging population biceps brachii muscle cofactor comorbidity cost differential expression disability risk extracellular fall risk frailty health care service utilization healthspan human very old age (85+)improved innovation insight men mortality muscle form muscle physiology muscle strength muscular structure nicotinamide riboside supplementation nicotinamide-beta-riboside novel preclinical study quadriceps muscle recruit resilience response restoration sarcopenia sex stressor study population transcriptome sequencing treadmill uptake vastus lateralis

项目摘要

Impacts of nicotinamide riboside on functional capacity and muscle physiology in older veterans Frailty is increasingly seen within the aging population and is driven largely by musculoskeletal declines. Nearly 9 million veterans are now 65 years of age or older with impairments in functional capacity, reduction in quality of life, and an increase in the use of health care services and associated costs. An estimated 45-50% of those over the age of 85 are frail, which could represent well over 1 million veterans. Aging, which significantly contributes to frailty, is highly correlated with reduced levels of nicotinamide adenine dinucleotide (NAD+), an essential mediator in mitochondrial function. Restoration of cellular NAD+ levels is gaining support as a therapeutic strategy to maintain and even enhance functional capacity during aging. Nicotinamide riboside (NR) - an NAD+ precursor - enhances physical activity and mitochondrial health in mice. Furthermore, NR was recently shown to be safe in human clinical trials for boosting NAD+, yet the benefits for human physical performance and muscle physiology are unknown. Therefore, the goal of this project is to establish a double-blind randomized control trial to assess the impacts of NR on functional capacity, muscle function and structure, and mRNA signaling in healthy older adults. Towards this goal, this study will investigate healthy older individuals between the ages of 65-85 who will receive NR or a placebo for a period of 3 months. Participants will be tested for frailty, gait speed, and muscle strength at each time point. Additionally, muscle biopsies and serum will be collected to assess changes in muscle fiber histology, mitochondrial biomass and activity, and mRNA profiles. This project will provide greater insight into NR supplementation as a therapeutic strategy to stave off frailty and maintain resilience during aging. HIIT enhances physical performance and reduces frailty during aging.

烟酰胺核苷对老年退伍军人功能和肌肉生理的影响