Improving Black sarcoidosis patients’ care with a collaboratively developed, patient centered program

项目概要/摘要 这个K23职业发展奖的目的是发展洛根哈珀医学博士，MS作为一个 独立研究者，专注于结节病的健康差异研究。这笔资金 将允许追求他的研究计划，以发展一个以病人为中心的干预，以解决根源 在黑人结节病患者中看到的健康差异的原因。结构化指导计划 包括管理和分析大型潜在患者的实践经验 问卷调查研究，并利用社区为基础的研究技术，开发和试点测试 与黑人结节病患者合作开发的干预措施，以解决根本原因 健康差距。这种经验将补充结构化的课程， 统计和以社区为基础的研究技术。这项工作将加速 发展独立的职业道路。哈珀博士将受益于多学科 导师团队，包括结节病的世界权威丹尼尔卡尔弗博士，J达里尔博士 桑顿博士是健康差异和社区参与性研究方面的专家。 Raed Dweik是早期职业研究人员的导师。 在卡尔弗博士和桑顿博士的监督下，哈珀博士已经定量地建立了 社会因素与医疗差距的关联，以及定性访谈患者 了解结节病患者健康差异的重要介质。这项工作 支持本研究建议的可行性，其目的是1）量化 患者报告的护理障碍与患者重要结节病结局的相关性 通过前瞻性收集的调查，2）利用基于社区的研究， 制定干预措施，以解决黑色结节病患者结节病预后不良的介导因素 患者，以及3）对目标2中开发的干预措施进行局部黑色结节病的初步试验 患者确定可接受性、吸收率，并确定适当的结局和样本量 用于未来的随机对照试验该项目的完成将提供最 迄今为止，患者报告的结节病结局介质的全面表征。 此外，这项工作将奠定基础的工作，为未来的多中心集群随机 对一种新型、患者设计的干预措施进行对照试验，以减少黑人的医疗保健差异 结节病患者。在这个结构化的指导计划的培训是为了提供博士。 哈珀的框架，以寻求进一步的研究资金接近完成这一奖项，一步 朝着成为一名独立临床科学家的目标前进。

Project Summary/Abstract The purpose of this K23 Career Development Award is to develop Logan Harper MD, MS as an independent investigator with a focus in health disparity research in sarcoidosis. This funding will allow pursuit of his research plans to develop a patient centered intervention to address root causes of health disparities seen in Black sarcoidosis patients. The structured mentoring plan includes hands-on experience administering and analyzing a large prospective patient questionnaire study, and using community-based research techniques to develop and pilot test an intervention collaboratively developed with Black sarcoidosis patients to address root causes of health disparities. This experience will be supplemented with structured coursework in statistical and community-based research techniques. This work will provide accelerated development of an independent career path. Dr. Harper will benefit from a multidisciplinary team of mentors, including Dr. Daniel Culver, a world authority on sarcoidosis, Dr. J Daryl Thornton, an expert in health disparities and community-based participatory research, and Dr. Raed Dweik, a proven mentor of early career researchers. Under the supervision of Drs. Culver and Thornton, Dr. Harper has quantitatively established the association of social factors with healthcare disparities, and qualitatively interviewed patients to understand patient important mediators of health disparities in sarcoidosis. This work supports the feasibility of the present research proposal, which aims to 1) quantify the association of patient reported barriers to care with patient important sarcoidosis outcomes through prospectively collected surveys, 2) utilize community-based research to collaboratively develop an intervention to address mediators of poor sarcoidosis outcomes in Black sarcoidosis patients, and 3) pilot test the intervention developed in aim 2 with local Black sarcoidosis patients to determine acceptability, uptake, and identify appropriate outcomes and sample size for a future randomized controlled trial. Completion of the proposed project will provide the most comprehensive characterization of patient reported mediators of sarcoidosis outcomes to date. Additionally, this work will lay the ground work for a future multi-centered cluster randomized controlled trial of a novel, patient designed intervention to reduce healthcare disparities in Black sarcoidosis patients. The training in this structured mentoring plan is designed to provide Dr. Harper the framework to seek further research funding near the completion of this award, a step towards his goal of becoming an independent clinician scientist.