Improving Black sarcoidosis patients’ care with a collaboratively developed, patient centered program

项目摘要/摘要 这项K23职业发展奖的目的是将洛根·哈珀医学博士，硕士培养成 独立调查者，专注于结节病的健康差异研究。这笔资金 将允许追求他的研究计划，以开发以患者为中心的干预措施来解决根源问题 黑人结节病患者健康差异的原因。结构化的指导计划 包括管理和分析大型潜在患者的实践经验 问卷研究，并使用基于社区的研究技术来开发和试点测试 与黑色结节病患者合作开发的干预措施，以解决根本原因 健康差距的问题。这一体验将与以下课程中的结构化课程作业相补充 统计和以社区为基础的研究技术。这项工作将加速提供 发展一条独立的职业道路。哈珀博士将从一项多学科的 导师团队，包括结节病的世界权威Daniel Culver博士，J Daryl博士 桑顿博士是健康差距和基于社区的参与性研究方面的专家。 Raed Dweik，一位被证明是早期职业研究人员的导师。 在卡尔弗博士和桑顿博士的监督下，哈珀博士已经定量地建立了 社会因素与医疗保健差异的关联，并对患者进行了定性访谈 了解结节病患者健康差异的重要中介因素。这部作品 支持本研究提案的可行性，其目的是：1)量化 患者报告的护理障碍与患者重要结节病预后的关系 通过前瞻性收集的调查，2)利用基于社区的研究 制定干预措施以解决黑色结节病患者转归不良的中介因素 患者，以及3)对AIM 2中开发的干预措施进行初步测试，以治疗局部黑色结节病 患者确定可接受性、摄取性，并确定适当的结果和样本量 用于未来的随机对照试验。拟议项目的完成将提供最大的 到目前为止，患者报告的结节病转归的中介物的综合特征。 此外，这项工作还将为未来的多中心随机聚类奠定基础 一种新的、患者设计的干预措施以减少黑人医疗保健差距的对照试验 结节病患者。这一结构化指导计划中的培训旨在为Dr。 哈珀框架寻求进一步的研究资金，接近完成这个奖项，迈出了一步 朝着成为一名独立的临床科学家的目标前进。

Project Summary/Abstract The purpose of this K23 Career Development Award is to develop Logan Harper MD, MS as an independent investigator with a focus in health disparity research in sarcoidosis. This funding will allow pursuit of his research plans to develop a patient centered intervention to address root causes of health disparities seen in Black sarcoidosis patients. The structured mentoring plan includes hands-on experience administering and analyzing a large prospective patient questionnaire study, and using community-based research techniques to develop and pilot test an intervention collaboratively developed with Black sarcoidosis patients to address root causes of health disparities. This experience will be supplemented with structured coursework in statistical and community-based research techniques. This work will provide accelerated development of an independent career path. Dr. Harper will benefit from a multidisciplinary team of mentors, including Dr. Daniel Culver, a world authority on sarcoidosis, Dr. J Daryl Thornton, an expert in health disparities and community-based participatory research, and Dr. Raed Dweik, a proven mentor of early career researchers. Under the supervision of Drs. Culver and Thornton, Dr. Harper has quantitatively established the association of social factors with healthcare disparities, and qualitatively interviewed patients to understand patient important mediators of health disparities in sarcoidosis. This work supports the feasibility of the present research proposal, which aims to 1) quantify the association of patient reported barriers to care with patient important sarcoidosis outcomes through prospectively collected surveys, 2) utilize community-based research to collaboratively develop an intervention to address mediators of poor sarcoidosis outcomes in Black sarcoidosis patients, and 3) pilot test the intervention developed in aim 2 with local Black sarcoidosis patients to determine acceptability, uptake, and identify appropriate outcomes and sample size for a future randomized controlled trial. Completion of the proposed project will provide the most comprehensive characterization of patient reported mediators of sarcoidosis outcomes to date. Additionally, this work will lay the ground work for a future multi-centered cluster randomized controlled trial of a novel, patient designed intervention to reduce healthcare disparities in Black sarcoidosis patients. The training in this structured mentoring plan is designed to provide Dr. Harper the framework to seek further research funding near the completion of this award, a step towards his goal of becoming an independent clinician scientist.