Maternal Omics to Maximize Immunity

母体组学最大化免疫力

• 批准号: 10420106
• 负责人: MICHAL Aviva ELOVITZ
• 金额: $ 235.4万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-19 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10420106
• 关键词: 2019-nCoV; Allografting; Atlases; Autoimmune; Birth; COVID-19 pandemic; COVID-19 severity; Clinical; Communicable Diseases; Communities; Custom; Data; Data Analyses; Data Set; Development; Disease; Ensure; Etiology; Fertility; Fertilization; Fetal health; Fetus; Foundations; Genetic Transcription; Global Awareness; Growth; Human; Immune; Immune Tolerance; Immune response; Immune system; Immunity; Immunologics; Immunology; Individual; Infection; Inflammation; Intervention; Invaded; Knowledge; Lactation; Lead; Maternal Health; Maternal-fetal medicine; Maternally-Acquired Immunity; Metagenomics; Mothers; Nature; Newborn Infant; Organ; Phase; Play; Population; Pregnancy; Pregnant Women; Process; Proteomics; Race; Recording of previous events; Research Personnel; Role; Secondary Immunization; Shapes; System; Systems Biology; Technology; Time; Tissues; Vaccination; Vaccines; Work; cell type; data management; density; fetal; health of the mother; implantation; improved; in vivo; maternal vaccination; metabolomics; multidisciplinary; multiple omics; neonatal health; novel; novel therapeutics; novel vaccines; pathogen; predictive marker; pregnancy health; pregnant; prophylactic; rational design; success; targeted treatment; tool; vaccination strategy; vaccine platform; vaccine trial; vaccine-induced immunity; vaccinology

Overall: Summary From the moment of fertilization to birth, the maternal immune system evolves, adapts, and supports the growth of a fetal allograft that ultimately perpetuates the human race. Immunological changes throughout a pregnancy play a key deterministic role in the success of the pregnancy. While pregnancy was historically regarded as a simple shift towards tolerance, emerging immunological data point to remarkable dynamic changes during pregnancy. The pregnancy immunome must protect the fetus from a maternal attack while at the same time it must afford the maternal-fetal dyad protection from invading pathogens. The health of the mother and the fetus requires that these two opposing immunological tasks work in concert. Thus collectively, pregnancy marks a whirlwind of immune adaptations that render the pregnant immune system a truly unique immunologic marvel. Despite our growing appreciation for these highly controlled dynamic shifts, the precise mechanisms that lead to optimal pregnancy health, profoundly impacting both mother and fetus, are incompletely understood, delaying the development of targeted therapies for this population. Capitalizing on this unique moment in vaccine history, with the introduction of several novel-vaccine platforms for SARS-CoV-2, the consortium will build a Pregnancy Immune Atlas via the application of high-density immunological profiling technologies to deeply and comprehensively dissect the overall changes that occur across pregnancy and how the immune system, as a collective, responds to in vivo perturbations with vaccines. Using both de novo vaccine induced immune responses and booster vaccination, the consortium will capture overall changes in the pregnant ImmunOME as well as shifts in the pregnant AdaptOME to fully capture the immunological mechanisms that govern the balanced growth of the fetus and battle of the maternal:fetal dyad against invading pathogens. Thus, together the Maternal ‘Omics to Maximize Immunity (MOMi) consortium seeks to build the foundational data to advance our knowledge of natural tolerance, fertility, shifts in immunity during pregnancy to better understand this evolutionary marvel required for the perpetuation of the human species.

总体情况：摘要 从受精的那一刻到出生，母体免疫系统进化、适应并支持 胎儿同种异体移植的生长，最终使人类永生。整个生命周期的免疫学变化 妊娠对妊娠的成功起着关键的决定性作用。虽然怀孕在历史上是 新出现的免疫学数据被视为向耐受性的简单转变，表明了显著的动态 怀孕期间的变化。怀孕免疫体必须保护胎儿免受母体攻击。 与此同时，它必须提供母婴二体保护，使其免受入侵病原体的侵袭。母亲的健康 胎儿需要这两个相反的免疫学任务协同工作。因此，总体而言，怀孕 标志着免疫适应的旋风，使怀孕的免疫系统成为真正独特的免疫学 漫威。尽管我们越来越欣赏这些高度受控的动态变化，但 导致最佳的怀孕健康，对母亲和胎儿都有深远的影响，还没有完全被理解， 推迟了针对这一人群的靶向治疗的开发。利用疫苗领域的这一独特时刻 历史上，随着几个针对SARS-CoV-2的新型疫苗平台的推出，该财团将建立一个 妊娠免疫图谱通过应用高密度免疫图谱技术深入和 全面剖析怀孕期间发生的整体变化，以及免疫系统是如何 集体，用疫苗对体内的扰动做出反应。使用两种新疫苗诱导免疫 反应和加强疫苗接种，该联盟将捕捉怀孕免疫组的整体变化，如 以及妊娠适应的变化，以充分捕捉支配平衡的免疫机制 胎儿的成长和母体的战斗：胎儿与入侵的病原体的斗争。因此，在一起，母亲 ‘Omics to最大化免疫力(MOMI)联盟寻求建立基础数据来推进我们的 了解自然耐受性、生育能力、孕期免疫变化，以更好地理解这一进化过程 人类物种永垂不朽所需要的奇迹。