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Improving Glycemic Control with Electrical Stimulation in Mexican-Americans

通过电刺激改善墨西哥裔美国人的血糖控制

基本信息

批准号：
10421136
负责人：
Sudip Bajpeyi
金额：
$ 30.6万
依托单位：
UNIVERSITY OF TEXAS EL PASO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10421136
关键词：
5&apos -AMP-activated protein kinase Acute Adherence Adoption Adult Affect Basal metabolic rate Blood Body Composition Body measure procedure Cell Culture Techniques Centers for Disease Control and Prevention (U.S.)Cessation of life Chronic Clinical Trials Contracts Data Defect Diagnosis Dual-Energy X-Ray Absorptiometry Effectiveness Electric Stimulation Energy Metabolism Epidemic Exercise Fatty acid glycerol esters Foundations General Population Glucose Transporter Goals Guidelines Health Health Care Costs Healthcare Hour Human Immobilization Impairment In Vitro Indirect Calorimetry Individual Insulin Resistance Intervention Knowledge Limb structure Lipids Literature Longitudinal Studies Measures Metabolic Metabolic Diseases Methods Mexican Americans Mexico Minority Groups Mitochondria Modeling Muscle Cells Muscle Contraction Muscle Fibers Muscular Atrophy Musculoskeletal Pain Non-Insulin-Dependent Diabetes Mellitus Not Hispanic or Latino OGTT Obesity Overweight Peripheral Nervous System Diseases Physical activity Population Populations at Risk Prevalence Prevention Preventive treatment Protocols documentation Randomized Randomized Controlled Trials Rehabilitation therapy Research Risk Risk Factors Role Skeletal Muscle Strenuous Exercise Testing Texas United States National Center for Health Statistics base blood lipid cardiovascular risk factor clinical practice cost effective effectiveness testing exercise intensity glucose monitor glycemic control human subject improved innovation insulin sensitivity lipid metabolism longitudinal human study metabolic profile minority health muscle form muscle strength neuromuscular neuromuscular function neuromuscular stimulation novel obese person oxidation physical inactivity prevent respiratory sedentary sedentary lifestyle study population vigorous intensity

项目摘要

PROJECT ABSTRACT/SUMMARY Over the few decades, metabolic diseases such as obesity, insulin resistance, and type 2 diabetes have risen to epidemic proportions, particularly among Mexican-Americans, and are leading to a high health care costs nationwide. Meanwhile, adherence to physical activity to prevent these metabolic diseases has declined. A majority (80%) of adults in the US do not meet the ACSM-recommended 150 minutes of moderate or 75 minutes of vigorous exercise per week. Mexican-Americans have greater prevalence of physical inactivity compared to the general population. Therefore, it is critical to develop additional strategies to increase adoption and adherence to physical activity in this at-risk population. The long-term goal of our research is to explore effective strategies to improve glycemic control, insulin sensitivity and metabolic health in sedentary humans, particularly those who are unable to exercise or are at risk for developing T2D. Neuromuscular Electrical Stimulation (e-stim) is a practical, non-invasive, cost-effective and innovative method to promote an alternative mode of muscle contraction among individuals who are less likely to engage in conventional physical activity. Over the past decade, we have developed and established in vitro exercise models using e- stim to contract human primary muscle cells (myotubes) to study the mechanisms by which muscle contraction positively influences insulin sensitivity and lipid metabolism. Although e-stim is widely used in rehabilitation settings to prevent muscle loss, there is a gap in the literature defining the effectiveness of e-stim to improve insulin sensitivity and metabolic health. Our preliminary data and existing literature indicate a promising application of e-stim to improve glycemic control, insulin sensitivity and metabolic health in an at-risk sedentary, overweight or obese population. Based on our preliminary data, we propose to perform a comprehensive randomized controlled trial (n=30) to determine the effects of 8 weeks of e-stim, on glycemic control as measured by continuous glucose monitoring, insulin sensitivity by oral glucose tolerance test, energy metabolism (resting metabolic rate, substrate utilization, blood lipid and metabolic profile), body composition, and muscle strength in an at-risk, sedentary, overweight/obese, Mexican-American population. We hypothesize that e-stim will improve 24 hour. glycemic control, increase insulin sensitivity, and improve overall metabolic health in this population. This study will allow us to evaluate the feasibility of using e-stim as a novel preventative treatment for insulin resistance and metabolic diseases in a sedentary population and will lay the foundation for a larger clinical trial with potential to impact clinical practice to prevent and treat type 2 diabetes.

项目摘要/总结