Maternal Omics to Maximize Immunity

母体组学最大化免疫力

• 批准号: 10420106
• 负责人: MICHAL Aviva ELOVITZ
• 金额: $ 235.4万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-19 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10420106
• 关键词: 2019-nCoV; Allografting; Atlases; Autoimmune; Birth; COVID-19 pandemic; COVID-19 severity; Clinical; Communicable Diseases; Communities; Custom; Data; Data Analyses; Data Set; Development; Disease; Ensure; Etiology; Fertility; Fertilization; Fetal health; Fetus; Foundations; Genetic Transcription; Global Awareness; Growth; Human; Immune; Immune Tolerance; Immune response; Immune system; Immunity; Immunologics; Immunology; Individual; Infection; Inflammation; Intervention; Invaded; Knowledge; Lactation; Lead; Maternal Health; Maternal-fetal medicine; Maternally-Acquired Immunity; Metagenomics; Mothers; Nature; Newborn Infant; Organ; Phase; Play; Population; Pregnancy; Pregnant Women; Process; Proteomics; Race; Recording of previous events; Research Personnel; Role; Secondary Immunization; Shapes; System; Systems Biology; Technology; Time; Tissues; Vaccination; Vaccines; Work; cell type; data management; density; fetal; health of the mother; implantation; improved; in vivo; maternal vaccination; metabolomics; multidisciplinary; multiple omics; neonatal health; novel; novel therapeutics; novel vaccines; pathogen; predictive marker; pregnancy health; pregnant; prophylactic; rational design; success; targeted treatment; tool; vaccination strategy; vaccine platform; vaccine trial; vaccine-induced immunity; vaccinology

Overall: Summary From the moment of fertilization to birth, the maternal immune system evolves, adapts, and supports the growth of a fetal allograft that ultimately perpetuates the human race. Immunological changes throughout a pregnancy play a key deterministic role in the success of the pregnancy. While pregnancy was historically regarded as a simple shift towards tolerance, emerging immunological data point to remarkable dynamic changes during pregnancy. The pregnancy immunome must protect the fetus from a maternal attack while at the same time it must afford the maternal-fetal dyad protection from invading pathogens. The health of the mother and the fetus requires that these two opposing immunological tasks work in concert. Thus collectively, pregnancy marks a whirlwind of immune adaptations that render the pregnant immune system a truly unique immunologic marvel. Despite our growing appreciation for these highly controlled dynamic shifts, the precise mechanisms that lead to optimal pregnancy health, profoundly impacting both mother and fetus, are incompletely understood, delaying the development of targeted therapies for this population. Capitalizing on this unique moment in vaccine history, with the introduction of several novel-vaccine platforms for SARS-CoV-2, the consortium will build a Pregnancy Immune Atlas via the application of high-density immunological profiling technologies to deeply and comprehensively dissect the overall changes that occur across pregnancy and how the immune system, as a collective, responds to in vivo perturbations with vaccines. Using both de novo vaccine induced immune responses and booster vaccination, the consortium will capture overall changes in the pregnant ImmunOME as well as shifts in the pregnant AdaptOME to fully capture the immunological mechanisms that govern the balanced growth of the fetus and battle of the maternal:fetal dyad against invading pathogens. Thus, together the Maternal ‘Omics to Maximize Immunity (MOMi) consortium seeks to build the foundational data to advance our knowledge of natural tolerance, fertility, shifts in immunity during pregnancy to better understand this evolutionary marvel required for the perpetuation of the human species.

总体：摘要 从受精的那一刻到出生，母体免疫系统会发展，适应和支持 胎儿同种异体移植的生长最终使人类永久存在。整个A的免疫学变化 怀孕在怀孕的成功中起关键的决定性作用。而怀孕历史上是 被认为是朝着公差的简单转变，新兴的免疫数据指向显着动态 怀孕期间的变化。怀孕疫苗必须保护胎儿在 同时，它必须负担不受入侵病原体的孕产妇二元组的保护。母亲的健康 胎儿要求这两个相对的免疫学任务共同起作用。这是总体怀孕 标志着免疫适应的旋风，使怀孕的免疫系统成为真正独特的免疫学 奇迹。尽管我们对这些高度控制的动态转变越来越欣赏，但具有确切机制 导致最佳妊娠健康，对母亲和胎儿产生深远影响，尚不完全理解， 延迟了该人群的靶向疗法的发展。利用疫苗的独特时刻 历史，随着为SARS-COV-2引入多个新型疫苗平台，该财团将建立一个 通过将高密度免疫分析技术应用于深层和 全面阐述怀孕期间发生的总体变化以及免疫系统如何作为 集体，对疫苗的体内扰动做出反应。使用两种从头疫苗诱导的免疫 反应和加强疫苗接种，财团将捕获怀孕免疫组的总体变化 以及怀孕适应体的转变，以充分捕获控制平衡的免疫机制 胎儿的生长和母体战斗：胎儿二元对入侵病原体。那在一起 ‘最大化免疫力（MOMI）财团的OMIC旨在建立基础数据以推动我们的 了解自然耐受性，生育能力，怀孕期间免疫的转变，以更好地了解这种进化 持续人类所需的奇迹。