Maternal Omics to Maximize Immunity

母体组学最大化免疫力

基本信息

项目摘要

Overall: Summary From the moment of fertilization to birth, the maternal immune system evolves, adapts, and supports the growth of a fetal allograft that ultimately perpetuates the human race. Immunological changes throughout a pregnancy play a key deterministic role in the success of the pregnancy. While pregnancy was historically regarded as a simple shift towards tolerance, emerging immunological data point to remarkable dynamic changes during pregnancy. The pregnancy immunome must protect the fetus from a maternal attack while at the same time it must afford the maternal-fetal dyad protection from invading pathogens. The health of the mother and the fetus requires that these two opposing immunological tasks work in concert. Thus collectively, pregnancy marks a whirlwind of immune adaptations that render the pregnant immune system a truly unique immunologic marvel. Despite our growing appreciation for these highly controlled dynamic shifts, the precise mechanisms that lead to optimal pregnancy health, profoundly impacting both mother and fetus, are incompletely understood, delaying the development of targeted therapies for this population. Capitalizing on this unique moment in vaccine history, with the introduction of several novel-vaccine platforms for SARS-CoV-2, the consortium will build a Pregnancy Immune Atlas via the application of high-density immunological profiling technologies to deeply and comprehensively dissect the overall changes that occur across pregnancy and how the immune system, as a collective, responds to in vivo perturbations with vaccines. Using both de novo vaccine induced immune responses and booster vaccination, the consortium will capture overall changes in the pregnant ImmunOME as well as shifts in the pregnant AdaptOME to fully capture the immunological mechanisms that govern the balanced growth of the fetus and battle of the maternal:fetal dyad against invading pathogens. Thus, together the Maternal ‘Omics to Maximize Immunity (MOMi) consortium seeks to build the foundational data to advance our knowledge of natural tolerance, fertility, shifts in immunity during pregnancy to better understand this evolutionary marvel required for the perpetuation of the human species.
总体情况:摘要 从受精的那一刻到出生,母体免疫系统进化、适应并支持 胎儿同种异体移植的生长,最终使人类永生。整个生命周期的免疫学变化 妊娠对妊娠的成功起着关键的决定性作用。虽然怀孕在历史上是 新出现的免疫学数据被视为向耐受性的简单转变,表明了显著的动态 怀孕期间的变化。怀孕免疫体必须保护胎儿免受母体攻击。 与此同时,它必须提供母婴二体保护,使其免受入侵病原体的侵袭。母亲的健康 胎儿需要这两个相反的免疫学任务协同工作。因此,总体而言,怀孕 标志着免疫适应的旋风,使怀孕的免疫系统成为真正独特的免疫学 漫威。尽管我们越来越欣赏这些高度受控的动态变化,但 导致最佳的怀孕健康,对母亲和胎儿都有深远的影响,还没有完全被理解, 推迟了针对这一人群的靶向治疗的开发。利用疫苗领域的这一独特时刻 历史上,随着几个针对SARS-CoV-2的新型疫苗平台的推出,该财团将建立一个 妊娠免疫图谱通过应用高密度免疫图谱技术深入和 全面剖析怀孕期间发生的整体变化,以及免疫系统是如何 集体,用疫苗对体内的扰动做出反应。使用两种新疫苗诱导免疫 反应和加强疫苗接种,该联盟将捕捉怀孕免疫组的整体变化,如 以及妊娠适应的变化,以充分捕捉支配平衡的免疫机制 胎儿的成长和母体的战斗:胎儿与入侵的病原体的斗争。因此,在一起,母亲 ‘Omics to最大化免疫力(MOMI)联盟寻求建立基础数据来推进我们的 了解自然耐受性、生育能力、孕期免疫变化,以更好地理解这一进化过程 人类物种永垂不朽所需要的奇迹。

项目成果

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MICHAL Aviva ELOVITZ其他文献

MICHAL Aviva ELOVITZ的其他文献

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{{ truncateString('MICHAL Aviva ELOVITZ', 18)}}的其他基金

Unraveling mechanisms by which cervicovaginal microbiota can promote or prevent cervical remodeling and preterm birth
揭示宫颈阴道微生物群促进或预防宫颈重塑和早产的机制
  • 批准号:
    10800388
  • 财政年份:
    2023
  • 资助金额:
    $ 235.4万
  • 项目类别:
Deciphering the Role of Vaginal Microbes in Preterm birth
解读阴道微生物在早产中的作用
  • 批准号:
    10647700
  • 财政年份:
    2023
  • 资助金额:
    $ 235.4万
  • 项目类别:
Deciphering the Role of Vaginal Microbes in Preterm birth
解读阴道微生物在早产中的作用
  • 批准号:
    10800417
  • 财政年份:
    2023
  • 资助金额:
    $ 235.4万
  • 项目类别:
Maternal Omics to Maximize Immunity
母体组学最大化免疫力
  • 批准号:
    10611519
  • 财政年份:
    2022
  • 资助金额:
    $ 235.4万
  • 项目类别:
Unraveling mechanisms by which cervicovaginal microbiota can promote or prevent cervical remodeling and preterm birth
揭示宫颈阴道微生物群促进或预防宫颈重塑和早产的机制
  • 批准号:
    10223393
  • 财政年份:
    2020
  • 资助金额:
    $ 235.4万
  • 项目类别:
Unraveling mechanisms by which cervicovaginal microbiota can promote or prevent cervical remodeling and preterm birth
揭示宫颈阴道微生物群促进或预防宫颈重塑和早产的机制
  • 批准号:
    9886482
  • 财政年份:
    2020
  • 资助金额:
    $ 235.4万
  • 项目类别:
Unraveling mechanisms by which cervicovaginal microbiota can promote or prevent cervical remodeling and preterm birth
揭示宫颈阴道微生物群促进或预防宫颈重塑和早产的机制
  • 批准号:
    10397425
  • 财政年份:
    2020
  • 资助金额:
    $ 235.4万
  • 项目类别:
Deciphering the Role of Vaginal Microbes in Preterm birth
解读阴道微生物在早产中的作用
  • 批准号:
    10026955
  • 财政年份:
    2020
  • 资助金额:
    $ 235.4万
  • 项目类别:
Deciphering the Role of Vaginal Microbes in Preterm birth
解读阴道微生物在早产中的作用
  • 批准号:
    10432076
  • 财政年份:
    2020
  • 资助金额:
    $ 235.4万
  • 项目类别:
Deciphering the Role of Vaginal Microbes in Preterm birth
解读阴道微生物在早产中的作用
  • 批准号:
    10249230
  • 财政年份:
    2020
  • 资助金额:
    $ 235.4万
  • 项目类别:

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Establishment of novel osteochondral allografting combined with growth factor- collagen-binding domain fusion technology
新型同种异体骨软骨移植联合生长因子-胶原蛋白结合域融合技术的建立
  • 批准号:
    26462277
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    2014
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Translating PTH Therapy as an Adjuvant for Structural Allografting
将 PTH 疗法转化为结构性同种异体移植的佐剂
  • 批准号:
    8344380
  • 财政年份:
    2012
  • 资助金额:
    $ 235.4万
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Allografting for Lukemia
白血病同种异体移植
  • 批准号:
    8260361
  • 财政年份:
    2011
  • 资助金额:
    $ 235.4万
  • 项目类别:
Composite Allografting for Promoting Survival of Corneal Transplants
复合同种异体移植促进角膜移植的存活
  • 批准号:
    7878675
  • 财政年份:
    2009
  • 资助金额:
    $ 235.4万
  • 项目类别:
Composite Allografting for Promoting Survival of Corneal Transplants
复合同种异体移植促进角膜移植的存活
  • 批准号:
    7677758
  • 财政年份:
    2009
  • 资助金额:
    $ 235.4万
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Augmenting Antitumor Immunity after Allografting
增强同种异体移植后的抗肿瘤免疫力
  • 批准号:
    7466112
  • 财政年份:
    2008
  • 资助金额:
    $ 235.4万
  • 项目类别:
Augmenting Antitumor Immunity after Allografting
增强同种异体移植后的抗肿瘤免疫力
  • 批准号:
    8010394
  • 财政年份:
    2008
  • 资助金额:
    $ 235.4万
  • 项目类别:
Augmenting Antitumor Immunity after Allografting
增强同种异体移植后的抗肿瘤免疫力
  • 批准号:
    8208131
  • 财政年份:
    2008
  • 资助金额:
    $ 235.4万
  • 项目类别:
Augmenting Antitumor Immunity after Allografting
增强同种异体移植后的抗肿瘤免疫力
  • 批准号:
    7575273
  • 财政年份:
    2008
  • 资助金额:
    $ 235.4万
  • 项目类别:
Augmenting Antitumor Immunity after Allografting
增强同种异体移植后的抗肿瘤免疫力
  • 批准号:
    7765518
  • 财政年份:
    2008
  • 资助金额:
    $ 235.4万
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