Maternal Omics to Maximize Immunity
母体组学最大化免疫力
基本信息
- 批准号:10420106
- 负责人:
- 金额:$ 235.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-19 至 2027-03-31
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAllograftingAtlasesAutoimmuneBirthCOVID-19 pandemicCOVID-19 severityClinicalCommunicable DiseasesCommunitiesCustomDataData AnalysesData SetDevelopmentDiseaseEnsureEtiologyFertilityFertilizationFetal healthFetusFoundationsGenetic TranscriptionGlobal AwarenessGrowthHumanImmuneImmune ToleranceImmune responseImmune systemImmunityImmunologicsImmunologyIndividualInfectionInflammationInterventionInvadedKnowledgeLactationLeadMaternal HealthMaternal-fetal medicineMaternally-Acquired ImmunityMetagenomicsMothersNatureNewborn InfantOrganPhasePlayPopulationPregnancyPregnant WomenProcessProteomicsRaceRecording of previous eventsResearch PersonnelRoleSecondary ImmunizationShapesSystemSystems BiologyTechnologyTimeTissuesVaccinationVaccinesWorkcell typedata managementdensityfetalhealth of the motherimplantationimprovedin vivomaternal vaccinationmetabolomicsmultidisciplinarymultiple omicsneonatal healthnovelnovel therapeuticsnovel vaccinespathogenpredictive markerpregnancy healthpregnantprophylacticrational designsuccesstargeted treatmenttoolvaccination strategyvaccine platformvaccine trialvaccine-induced immunityvaccinology
项目摘要
Overall: Summary
From the moment of fertilization to birth, the maternal immune system evolves, adapts, and supports the
growth of a fetal allograft that ultimately perpetuates the human race. Immunological changes throughout a
pregnancy play a key deterministic role in the success of the pregnancy. While pregnancy was historically
regarded as a simple shift towards tolerance, emerging immunological data point to remarkable dynamic
changes during pregnancy. The pregnancy immunome must protect the fetus from a maternal attack while at
the same time it must afford the maternal-fetal dyad protection from invading pathogens. The health of the mother
and the fetus requires that these two opposing immunological tasks work in concert. Thus collectively, pregnancy
marks a whirlwind of immune adaptations that render the pregnant immune system a truly unique immunologic
marvel. Despite our growing appreciation for these highly controlled dynamic shifts, the precise mechanisms that
lead to optimal pregnancy health, profoundly impacting both mother and fetus, are incompletely understood,
delaying the development of targeted therapies for this population. Capitalizing on this unique moment in vaccine
history, with the introduction of several novel-vaccine platforms for SARS-CoV-2, the consortium will build a
Pregnancy Immune Atlas via the application of high-density immunological profiling technologies to deeply and
comprehensively dissect the overall changes that occur across pregnancy and how the immune system, as a
collective, responds to in vivo perturbations with vaccines. Using both de novo vaccine induced immune
responses and booster vaccination, the consortium will capture overall changes in the pregnant ImmunOME as
well as shifts in the pregnant AdaptOME to fully capture the immunological mechanisms that govern the balanced
growth of the fetus and battle of the maternal:fetal dyad against invading pathogens. Thus, together the Maternal
‘Omics to Maximize Immunity (MOMi) consortium seeks to build the foundational data to advance our
knowledge of natural tolerance, fertility, shifts in immunity during pregnancy to better understand this evolutionary
marvel required for the perpetuation of the human species.
总体:总结
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MICHAL Aviva ELOVITZ其他文献
MICHAL Aviva ELOVITZ的其他文献
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{{ truncateString('MICHAL Aviva ELOVITZ', 18)}}的其他基金
Unraveling mechanisms by which cervicovaginal microbiota can promote or prevent cervical remodeling and preterm birth
揭示宫颈阴道微生物群促进或预防宫颈重塑和早产的机制
- 批准号:
10800388 - 财政年份:2023
- 资助金额:
$ 235.4万 - 项目类别:
Deciphering the Role of Vaginal Microbes in Preterm birth
解读阴道微生物在早产中的作用
- 批准号:
10647700 - 财政年份:2023
- 资助金额:
$ 235.4万 - 项目类别:
Deciphering the Role of Vaginal Microbes in Preterm birth
解读阴道微生物在早产中的作用
- 批准号:
10800417 - 财政年份:2023
- 资助金额:
$ 235.4万 - 项目类别:
Unraveling mechanisms by which cervicovaginal microbiota can promote or prevent cervical remodeling and preterm birth
揭示宫颈阴道微生物群促进或预防宫颈重塑和早产的机制
- 批准号:
10223393 - 财政年份:2020
- 资助金额:
$ 235.4万 - 项目类别:
Unraveling mechanisms by which cervicovaginal microbiota can promote or prevent cervical remodeling and preterm birth
揭示宫颈阴道微生物群促进或预防宫颈重塑和早产的机制
- 批准号:
9886482 - 财政年份:2020
- 资助金额:
$ 235.4万 - 项目类别:
Unraveling mechanisms by which cervicovaginal microbiota can promote or prevent cervical remodeling and preterm birth
揭示宫颈阴道微生物群促进或预防宫颈重塑和早产的机制
- 批准号:
10397425 - 财政年份:2020
- 资助金额:
$ 235.4万 - 项目类别:
Deciphering the Role of Vaginal Microbes in Preterm birth
解读阴道微生物在早产中的作用
- 批准号:
10026955 - 财政年份:2020
- 资助金额:
$ 235.4万 - 项目类别:
Deciphering the Role of Vaginal Microbes in Preterm birth
解读阴道微生物在早产中的作用
- 批准号:
10432076 - 财政年份:2020
- 资助金额:
$ 235.4万 - 项目类别:
Deciphering the Role of Vaginal Microbes in Preterm birth
解读阴道微生物在早产中的作用
- 批准号:
10249230 - 财政年份:2020
- 资助金额:
$ 235.4万 - 项目类别:
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