Administrative, Education, and Analytic Support Core
行政、教育和分析支持核心
基本信息
- 批准号:10685508
- 负责人:
- 金额:$ 14.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-10 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdvisory CommitteesAgingAlcohol consumptionAlcoholic beverage heavy drinkerAlcoholsAreaBile AcidsBiological MarkersBiological Specimen BanksBiometryBloodBostonBudgetsCardiovascular DiseasesCause of DeathCessation of lifeClinical Trials Data Monitoring CommitteesCohort StudiesCollaborationsDataDiseaseEducationEventFosteringFundingFutureGoalsGrantHIVHIV InfectionsHIV/AIDSHeartInflammationInfrastructureInterventionLaboratoriesLeadLeadershipLungMentored Clinical Scientist Development ProgramMentorshipMetabolic PathwayMetagenomicsMonitorNational Heart, Lung, and Blood InstituteNational Institute on Alcohol Abuse and AlcoholismPersonsPoliciesPopulationPreparationProbioticsProceduresProgram Research Project GrantsProgress ReportsProtocols documentationPublicationsRandomized, Controlled TrialsResearchResearch PersonnelResourcesRisk FactorsRussiaServicesSiteSleepSpecimenTeacher Professional DevelopmentTestingTrainingTraining ProgramsTranslational ResearchUgandaUnited States National Institutes of HealthUniversitiesUniversity resourcesVeteransVolatile Fatty AcidsWorkZincalcohol researchbiobankcardiovascular disorder epidemiologycardiovascular disorder riskcardiovascular risk factorcohortdata repositorydisorder riskdysbiosisepidemiology studyexperiencefollow-upgastrointestinalgut dysbiosisgut microbiomehigh riskimprovedinterestmeetingsmetabolomicsmicrobialmicrobiomemicrobiome researchmodifiable riskmortality riskmultidisciplinarynutritionprogram disseminationprogramsrecruitsynergismtrial designtrimethyloxamine
项目摘要
Alcohol consumption is an important modifiable cardiovascular disease (CVD) risk factor among people living
with HIV infection (PLWH). Given that alcohol use is common among PLWH, and CVD is a leading non-AIDS
disease and cause of death among PLWH, addressing alcohol consumption in this population is critically
important. The Microbiome, mETabolites, and Alcohol in HIV to reduce CVD Program Project Grant (PPG) is a
multidisciplinary group of investigators with expertise in alcohol, HIV, gut microbiome, biomarker research,
nutrition, and randomized controlled trial (RCT) design. Our overarching hypothesis for this P01 application
is that among PLWH, a probiotic can mitigate alcohol associated dysbiosis and lower levels of microbial
translocation, inflammation, and improve metabolite profiles (Project 1); and that harmful levels of these
metabolites are associated with higher risk of CVD and death events (Project 2). To test this hypothesis, this
PPG will leverage the Veterans Aging Cohort Study, the Uganda Russia Boston Alcohol Network for Alcohol
Research Collaboration on HIV/AIDS, the Integrated Metagenomic and Metabolomic Core (IMMC) at the
University of Louisville Alcohol Research Center, and the Vanderbilt SCHolars in HIV and Heart, Lung, Blood,
and Sleep ReSearch NIH K12 junior faculty training program to accomplish these objectives: (1) To determine
if a probiotic tailored for alcohol associated gut dysbiosis mitigates this dysbiosis, microbial translocation,
inflammation, harmful metabolites, CVD and mortality risk (Project 1 RCT, Lead Freiberg); (2) To assess the
association between alcohol use, CVD and death via three metabolic pathways among PLWH (Project 2
Cohort, Lead So-Armah); (3) To provide metabolomic and biomarker laboratory resources (IMMC, Lead
Barve); (4) Administrative leadership and services to support the proposed research (Admin Core, Leads
Freiberg and Barve); and (5) Encourage and develop future trainees. The Administrative (Admin) Core will be
responsible for day-to-day management and functioning of the PPG. The Admin Core goal is to ensure that
the scientific and programmatic activities of the PPG are conducted per protocol in a timely fashion, within
budget, and with the highest quality. The Admin Core has these specific aims: (1) To provide administrative
oversight of the PPG, including assembling a steering committee, program advisory committee, and data
safety monitoring board, and developing the policies and procedures necessary to successfully organize and
complete our specific aims and training initiatives; (2) To provide services to PPG investigators and trainees
(e.g., study progress reports, compliance assurance, assistance with presentations and publications), and to
promote/disseminate the PPG'S work; (3) To provide resources (e.g., data and specimens), biostatistical
support, and mentorship to new investigators ; (4) To promote synergy within and across other funded PPGs;
(5) To monitor progress and compliance of the PPG's components, implement improvement mechanisms if
necessary, and assist investigators with challenges (e.g., recruitment).
饮酒是生活在美国的人中一个重要的可改变的心血管疾病(CVD)风险因素。
艾滋病毒感染者(PLWH)。鉴于饮酒在艾滋病病毒携带者中很常见,而心血管疾病是艾滋病病毒携带者中的主要非艾滋病病毒携带者。
艾滋病毒携带者的疾病和死亡原因,解决这一人群的饮酒问题至关重要
重要. HIV中的微生物组、代谢产物和酒精,以减少CVD计划项目补助金(PPG)是一项
多学科的研究小组,在酒精,艾滋病毒,肠道微生物组,生物标志物研究,
营养和随机对照试验(RCT)设计。我们对P01应用的总体假设
在PLWH中,益生菌可以减轻酒精相关的生态失调,并降低微生物水平,
易位,炎症,并改善代谢产物谱(项目1);以及这些有害水平
代谢物与CVD和死亡事件的高风险相关(项目2)。为了验证这一假设,
PPG将利用退伍军人老龄化队列研究,乌干达俄罗斯波士顿酒精网络酒精
艾滋病毒/艾滋病研究合作,综合宏基因组学和代谢组学核心(IMMC)
路易斯维尔大学酒精研究中心和范德比尔特大学艾滋病毒与心脏、肺、血液领域的学者
和睡眠研究NIH K12初级教师培训计划,以实现这些目标:(1)确定
如果为酒精相关的肠道生态失调定制的益生菌减轻了这种生态失调,微生物易位,
炎症、有害代谢物、CVD和死亡风险(项目1 RCT,负责人弗赖贝格);(2)评估
PLWH中通过三种代谢途径的酒精使用、CVD和死亡之间的关联(项目2
(3)提供代谢组学和生物标志物实验室资源(IMMC,牵头
Barve);(4)支持拟议研究的行政领导和服务(行政核心,领导
弗赖贝格和巴夫);和(5)鼓励和发展未来的学员。行政核心(Admin Core)
负责PPG的日常管理和运作。管理核心的目标是确保
PPG的科学和计划活动按照协议及时进行,
预算,并以最高的质量。管理核心有这些具体目标:(1)提供行政
监督PPG,包括组建指导委员会,计划咨询委员会和数据
安全监督委员会,并制定必要的政策和程序,以成功地组织和
完成我们的具体目标和培训计划;(2)为PPG研究者和学员提供服务
(e.g.,研究进展报告、合规性保证、演示文稿和出版物方面的协助),以及
促进/宣传PPG的工作;(3)提供资源(例如,数据和样本),生物统计学
(4)促进其他获资助的项目规划小组内部和之间的协同作用;
(5)为了监测PPG各组成部分的进度和合规性,在以下情况下实施改进机制:
必要的,并协助调查人员与挑战(例如,招聘)。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MATTHEW S FREIBERG其他文献
MATTHEW S FREIBERG的其他文献
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{{ truncateString('MATTHEW S FREIBERG', 18)}}的其他基金
Microbiome, metabolites, and alcohol in HIV to reduce CVD RCT (META HIV CVD RCT)
HIV 中的微生物组、代谢物和酒精可减少 CVD 的随机对照试验 (META HIV CVD RCT)
- 批准号:
10685513 - 财政年份:2021
- 资助金额:
$ 14.1万 - 项目类别:
Administrative, Education, and Analytic Support Core
行政、教育和分析支持核心
- 批准号:
10304047 - 财政年份:2021
- 资助金额:
$ 14.1万 - 项目类别:
Microbiome, metabolites, and alcohol in HIV to reduce CVD RCT (META HIV CVD RCT)
HIV 中的微生物组、代谢物和酒精可减少 CVD 的随机对照试验 (META HIV CVD RCT)
- 批准号:
10685704 - 财政年份:2021
- 资助金额:
$ 14.1万 - 项目类别:
Microbiome, metabolites, and alcohol in HIV to reduce CVD RCT (META HIV CVD RCT)
HIV 中的微生物组、代谢物和酒精可减少 CVD 的随机对照试验 (META HIV CVD RCT)
- 批准号:
10304049 - 财政年份:2021
- 资助金额:
$ 14.1万 - 项目类别:
Vanderbilt SCHolars in HIV and Heart, Lung, Blood, and Sleep ReSearch (V-SCHoLARS, K12)
范德比尔特艾滋病毒与心脏、肺、血液和睡眠研究学者(V-SCHoLARS,K12)
- 批准号:
10429901 - 财政年份:2018
- 资助金额:
$ 14.1万 - 项目类别:
Vanderbilt SCHolars in HIV and Heart, Lung, Blood, and Sleep ReSearch (V-SCHoLARS, K12)
范德比尔特艾滋病毒与心脏、肺、血液和睡眠研究学者(V-SCHoLARS,K12)
- 批准号:
10202711 - 财政年份:2018
- 资助金额:
$ 14.1万 - 项目类别:
Vanderbilt SCHolars in HIV and Heart, Lung, Blood, and Sleep ReSearch (V-SCHoLARS, K12)
范德比尔特艾滋病毒与心脏、肺、血液和睡眠研究学者(V-SCHoLARS,K12)
- 批准号:
9761561 - 财政年份:2018
- 资助金额:
$ 14.1万 - 项目类别:
ST. PETER HIV-Alcohol, Protein Biomarkers and Cardiovascular Disease Risk
英石。
- 批准号:
9349871 - 财政年份:2017
- 资助金额:
$ 14.1万 - 项目类别:
ST. PETER HIV-Alcohol, Protein Biomarkers and Cardiovascular Disease Risk
英石。
- 批准号:
9770731 - 财政年份:2017
- 资助金额:
$ 14.1万 - 项目类别:
Immune function and the risk of cvd among HIV infected and uninfected veterans
HIV感染者和未感染者的免疫功能和CVD风险
- 批准号:
9268918 - 财政年份:2014
- 资助金额:
$ 14.1万 - 项目类别:
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