Administrative, Education, and Analytic Support Core
行政、教育和分析支持核心
基本信息
- 批准号:10685508
- 负责人:
- 金额:$ 14.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-10 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdvisory CommitteesAgingAlcohol consumptionAlcoholic beverage heavy drinkerAlcoholsAreaBile AcidsBiological MarkersBiological Specimen BanksBiometryBloodBostonBudgetsCardiovascular DiseasesCause of DeathCessation of lifeClinical Trials Data Monitoring CommitteesCohort StudiesCollaborationsDataDiseaseEducationEventFosteringFundingFutureGoalsGrantHIVHIV InfectionsHIV/AIDSHeartInflammationInfrastructureInterventionLaboratoriesLeadLeadershipLungMentored Clinical Scientist Development ProgramMentorshipMetabolic PathwayMetagenomicsMonitorNational Heart, Lung, and Blood InstituteNational Institute on Alcohol Abuse and AlcoholismPersonsPoliciesPopulationPreparationProbioticsProceduresProgram Research Project GrantsProgress ReportsProtocols documentationPublicationsRandomized, Controlled TrialsResearchResearch PersonnelResourcesRisk FactorsRussiaServicesSiteSleepSpecimenTeacher Professional DevelopmentTestingTrainingTraining ProgramsTranslational ResearchUgandaUnited States National Institutes of HealthUniversitiesUniversity resourcesVeteransVolatile Fatty AcidsWorkZincalcohol researchbiobankcardiovascular disorder epidemiologycardiovascular disorder riskcardiovascular risk factorcohortdata repositorydisorder riskdysbiosisepidemiology studyexperiencefollow-upgastrointestinalgut dysbiosisgut microbiomehigh riskimprovedinterestmeetingsmetabolomicsmicrobialmicrobiomemicrobiome researchmodifiable riskmortality riskmultidisciplinarynutritionprogram disseminationprogramsrecruitsynergismtrial designtrimethyloxamine
项目摘要
Alcohol consumption is an important modifiable cardiovascular disease (CVD) risk factor among people living
with HIV infection (PLWH). Given that alcohol use is common among PLWH, and CVD is a leading non-AIDS
disease and cause of death among PLWH, addressing alcohol consumption in this population is critically
important. The Microbiome, mETabolites, and Alcohol in HIV to reduce CVD Program Project Grant (PPG) is a
multidisciplinary group of investigators with expertise in alcohol, HIV, gut microbiome, biomarker research,
nutrition, and randomized controlled trial (RCT) design. Our overarching hypothesis for this P01 application
is that among PLWH, a probiotic can mitigate alcohol associated dysbiosis and lower levels of microbial
translocation, inflammation, and improve metabolite profiles (Project 1); and that harmful levels of these
metabolites are associated with higher risk of CVD and death events (Project 2). To test this hypothesis, this
PPG will leverage the Veterans Aging Cohort Study, the Uganda Russia Boston Alcohol Network for Alcohol
Research Collaboration on HIV/AIDS, the Integrated Metagenomic and Metabolomic Core (IMMC) at the
University of Louisville Alcohol Research Center, and the Vanderbilt SCHolars in HIV and Heart, Lung, Blood,
and Sleep ReSearch NIH K12 junior faculty training program to accomplish these objectives: (1) To determine
if a probiotic tailored for alcohol associated gut dysbiosis mitigates this dysbiosis, microbial translocation,
inflammation, harmful metabolites, CVD and mortality risk (Project 1 RCT, Lead Freiberg); (2) To assess the
association between alcohol use, CVD and death via three metabolic pathways among PLWH (Project 2
Cohort, Lead So-Armah); (3) To provide metabolomic and biomarker laboratory resources (IMMC, Lead
Barve); (4) Administrative leadership and services to support the proposed research (Admin Core, Leads
Freiberg and Barve); and (5) Encourage and develop future trainees. The Administrative (Admin) Core will be
responsible for day-to-day management and functioning of the PPG. The Admin Core goal is to ensure that
the scientific and programmatic activities of the PPG are conducted per protocol in a timely fashion, within
budget, and with the highest quality. The Admin Core has these specific aims: (1) To provide administrative
oversight of the PPG, including assembling a steering committee, program advisory committee, and data
safety monitoring board, and developing the policies and procedures necessary to successfully organize and
complete our specific aims and training initiatives; (2) To provide services to PPG investigators and trainees
(e.g., study progress reports, compliance assurance, assistance with presentations and publications), and to
promote/disseminate the PPG'S work; (3) To provide resources (e.g., data and specimens), biostatistical
support, and mentorship to new investigators ; (4) To promote synergy within and across other funded PPGs;
(5) To monitor progress and compliance of the PPG's components, implement improvement mechanisms if
necessary, and assist investigators with challenges (e.g., recruitment).
饮酒是人们生活中一个重要的可改变的心血管疾病(CVD)危险因素
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MATTHEW S FREIBERG其他文献
MATTHEW S FREIBERG的其他文献
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{{ truncateString('MATTHEW S FREIBERG', 18)}}的其他基金
Microbiome, metabolites, and alcohol in HIV to reduce CVD RCT (META HIV CVD RCT)
HIV 中的微生物组、代谢物和酒精可减少 CVD 的随机对照试验 (META HIV CVD RCT)
- 批准号:
10685513 - 财政年份:2021
- 资助金额:
$ 14.1万 - 项目类别:
Administrative, Education, and Analytic Support Core
行政、教育和分析支持核心
- 批准号:
10304047 - 财政年份:2021
- 资助金额:
$ 14.1万 - 项目类别:
Microbiome, metabolites, and alcohol in HIV to reduce CVD RCT (META HIV CVD RCT)
HIV 中的微生物组、代谢物和酒精可减少 CVD 的随机对照试验 (META HIV CVD RCT)
- 批准号:
10685704 - 财政年份:2021
- 资助金额:
$ 14.1万 - 项目类别:
Microbiome, metabolites, and alcohol in HIV to reduce CVD RCT (META HIV CVD RCT)
HIV 中的微生物组、代谢物和酒精可减少 CVD 的随机对照试验 (META HIV CVD RCT)
- 批准号:
10304049 - 财政年份:2021
- 资助金额:
$ 14.1万 - 项目类别:
Vanderbilt SCHolars in HIV and Heart, Lung, Blood, and Sleep ReSearch (V-SCHoLARS, K12)
范德比尔特艾滋病毒与心脏、肺、血液和睡眠研究学者(V-SCHoLARS,K12)
- 批准号:
10429901 - 财政年份:2018
- 资助金额:
$ 14.1万 - 项目类别:
Vanderbilt SCHolars in HIV and Heart, Lung, Blood, and Sleep ReSearch (V-SCHoLARS, K12)
范德比尔特艾滋病毒与心脏、肺、血液和睡眠研究学者(V-SCHoLARS,K12)
- 批准号:
10202711 - 财政年份:2018
- 资助金额:
$ 14.1万 - 项目类别:
Vanderbilt SCHolars in HIV and Heart, Lung, Blood, and Sleep ReSearch (V-SCHoLARS, K12)
范德比尔特艾滋病毒与心脏、肺、血液和睡眠研究学者(V-SCHoLARS,K12)
- 批准号:
9761561 - 财政年份:2018
- 资助金额:
$ 14.1万 - 项目类别:
ST. PETER HIV-Alcohol, Protein Biomarkers and Cardiovascular Disease Risk
英石。
- 批准号:
9349871 - 财政年份:2017
- 资助金额:
$ 14.1万 - 项目类别:
ST. PETER HIV-Alcohol, Protein Biomarkers and Cardiovascular Disease Risk
英石。
- 批准号:
9770731 - 财政年份:2017
- 资助金额:
$ 14.1万 - 项目类别:
Immune function and the risk of cvd among HIV infected and uninfected veterans
HIV感染者和未感染者的免疫功能和CVD风险
- 批准号:
9268918 - 财政年份:2014
- 资助金额:
$ 14.1万 - 项目类别:
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Standard Grant














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