Defining the structural basis of lipid mediated T cell immunity

定义脂质介导的 T 细胞免疫的结构基础

• 批准号: DE210101031
• 负责人: Dr Adam Shahine
• 金额: $ 32.23万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE210101031
• 关键词: Defining; structural; basis; lipid; mediated

This project aims to undertake discovery research to investigate the molecular mechanisms underpinning the role of lipids in T cell immunity: an emerging area of immense biological significance. The anticipated goal is to generate new knowledge in the areas of the life sciences, by using a multidisciplinary approach that includes structural biology, mass spectrometry, biophysics, and cellular immunology, to gain fundamental insight into molecular determinants that govern lipid mediated immunity. Expected outcomes and benefits of this project include building international and interdisciplinary collaborations to enhance national research capacity, and provide marked advancement of core knowledge in the biological sciences.

该项目旨在进行发现研究，以研究脂质在T细胞免疫中作用的分子机制：这是一个具有巨大生物学意义的新兴领域。预期的目标是通过使用包括结构生物学，质谱，生物物理学和细胞免疫学在内的多学科方法，在生命科学领域产生新的知识，以获得对控制脂质介导的免疫的分子决定因素的基本见解。该项目的预期成果和效益包括建立国际和跨学科合作，以增强国家研究能力，并显着推进生物科学核心知识。