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Vanderbilt SCHolars in HIV and Heart, Lung, Blood, and Sleep ReSearch (V-SCHoLARS, K12)

范德比尔特艾滋病毒与心脏、肺、血液和睡眠研究学者（V-SCHoLARS，K12）

基本信息

批准号：
10429901
负责人：
MATTHEW S FREIBERG
金额：
$ 34.64万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10429901
关键词：
AIDS/HIV problem Acquired Immunodeficiency Syndrome Aging Basic Science Bioinformatics Biometry Blood Cardiopulmonary Cardiovascular system Clinical Clinical Research Cohort Studies Communicable Diseases Data Development Plans Doctor of Philosophy Educational workshop Environment Epidemiology Extramural Activities Faculty Fellowship Funding Goals Grant HIV HIV Infections Health Sciences Health Services Heart Hematology Institutes Libraries Link Location Lung Master of Science Medicine Mentored Clinical Scientist Development Program Mentors Persons Population Population Study Program Development Pulmonary Heart Disease Recording of previous events Research Research Design Research Personnel Research Project Grants Resource Development Resources SECTM1 gene Scientist Sleep Societies Southeastern United States Talents Tennessee Time Training Translational Research United States National Institutes of Health Universities Veterans antiretroviral therapy biobank career career development clinical investigation cohort comorbidity didactic education medical schools next generation programs recruit success translational clinical trial

项目摘要

With effective combination antiretroviral therapy (ART), people living with HIV/AIDS are living longer, but this success is tempered by rising rates of cardiopulmonary, hematologic, and sleep (HLBS) comorbidities in the HIV population. Vanderbilt University’s location in the Southeastern United States places it in the region with the highest rates incident HIV infection and cardiopulmonary disease. For these reasons, this application seeks to establish the Vanderbilt SCholars in HIV and Heart, Lung, Blood, And Sleep ReSearch (V-SCHoLARS, K12) program to train and mentor the next generation of HIV HLBS researchers with expertise in domains ranging from basic science to large population studies. We propose to support 5 junior faculty V-SCHoLARS who have completed an MD or PhD in the health sciences at a level of 75% effort for 2 years. Vanderbilt has a rich research environment and highly successful history of developing the careers of research scientists. Vanderbilt scholars in career development programs have an 84% success rate for extramural funding and a 70% K to R or R-equivalent conversion rate. Our proposed program, aided by Vanderbilt’s Office for Diversity Affairs, will recruit from a diverse pool of talented applicants through Vanderbilt's existing T32 grants; clinical/research fellowships in cardiovascular, pulmonary, hematology, and sleep medicine; the VA Quality Scholars Fellowship; and Meharry Medical College. Scholars will have access to 33 established NIH-funded mentors with expertise in HIV/infectious disease, cardiovascular, pulmonary, hematology, or sleep medicine who have a demonstrated track record of mentoring early career scholars, as well as 14 topic experts in the fields of basic science, clinical trials/translational research, population/epidemiology, health services/operational research, and biostatistics and bioinformatics. The program will have 4 major components: (1) formal mentoring (each scholar will have a paired HIV and an HLBS mentor), 2) didactic education that includes an opportunity to obtain a Master of Science in Clinical Investigation, 3) guaranteed protected time, and 4) a mentored research project that will be submitted as part of career development grant in year two. Each Scholar will have an individualized development plan with milestones tailored to their scientific background, training needs, and career goals. Scholars will have access to institutional resources including the Vanderbilt Institute for Clinical and Translational Research, the Tennessee Center for AIDS Research, existing cohort data (e.g., Veterans Aging Cohort Study), biostatistical support, 50 research cores, and BioVu, one of the world’s largest clinically linked biobanks. Scholars will also be supported by a range of career development resources: interdisciplinary expert consultant studios to vet scientific ideas, aims, and research designs; a K08/K23/R01 funded grant library; grant workshops; work-in-progress sessions; and research seminars through the Newman Society, a professional group for all career development awardees at Vanderbilt. Taken together, Vanderbilt provides an optimal environment for developing a diverse, well-trained next generation of HIV HLBS researchers.

通过有效的联合抗逆转录病毒疗法（ART），艾滋病毒/艾滋病感染者的寿命延长，但这成功受到心肺、血液和睡眠（HLBS）合并症发生率上升的影响，艾滋病毒感染者。范德比尔特大学位于美国东南部，艾滋病毒感染和心肺疾病的发病率最高。因此，本申请寻求建立范德比尔特Scholars在艾滋病毒和心脏，肺，血液和睡眠研究（V-SCHoLARS，K12）该计划旨在培训和指导下一代HIV HLBS研究人员，他们在以下领域具有专业知识：从基础科学到大规模人口研究。我们建议支持5个初级教师V-SCHOLARS谁拥有在2年内以75%的努力完成健康科学的MD或PhD。范德比尔特有一个丰富的研究环境和发展研究科学家职业生涯的高度成功的历史。范德比尔特职业发展项目的学者有84%的校外资金成功率和70%的K到R 或R当量转换率。在范德比尔特多样性事务办公室的帮助下，我们提出的计划将通过范德比尔特现有的T32赠款从各种有才华的申请人中招募;临床/研究心血管、肺、血液学和睡眠医学奖学金; VA质量学者奖学金;和梅哈里医学院。学者将有机会获得33个既定的NIH资助的导师具有HIV/传染病、心血管、肺、血液学或睡眠医学方面的专业知识，展示了指导早期职业学者的跟踪记录，以及基础领域的14个主题专家科学、临床试验/转化研究、人口/流行病学、卫生服务/业务研究，以及生物统计学和生物信息学。该计划将有4个主要组成部分：（1）正式指导（每个学者将有一对艾滋病毒和HLBS导师），2）教学教育，包括一个机会，获得临床研究理学硕士学位，3）有保障的保护时间，4）指导研究该项目将在第二年作为职业发展补助金的一部分提交。每个学者将有一个个性化的发展计划，其中包含根据其科学背景、培训需求和职业目标。学者将有机会获得机构资源，包括范德比尔特临床研究所和转化研究，田纳西州艾滋病研究中心，现有的队列数据（例如，退伍军人老龄化队列研究），生物统计支持，50个研究核心，以及BioVu，世界上最大的临床链接的生物银行学者还将得到一系列职业发展资源的支持：跨学科专家顾问工作室审查科学思想，目标和研究设计; K 08/K23/R 01资助的赠款图书馆;赠款讲习班;工作进展会议;和研究研讨会通过纽曼协会，一个职业发展奖获得者在范德比尔特。总之，范德比尔特提供了一个为培养多样化、训练有素的下一代HIV HLBS研究人员提供了最佳环境。