Promoting Resilience in Early Survivorship among Adolescents and Young Adults with Cancer.

提高患有癌症的青少年和年轻人的早期生存能力。

• 批准号: 10420520
• 负责人: Abby R Rosenberg
• 金额: $ 93.03万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-10 至 2023-01-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10420520
• 关键词: Accelerometer; Address; Adolescent; Adolescent and Young Adult; Alaska; Anxiety; Award; Cancer Burden; Cancer Survivor; Cancer Survivorship; Caring; Cellular Phone; Clinical; Complement; Data; Development; Distress; Equilibrium; Evidence based program; Feeling; Goals; Gold; Guidelines; Hawaii; Health Technology; Human Resources; Intervention; Maintenance; Malignant Neoplasms; Mental Depression; Methods; Midwestern United States; Outcome; Patient Outcomes Assessments; Patients; Persons; Phase; Phenotype; Population; Psychosocial Assessment and Care; Quality of life; Randomized; Reporting; Reproducibility; Resources; Role; Self-Examination; Sequential Multiple Assignment Randomized Trial; Signal Transduction; Stress; Telephone; Text; Text Messaging; Time; Time Perception; Training; active method; anxiety symptoms; arm; base; cancer therapy; cost; design; digital; digital media; efficacy evaluation; evidence base; high risk; improved; improved outcome; innovation; instrument; intervention delivery; mHealth; medical specialties; mobile application; novel; phenotypic data; pilot test; programs; psychological distress; psychosocial; randomized trial; resilience; response; screening; secondary analysis; skills; smartphone Application; social; stress management; survivorship; telehealth; therapy design; tool; treatment as usual; trial design; video coaching; young adult

PROJECT SUMMARY Adolescents and early Young Adults (AYAs, 12-25 years-old) with cancer are at high risk of poor psychosocial outcomes because their distinct developmental challenges add to the burden of cancer. This is particularly true when AYAs transition from active treatment to cancer-surveillance (“early survivorship”) because this time demands increasing autonomy, re-integration into social, educational/vocational networks, and re-evaluation of self-identity. We created “Promoting Resilience in Stress Management” (PRISM): a novel, brief, skills-based program promoting AYA-endorsed “resilience resources” (stress-management, goal-setting, positive-reframing, and meaning-making). PRISM involves 4, 30-60 minute telehealth sessions between AYAs and certified PRISM coaches, plus an award-winning smartphone app. In a phase 2 randomized trial of 92 AYAs receiving cancer-treatment, PRISM improved patient-reported resilience, quality of life, hope, benefit-finding, and psychological distress early after its delivery, compared to usual care. While these findings were promising, they were tempered by 3 key threats to PRISM’s scalability: (1) PRISM’s delivery demands scarce human resources that might be replaced by digital media; (2) PRISM’s durability was limited after the study ended; and, (3) we lacked tools to recognize real-time changes in AYA distress that warranted additional support. Thus, we now propose a multi-center, Sequential, Multiple Assignment, Randomized Trial (SMART) to address these 3 barriers among AYA survivors of cancer. Specifically, we aim to: (1) Evaluate the efficacy of video- and text-PRISM coaching vs. the self-guided mPRISM app; (2) Determine the optimal method for maintenance of PRISM-response; and (3) Explore correlations between patient-reported resilience, distress, hope, quality of life, anxiety, and depression with validated instruments and: (a) in-app resilience and stress ratings, and (b) digital phenotype (passive smart-phone data including phone/text logs and accelerometer data). With SMART design, N=325 English or Spanish speaking AYAs from 3 diverse U.S. regions (Northwest/Alaska/Hawaii, Midwest, and South) who completed cancer-directed therapy within the past 2 years will be randomized 1:2:2 first to receive app-only, video, or text-based PRISM lay-coaching. Responders in the video- and text- arms will be randomized 1:1 second to app-only (low) maintenance or text- based (high) maintenance. Because non-response suggests a demand for more in-person engagement, text non-responders will be non-randomly assigned to video, and video non-responders will receive referrals to specialty care. Exploratory analyses will evaluate the role of in-app and digital phenotypic data in detecting real-time AYA distress. This proposal is significant because early survivorship is highly stressful for AYAs with cancer, and we propose a scalable, evidence-based program to support AYA resilience. Findings will facilitate an accessible, sustainable, evidence-based program designed to target and meet the needs of thousands of AYAs, in turn alleviating the burdens of cancer survivorship and improving their quality of life.

项目总结