Maternal Omics to Maximize Immunity

母体组学最大化免疫力

基本信息

项目摘要

Overall: Summary From the moment of fertilization to birth, the maternal immune system evolves, adapts, and supports the growth of a fetal allograft that ultimately perpetuates the human race. Immunological changes throughout a pregnancy play a key deterministic role in the success of the pregnancy. While pregnancy was historically regarded as a simple shift towards tolerance, emerging immunological data point to remarkable dynamic changes during pregnancy. The pregnancy immunome must protect the fetus from a maternal attack while at the same time it must afford the maternal-fetal dyad protection from invading pathogens. The health of the mother and the fetus requires that these two opposing immunological tasks work in concert. Thus collectively, pregnancy marks a whirlwind of immune adaptations that render the pregnant immune system a truly unique immunologic marvel. Despite our growing appreciation for these highly controlled dynamic shifts, the precise mechanisms that lead to optimal pregnancy health, profoundly impacting both mother and fetus, are incompletely understood, delaying the development of targeted therapies for this population. Capitalizing on this unique moment in vaccine history, with the introduction of several novel-vaccine platforms for SARS-CoV-2, the consortium will build a Pregnancy Immune Atlas via the application of high-density immunological profiling technologies to deeply and comprehensively dissect the overall changes that occur across pregnancy and how the immune system, as a collective, responds to in vivo perturbations with vaccines. Using both de novo vaccine induced immune responses and booster vaccination, the consortium will capture overall changes in the pregnant ImmunOME as well as shifts in the pregnant AdaptOME to fully capture the immunological mechanisms that govern the balanced growth of the fetus and battle of the maternal:fetal dyad against invading pathogens. Thus, together the Maternal ‘Omics to Maximize Immunity (MOMi) consortium seeks to build the foundational data to advance our knowledge of natural tolerance, fertility, shifts in immunity during pregnancy to better understand this evolutionary marvel required for the perpetuation of the human species.
总体:总结

项目成果

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MICHAL Aviva ELOVITZ其他文献

MICHAL Aviva ELOVITZ的其他文献

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{{ truncateString('MICHAL Aviva ELOVITZ', 18)}}的其他基金

Unraveling mechanisms by which cervicovaginal microbiota can promote or prevent cervical remodeling and preterm birth
揭示宫颈阴道微生物群促进或预防宫颈重塑和早产的机制
  • 批准号:
    10800388
  • 财政年份:
    2023
  • 资助金额:
    $ 235.4万
  • 项目类别:
Deciphering the Role of Vaginal Microbes in Preterm birth
解读阴道微生物在早产中的作用
  • 批准号:
    10647700
  • 财政年份:
    2023
  • 资助金额:
    $ 235.4万
  • 项目类别:
Deciphering the Role of Vaginal Microbes in Preterm birth
解读阴道微生物在早产中的作用
  • 批准号:
    10800417
  • 财政年份:
    2023
  • 资助金额:
    $ 235.4万
  • 项目类别:
Maternal Omics to Maximize Immunity
母体组学最大化免疫力
  • 批准号:
    10611519
  • 财政年份:
    2022
  • 资助金额:
    $ 235.4万
  • 项目类别:
Unraveling mechanisms by which cervicovaginal microbiota can promote or prevent cervical remodeling and preterm birth
揭示宫颈阴道微生物群促进或预防宫颈重塑和早产的机制
  • 批准号:
    10223393
  • 财政年份:
    2020
  • 资助金额:
    $ 235.4万
  • 项目类别:
Unraveling mechanisms by which cervicovaginal microbiota can promote or prevent cervical remodeling and preterm birth
揭示宫颈阴道微生物群促进或预防宫颈重塑和早产的机制
  • 批准号:
    9886482
  • 财政年份:
    2020
  • 资助金额:
    $ 235.4万
  • 项目类别:
Unraveling mechanisms by which cervicovaginal microbiota can promote or prevent cervical remodeling and preterm birth
揭示宫颈阴道微生物群促进或预防宫颈重塑和早产的机制
  • 批准号:
    10397425
  • 财政年份:
    2020
  • 资助金额:
    $ 235.4万
  • 项目类别:
Deciphering the Role of Vaginal Microbes in Preterm birth
解读阴道微生物在早产中的作用
  • 批准号:
    10026955
  • 财政年份:
    2020
  • 资助金额:
    $ 235.4万
  • 项目类别:
Deciphering the Role of Vaginal Microbes in Preterm birth
解读阴道微生物在早产中的作用
  • 批准号:
    10432076
  • 财政年份:
    2020
  • 资助金额:
    $ 235.4万
  • 项目类别:
Deciphering the Role of Vaginal Microbes in Preterm birth
解读阴道微生物在早产中的作用
  • 批准号:
    10249230
  • 财政年份:
    2020
  • 资助金额:
    $ 235.4万
  • 项目类别:

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新型同种异体骨软骨移植联合生长因子-胶原蛋白结合域融合技术的建立
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  • 批准号:
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  • 财政年份:
    2012
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白血病同种异体移植
  • 批准号:
    8260361
  • 财政年份:
    2011
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    $ 235.4万
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Composite Allografting for Promoting Survival of Corneal Transplants
复合同种异体移植促进角膜移植的存活
  • 批准号:
    7878675
  • 财政年份:
    2009
  • 资助金额:
    $ 235.4万
  • 项目类别:
Composite Allografting for Promoting Survival of Corneal Transplants
复合同种异体移植促进角膜移植的存活
  • 批准号:
    7677758
  • 财政年份:
    2009
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    $ 235.4万
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Augmenting Antitumor Immunity after Allografting
增强同种异体移植后的抗肿瘤免疫力
  • 批准号:
    7466112
  • 财政年份:
    2008
  • 资助金额:
    $ 235.4万
  • 项目类别:
Augmenting Antitumor Immunity after Allografting
增强同种异体移植后的抗肿瘤免疫力
  • 批准号:
    8010394
  • 财政年份:
    2008
  • 资助金额:
    $ 235.4万
  • 项目类别:
Augmenting Antitumor Immunity after Allografting
增强同种异体移植后的抗肿瘤免疫力
  • 批准号:
    8208131
  • 财政年份:
    2008
  • 资助金额:
    $ 235.4万
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Augmenting Antitumor Immunity after Allografting
增强同种异体移植后的抗肿瘤免疫力
  • 批准号:
    7575273
  • 财政年份:
    2008
  • 资助金额:
    $ 235.4万
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Augmenting Antitumor Immunity after Allografting
增强同种异体移植后的抗肿瘤免疫力
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    7765518
  • 财政年份:
    2008
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    $ 235.4万
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