Leveraging Neuroimaging Biomarkers to Understand the Role of Social Networks in Alzheimer's Disease
Leveraging Neuroimaging Biomarkers to Understand the Role of Social Networks in Alzheimer's Disease
批准号:
10426092
负责人:
LIANA G APOSTOLOVA
金额:
$67.6万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-09-15 至 2024-05-31
关键词:
AddressAdultAgeAge-associated memory impairmentAgingAlzheimer disease preventionAlzheimer&aposs DiseaseAmericanAreaAttentionBehavioralBehavioral MechanismsBiologicalBiological MarkersBiological ProcessBiosocialCaregiversCharacteristicsClinicalCognitiveDataData SetDementiaDependenceDevelopmentDiagnosisEarly DiagnosisEconomic BurdenElderlyEmotionalEtiologyExposure toFamilyFamily health statusFrequenciesFundingGoalsHealthHealth Care CostsHealthcare SystemsHomeImpaired cognitionIndianaIndividualInterventionInterviewLeadLifeLinear RegressionsLinkLiteratureLongevityMeasuresMediatingMediationMemoryMethodsModelingNerve DegenerationNeurobehavioral ManifestationsNeurologyPathway interactionsPatternPhenotypePrevalenceProcessPropertyProxyResearchResourcesRoleSamplingScienceSocial BehaviorSocial EnvironmentSocial InteractionSocial NetworkSocial ProcessesSocial ProtectionStimulusStructureSymptomsTestingThickUnited States National Institutes of Healthagedcare coordinationcognitive testingcohortconstrictiondementia riskdensitydisabilityfamily burdengray matterimprovedinsightmild cognitive impairmentneuroimagingneuroimaging markerneuropathologynovelpre-clinicalpreventranpirnaseresilienceresponsesocialsocial contactsocial engagementtool
中文摘要
项目摘要
该项目的目标是了解个人社交网络动态在
轻度认知功能障碍(MCI)和阿尔茨海默病病因及临床进展
(AD)。我们建议描述社会行为和生物学机制的特点,
社交网络与衰老相关神经病理学之间的关系。AD和痴呆症
这对个人、家庭和医疗保健系统都是毁灭性的打击。的临界点
AD的干预是社会环境,它有可能缓和潜在的
神经病理学,改变痴呆症的典型认知过程。积极的社会互动-
包括知己的数量,社会接触的频率,支持和社会参与-是
与痴呆症风险降低和认知能力下降的缓慢轨迹有关,
诊断的人。然而,现有的文献依赖于有限的和一维的
社会互动的措施,并尚未考虑潜在的生物学的作用,
神经退行性变,其在可观察到的临床认知症状之前很久就表现出来,
痴呆拟议的项目通过三个具体目标解决这些差距:目标1是确定
社交网络特征与神经退行性疾病(QNP)之间的基线关联。
目的2是研究个人社会网络动态与
神经退行性改变目的3是评估个人共同进化的替代模型
社交网络和神经退行性变化的临床认知能力下降的轨迹。的
拟议的研究是跨学科的,结合了社会和
生物医学科学,并利用AD,神经影像学和
网络科学通过增加我们对生物和社会之间联系的理解
该项目可能有助于确定新的干预目标,以减少AD的负担
对个人、家庭和医疗保健系统的影响。
英文摘要
PROJECT SUMMARY
The goal of the proposed project is to understand the role of personal social network dynamics in
the etiology and clinical progression of mild cognitive impairment (MCI) and Alzheimer disease
(AD). We propose to characterize social-behavioral and biological mechanisms underlying
relationships between social networks and aging-related neuropathology. AD and dementia takes
a devastating toll on individuals, families, and the health care system. A critical point of
intervention in AD is the social environment, which has the potential to moderate underlying
neuropathology, altering the typical cognitive course of dementia. Positive social interaction –
including number of confidants, frequency of social contact, support, and social engagement – is
associated with reduced risk for dementia and a slower trajectory of cognitive decline among
diagnosed individuals. However, the existing literature relies on limited and unidimensional
measures of social interaction, and has yet to consider the role of underlying biological
neurodegeneration, which manifests long before observable clinical cognitive symptoms of
dementia. The proposed project addresses these gaps via three specific aims: Aim 1 is to identify
baseline associations between social network characteristics and neurodegeneration (QNPs).
Aim 2 is to examine longitudinal relationships between personal social network dynamics and
neurodegenerative changes. Aim 3 is to evaluate alternative models of the coevolution of personal
social networks and neurodegenerative changes in trajectories of clinical cognitive decline. The
proposed study is interdisciplinary, combining leading-edge methods from the social and
biomedical sciences, and leveraging the resources of funded centers for AD, neuroimaging, and
network science. By increasing our understanding of the links between biological and social
processes, this project may help identify novel targets for intervention to reduce the burden of AD
on individuals, families, and the health care system.
期刊论文(5)
专著(0)
科研奖励(0)
会议论文
Personal Network Bridging Potential Across Geographic Context.
个人网络跨越地理环境的桥接潜力。
DOI:
10.1093/geronb/gbab103
发表时间:
2022
期刊:
The journals of gerontology. Series B, Psychological sciences and social sciences
影响因子:
--
作者:
[Roth,AdamR, Peng,Siyun, Perry,BreaL]
通讯作者:
Perry,BreaL
DOI:
10.1093/geronb/gbab068
发表时间:
2022-07-05
期刊:
The journals of gerontology. Series B, Psychological sciences and social sciences
影响因子:
--
作者:
[Peng S, Roth AR]
通讯作者:
Roth AR
Non-Spousal Support, Marital Status, and Mortality Risk.
非配偶赡养费、婚姻状况和死亡风险。
DOI:
10.1177/08982643211025381
发表时间:
2022
期刊:
Journal of aging and health
影响因子:
2.8
作者:
[Roth,AdamR, Peng,Siyun]
通讯作者:
Peng,Siyun
Clinical Core
-
批准号:10475176
-
项目类别:
-
资助金额:$72.91万
-
财政年份:2021
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
Clinical Core
-
批准号:10264431
-
项目类别:
-
资助金额:$74.62万
-
财政年份:2021
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
Clinical Core
-
批准号:10666612
-
项目类别:
-
资助金额:$70.37万
-
财政年份:2021
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
Leveraging Neuroimaging Biomarkers to Understand the Role of Social Networks in Alzheimer's Disease
-
批准号:10180831
-
项目类别:
-
资助金额:$70.36万
-
财政年份:2018
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
Early Onset AD Consortium - the LEAD Study (LEADS)
-
批准号:10461783
-
项目类别:
-
资助金额:$1390.41万
-
财政年份:2018
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
Early Onset AD Consortium - the LEAD Study (LEADS)
-
批准号:10219685
-
项目类别:
-
资助金额:$107.21万
-
财政年份:2018
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
Early Onset AD Consortium - the LEAD Study (LEADS)
-
批准号:9788208
-
项目类别:
-
资助金额:$1182.0万
-
财政年份:2018
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
Early Onset AD Consortium - the LEAD Study (LEADS)
-
批准号:9912388
-
项目类别:
-
资助金额:$247.33万
-
财政年份:2018
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
Leveraging Neuroimaging Biomarkers to Understand the Role of Social Networks in Alzheimer's Disease
-
批准号:9593940
-
项目类别:
-
资助金额:$73.5万
-
财政年份:2018
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
Imaging epigenetics of Alzheimer's Disease
-
批准号:9230612
-
项目类别:
-
资助金额:$14.47万
-
财政年份:2014
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
Imaging epigenetics of Alzheimer's Disease
-
批准号:8761107
-
项目类别:
-
资助金额:$14.47万
-
财政年份:2014
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
Imaging and genetic biomarkers for Alzheimer's disease
-
批准号:8634179
-
项目类别:
-
资助金额:$3.05万
-
财政年份:2013
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
Imaging and genetic biomarkers for Alzheimer's disease
-
批准号:8668864
-
项目类别:
-
资助金额:$25.83万
-
财政年份:2012
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
Imaging and genetic biomarkers for Alzheimer's disease
-
批准号:8302053
-
项目类别:
-
资助金额:$25.83万
-
财政年份:2012
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
Imaging and genetic biomarkers for Alzheimer's disease
-
批准号:8451314
-
项目类别:
-
资助金额:$25.66万
-
财政年份:2012
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
Imaging and genetic biomarkers for Alzheimer's disease
-
批准号:9229736
-
项目类别:
-
资助金额:$31.98万
-
财政年份:2012
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
FUNCTIONAL OUTCOME PREDICTORS IN NORMAL AGING, MCI AND AD
-
批准号:8363448
-
项目类别:
-
资助金额:$1.01万
-
财政年份:2011
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
IMAGING AND GENETIC BIOMARKERS FOR ALZHEIMER'S DISEASE
-
批准号:8363473
-
项目类别:
-
资助金额:$1.01万
-
财政年份:2011
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
ALZHEIMER'S DISEASE NEUROIMAGING
-
批准号:8363457
-
项目类别:
-
资助金额:$1.01万
-
财政年份:2011
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
STRUCTURAL MRI OUTCOME PREDICTORS IN MCI
-
批准号:8363437
-
项目类别:
-
资助金额:$1.01万
-
财政年份:2011
-
负责人:LIANA G APOSTOLOVA
-
依托单位:
海外基金