TRAINING GRANT IN MOLECUCLAR IMAGING RESEARCH AND CANCER SYSTEMS ANALYSIS

我们有一个首要目标：培养有资格和条件的博士后研究员 领导下一代技术的开发和应用，以了解 癌症的异质性和不断变化的细胞和分子格局。具体来说，我们建议 继续2-3年的博士后研究，将吸引最优秀和最聪明的人，具有强大的 致力于各种背景的跨学科研究，包括工程学、生物学、 化学和计算科学帮助培养多元化的下一代科学领导者 癌症分析。细胞癌的诊断对于建立正确的诊断、指导 适当的治疗，评估患者进入临床试验的资格，确定治疗效果，重新分期 疾病和在系统水平上了解癌症的异质性。将成像工具结合在一起， 基于人工智能(AI)的图像分析、细胞分析、癌症基因组学、计算机科学和 免疫学将是解决肿瘤学问题和找到创新解决方案所必需的，这些解决方案可以扩大 将从常规、靶向和免疫疗法中受益的癌症患者数量。我们提供很高的 高质量的受训者，有一段时间的资金，这样他们就可以接触到：a)仔细指导的研究经验 在进行和有效沟通跨学科研究的自主性增强的时期；b) 最佳的教学体验；c)最具创新性和尖端的工具和思维 这些问题和d)通过在一个 丰富的癌症中心环境。我们有着出色的成功记录：我们的同事们创造了 388篇发表在同行评议期刊上的论文。在完成培训的49名博士后研究员中，有47人在 26人(52%)已经是教授。34名非凡导师的教职员工一直在谨慎地 根据他们表现出的对受训人员独立性的承诺而被选中，令人兴奋和 要解决的重要生物问题，以及稳定的资金。教职员工都有很高的造诣， 总共获得200多项校外研究资助。最近，培训计划一直是 通过a)扩大的专题方案(例如系统药理学、药物输送、 免疫疗法，单细胞分析)，b)新系列讲座，c)扩大生物工程设施。带着我们的 现有的师资，增强的设施，支持的研究范围和过去的成就，我们提供 为下一代临床医生和科学家提供卓越的研究环境，接受分子方面的培训 成像和系统分析。

We have one overarching goal: Train postdoctoral fellows who will be qualified and well-positioned to lead in the development and application of next generation technologies to understand the heterogenous and changing cellular and molecular landscape of cancers. Specifically, we propose to continue a 2-3 year postdoctoral fellowship that will attract the best and brightest individuals with a strong commitment to transdisciplinary research from a wide variety of backgrounds including engineering, biological, chemical and computational sciences to help build the next generation of scientific leaders in multiplexed cancer analysis. Cellular cancer diagnostics are essential in establishing the correct diagnosis, guiding the appropriate treatment, assessing patient eligibility into clinical trials, determining therapeutic efficacy, re-staging disease and understanding cancer heterogeneity at a systems level. Bringing together the tools of imaging, artificial intelligence (AI) based image analysis, cellular analyses, cancer genomics, computer science, and immunology will be necessary to solve problems in oncology and find innovative solutions that can expand the number of cancer patients who will benefit from conventional, targeted and immunotherapies. We provide high quality trainees with a period of funding so they can be exposed to: a) carefully mentored research experiences during periods of increasing autonomy to conduct and effectively communicate transdisciplinary research; b) optimal didactic experiences; c) the most innovative and cutting-edge tools and thinking with which to attack these problems and d) broad exposure to the most pressing cancer problems today through interactions in a rich cancer center environment. We have an outstanding track record of success: our fellows have produced 388 papers in peer reviewed journals. Of the 49 postdoctoral fellows who have completed training, 47 are in research and 26 (52%) are already professors. The faculty of 34 extraordinary mentors has been carefully selected on the basis of their demonstrated commitment to the independence of their trainees, exciting and important biologic problems on which to work, and stable funding. The faculty are all highly accomplished and collectively receive over 200 extramural research grants. More recently, the training program has been considerably strengthened by a) expanded thematic programs (e.g. systems pharmacology, drug delivery, immunotherapies, single cell analyses), b) new lecture series, c) an expanded bioengineering facility. With our current faculty, enhanced facilities, scope of supported research and past accomplishments, we offer an outstanding research environment for the next generation of clinicians and scientists to be trained in molecular imaging and systems analysis.