POINTER-zzz: Sleep Ancillary to U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk of Alzheimer's Disease - Admin

POINTER-zzz：美国研究通过睡眠辅助通过生活方式干预降低阿尔茨海默病风险来保护大脑健康 - 管理员

• 批准号: 10429446
• 负责人: Laura D. Baker
• 金额: $ 33.76万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10429446
• 关键词: Administrative Supplement; Alzheimer' s disease risk; Ancillary Study; Blood Vessels; Blood flow; Cerebrum; Cognitive; Data; Dementia; Elderly; Enrollment; Funding; Health; Hispanics; Homeostasis; Impaired cognition; Individual; Intervention Studies; Intervention Trial; Life Style; Link; Measures; Minority Groups; Outcome; Parents; Participant; Peripheral; Risk; Risk Reduction; Sleep; Sleep Apnea Syndromes; Underrepresented Populations; Vascular Diseases; Vasomotor; brain health; cardiovascular disorder risk; cardiovascular health; cohort; ethnic diversity; ethnic minority population; high risk; improved; lifestyle intervention; neurovascular; precision medicine; racial diversity; racial minority; recruit; sleep quality

PROJECT SUMMARY To date, greater than 30% of enrolled POINTER-zzz participants are from under-represented racial and ethnic minority groups. A second NIA-funded ancillary study to the parent U.S. POINTER trial, POINTER- Neurovascular (POINTER-NV), presents a unique opportunity to increase the scientific impact of POINTER- zzz by allowing co-examination objective measures of sleep with peripheral and central measures of blood flow in a racially and ethnically diverse group of participants. This Administrative Supplement will allow us to increase co-participation of individuals from under-represented groups in the two ancillary studies to examine links between lifestyle-induced changes in sleep as they relate to lifestyle-induced changes in vascular health. Lifestyle intervention has the potential to improve sleep quality and reduce incident sleep apnea, which has been bi-directionally linked to vascular disease in older adults. One potent health target for the POINTER lifestyle intervention is cardiovascular health, which is disproportionately more prevalent in racial and ethnic minority older adults. Thus, the opportunity to co-enroll additional participants who are at high risk for cardiovascular disease into POINTER-zzz could contribute new important information to inform precision medicine strategies targeting AD risk reduction in older adults at risk for cognitive decline and dementia.

项目概要 迄今为止，超过 30% 的 POINTER-zzz 参与者来自代表性不足的种族和民族 少数群体。第二项由 NIA 资助的美国 POINTER 试验的辅助研究 POINTER- 神经血管 (POINTER-NV) 提供了一个独特的机会来提高 POINTER- 的科学影响力 zzz 通过允许同时检查客观的睡眠测量和外周和中枢血流量测量 在不同种族和民族的参与者群体中。本行政补充文件将使我们能够 增加来自代表性不足群体的个人在两项辅助研究中的共同参与，以检验 生活方式引起的睡眠变化与生活方式引起的血管健康变化之间的联系。 生活方式干预有可能改善睡眠质量并减少睡眠呼吸暂停事件，这已 与老年人的血管疾病双向相关。 POINTER 的一项有效健康目标 生活方式干预是心血管健康，这在种族和民族中更为普遍 少数民族老年人。因此，有机会共同招募其他高风险参与者 POINTER-zzz 中的心血管疾病可以为精确度提供新的重要信息 针对有认知能力下降和痴呆风险的老年人降低 AD 风险的医学策略。