Interrogating the intersection between diet and ocular autoimmunity
探究饮食与眼部自身免疫之间的交叉点
基本信息
- 批准号:10419170
- 负责人:
- 金额:$ 58.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-01 至 2027-03-31
- 项目状态:未结题
- 来源:
- 关键词:AdjuvantAdoptive TransferAdverse effectsAnatomyAnti-Inflammatory AgentsAutoimmuneAutoimmune DiseasesAutoimmunityBiological AssayBlindnessBloodBrainCardiovascular systemCellsCentral Nervous System DiseasesClinical TrialsConsumptionDemyelinationsDiagnosticDietDiet HabitsDiseaseEnvironmentErythrocytesErythropoietinExperimental Autoimmune EncephalomyelitisEyeFatty AcidsFatty acid glycerol estersFlareFoodFumaratesGoalsHealthHomeostasisITGAM geneImmuneImmune ToleranceImmunohistochemistryImmunologicsIncidenceInflammationInflammatoryInterleukin-17Intestinal permeabilityIntestinesLeaky GutLife StyleLinkMeasurementMediatingMedium chain triglyceridesMetabolicMetabolic syndromeModelingMultiple SclerosisMultiple Sclerosis LesionsMusNatural ImmunityNeuromyelitis OpticaOcular PathologyOptic NerveOptic NeuritisOpticsOralOutcomePainPathogenicityPathologyPatientsPlasmaPopulationPredispositionProcessPsychophysicsRecombinantsReducing dietReporterResolutionRetinaSiteSjogren&aposs SyndromeSourceSpinal CordT-LymphocyteTestingTimeTreatment EfficacyUveitisVisionWorkadaptive immunityautoreactive T cellbasecytokinedesigndiagnostic biomarkerdietarydysbiosisempoweredexperiencegut healthgut homeostasisgut microbiomeimmunoregulationimprovedin vivoinflammatory markerinflammatory milieuketogenic dietlipidomicsmigrationmonocytemotor deficitmouse modelmultiple sclerosis patientmultiple sclerosis treatmentnerve damageneuroprotectionnovelnutritional approachoculomotorprematurepreservationpreventreconstitutionremyelinationrepairedstandard of caresystemic inflammatory responsetreatment responsevisual motor
项目摘要
5-8% of the US population suffers from at least one autoimmune disease. An upward trajectory has
occurred in the last few decades, implicating diet, lifestyle, environment, and improved diagnostics. The
contributions of diet to this increased incidence have been attributed to the excessive consumption of ultra-
processed foods that drive systemic inflammation. Just as poor dietary habits can compromise health, diseases
can potentially be treated or prevented by diets that promote and restore metabolic homeostasis. Consistent
with this notion, we have demonstrated that a well-formulated ketogenic diet (KD), containing medium chain
triglycerides as the primary source of fat, can mitigate the visual and motor deficits in a mouse model of
autoimmunity called MOG-EAE. This model reconstitutes many of the signature ocular and motor pathologies
experienced by patients with Multiple Sclerosis (MS) and Neuromyelitis Optica. The goals of this application
are: (1) to identify the immuno-modulatory mechanisms by which a well-formulated KD preserves metabolic
homeostasis, gut health, and immune tolerance, (2) to determine if a KD can serve as an adjuvant to enhance
the vision-sparing capacity of existing MS treatments and (3) to determine if the KD can repair damaged nerves
by promoting remyelination. Our leading hypothesis is that a well-formulated KD promotes immune tolerance
and neuroprotection by creating a systemic anti-inflammatory milieu. Specific Aim 1 will identify the mechanisms
linking gut integrity and plasma fatty acids to optic neuritis, a painful and often blinding inflammation of the optic
nerve experienced by MS patients. Specific Aim 2 will determine if the KD can enhance the vision-sparing
capacity of several current MS treatments. Specific Aim 3 will identify novel immunological mechanisms that
mediate the efficacy of the KD during autoimmune challenge. This work combines psychophysical
measurements of vision, a novel reporter mouse, gut permeability assays, high resolution lipidomics, adoptive
transfer assays, and blood analyses for markers of inflammation and metabolic/cardiovascular status. This work
is distinguished from previous studies by comparing the anatomic-specific effects of the KD at each of the primary
sites of MS lesions (optic nerve, spinal cord, and brain).
These studies are designed to overcome the serious adverse effects associated with current MS
treatments by empowering patients with a readily-implementable dietary strategy to prevent or reduce flare ups
of optic neuritis and other debilitating sequelae. Additionally, these findings will provide a framework to facilitate
interpreting outcomes from the numerous clinical trials currently testing the KD across a range of diseases.
5-8%的美国人患有至少一种自身免疫性疾病。向上的轨迹
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Scott M Plafker其他文献
Scott M Plafker的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Scott M Plafker', 18)}}的其他基金
Interrogating the intersection between diet and ocular autoimmunity
探究饮食与眼部自身免疫之间的交叉点
- 批准号:
10597231 - 财政年份:2022
- 资助金额:
$ 58.08万 - 项目类别:
Treatment strategies for autoimmune demyelinating optic neuritis
自身免疫性脱髓鞘性视神经炎的治疗策略
- 批准号:
9249047 - 财政年份:2016
- 资助金额:
$ 58.08万 - 项目类别:
OKHSC COBRE: THE ROLE OF THE UBIQUITIN SYSTEM IN RETINAL DEGENERATION
OKHSC COBRE:泛素系统在视网膜变性中的作用
- 批准号:
8360280 - 财政年份:2011
- 资助金额:
$ 58.08万 - 项目类别:
Control of redox regulators by the ubiquitin system
泛素系统对氧化还原调节剂的控制
- 批准号:
8727042 - 财政年份:2011
- 资助金额:
$ 58.08万 - 项目类别:
Control of redox regulators by the ubiquitin system
泛素系统对氧化还原调节剂的控制
- 批准号:
8536839 - 财政年份:2011
- 资助金额:
$ 58.08万 - 项目类别:
Control of redox regulators by the ubiquitin system
泛素系统对氧化还原调节剂的控制
- 批准号:
8106682 - 财政年份:2011
- 资助金额:
$ 58.08万 - 项目类别:
Control of redox regulators by the ubiquitin system
泛素系统对氧化还原调节剂的控制
- 批准号:
8320952 - 财政年份:2011
- 资助金额:
$ 58.08万 - 项目类别:
OKHSC COBRE: PROTECTING THE RETINA FROM OXIDATIVE STRESS
OKHSC COBRE:保护视网膜免受氧化应激
- 批准号:
8167973 - 财政年份:2010
- 资助金额:
$ 58.08万 - 项目类别:
OKHSC COBRE: UBIQUITIN IN HYPERGLYCEMIA-INDUCED MESANGIAL CELL HYPERTROPHY
OKHSC COBRE:泛素在高血糖引起的系膜细胞肥大中的作用
- 批准号:
7959775 - 财政年份:2009
- 资助金额:
$ 58.08万 - 项目类别:
OKHSC COBRE: UBIQUITIN IN HYPERGLYCEMIA-INDUCED MESANGIAL CELL HYPERTROPHY
OKHSC COBRE:泛素在高血糖引起的系膜细胞肥大中的作用
- 批准号:
7721020 - 财政年份:2008
- 资助金额:
$ 58.08万 - 项目类别:
相似海外基金
Time to ATTAC: Adoptive Transfer of T cells Against gp100+ Cells to treat LAM
ATTAC 时间:针对 gp100 细胞的 T 细胞过继转移来治疗 LAM
- 批准号:
10682121 - 财政年份:2023
- 资助金额:
$ 58.08万 - 项目类别:
Phase I clinical trial of adoptive transfer of autologous folate receptor-alpha redirected CAR T cells for ovarian cancer
自体叶酸受体-α重定向CAR T细胞过继转移治疗卵巢癌的I期临床试验
- 批准号:
10576370 - 财政年份:2022
- 资助金额:
$ 58.08万 - 项目类别:
Phase I clinical trial of adoptive transfer of autologous folate receptor-alpha redirected CAR T cells for ovarian cancer
自体叶酸受体-α重定向CAR T细胞过继转移治疗卵巢癌的I期临床试验
- 批准号:
10387023 - 财政年份:2022
- 资助金额:
$ 58.08万 - 项目类别:
Determining mechanisms of enhanced antitumor efficacy of four-day expanded Th17 cells for adoptive transfer
确定用于过继转移的四天扩增 Th17 细胞增强抗肿瘤功效的机制
- 批准号:
10248409 - 财政年份:2019
- 资助金额:
$ 58.08万 - 项目类别:
A phase I clinical study of adoptive transfer of regulatory T cells (Tregs) and low-dose interleukin-2 (IL-2) for the treatment of chronic graft-versus-host disease (GVHD): gene-marking to inform rational combination therapy
调节性 T 细胞 (Treg) 和低剂量白细胞介素 2 (IL-2) 过继转移治疗慢性移植物抗宿主病 (GVHD) 的 I 期临床研究:基因标记为合理的联合治疗提供信息
- 批准号:
nhmrc : GNT1163111 - 财政年份:2019
- 资助金额:
$ 58.08万 - 项目类别:
Project Grants
Determining mechanisms of enhanced antitumor efficacy of four-day expanded Th17 cells for adoptive transfer
确定用于过继转移的四天扩增 Th17 细胞增强抗肿瘤功效的机制
- 批准号:
10462684 - 财政年份:2019
- 资助金额:
$ 58.08万 - 项目类别:
Gene edited lymphoid progenitors for adoptive transfer as a treatment of primary immunodeficiency
基因编辑的淋巴祖细胞用于过继转移作为原发性免疫缺陷的治疗
- 批准号:
398018062 - 财政年份:2018
- 资助金额:
$ 58.08万 - 项目类别:
Research Grants
Overcoming immune suppression in cancer by targeting PSGL-1 in T cells used for adoptive transfer
通过靶向用于过继转移的 T 细胞中的 PSGL-1 克服癌症中的免疫抑制
- 批准号:
9308643 - 财政年份:2017
- 资助金额:
$ 58.08万 - 项目类别:
Overcoming immune suppression in cancer by targeting PSGL-1 in T cells used for adoptive transfer
通过靶向用于过继转移的 T 细胞中的 PSGL-1 克服癌症中的免疫抑制
- 批准号:
9447149 - 财政年份:2017
- 资助金额:
$ 58.08万 - 项目类别:
Targeting Cancer miRNAs by Adoptive Transfer of Programmed B Lymphocytes
通过程序化 B 淋巴细胞的过继转移靶向癌症 miRNA
- 批准号:
8893915 - 财政年份:2014
- 资助金额:
$ 58.08万 - 项目类别:














{{item.name}}会员




