REC Core

记录核心

• 批准号: 10461188
• 负责人: Laura D. Baker
• 金额: $ 10.79万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10461188
• 关键词: Address; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Award; Basic Science; Biological Markers; Brain imaging; Capsicum; Characteristics; Clinical; Clinical Sciences; Cognitive aging; Collaborations; Competence; Development; Discipline; Diverse Workforce; Educational Curriculum; Educational workshop; Elderly; Ensure; Etiology; Faculty; Fostering; Foundations; Funding; Geriatrics; Gerontology; Goals; Grant; Image Analysis; Institutes; Institution; Journals; Knowledge; Leadership; Measurement; Medicine; Mentors; Mentorship; Metabolic; Modeling; Multi-site clinical study; NCI Scholars Program; Pathogenesis; Pathologic; Postdoctoral Fellow; Prevention; Principal Investigator; Recording of previous events; Research; Research Personnel; Research Project Summaries; Resources; Rodent; Schools; Science; Scientist; Training; Training Programs; Training Support; Training and Education; Translational Research; Underrepresented Populations; United States National Institutes of Health; Work; Writing; career; career development; cognitive testing; education research; experience; faculty research; forest; graduate student; healthy aging; instructor; interest; member; mid-career faculty; mild cognitive impairment; multidisciplinary; next generation; nonhuman primate; professor; programs; recruit; research and development; skills; student training; symposium; translational impact; undergraduate student; vascular risk factor

Research Education Component – Project Summary The Research Education Component will collaborate with other ADRC Cores and affiliate members to provide critical training and education to build a pipeline of new investigators from diverse backgrounds and with the necessary research interests and skills to meaningfully contribute to ADRD research – particularly with regard to metabolic and vascular risk factors underlying ADRD pathogenesis. In the last 4 years, we supported training of 20 graduate students and 8 postdoctoral fellows, and intensive mentoring for 17 junior faculty – 70% of whom now serve as Principal Investigators on 22 NIH or foundation ADRD grants. In the next cycle, REC programs will continue to leverage unique strengths and resources of the institution and the ADRC, particularly with regard to our experiences conducting ADRD translational research – from cellular mechanisms through rodent and nonhuman primate models to large-scale multi-site clinical studies. The REC Scholars Program will provide individualized and comprehensive training to junior investigators with clinical or basic science expertise to facilitate expansion of their work to support key concepts in translational science that could be instrumental in identifying effective strategies for ADRD prevention and treatment. The REC will also develop and deliver an extensive portfolio of ADRD-related educational programming for undergraduates, graduate students, fellows, and investigators from other disciplines to further expand the new investigator pipeline through ADRC interactions with Pepper OAIC, CTSI and other institutional programs. Given Wake Forest’s well-known and successful history conducting large multi-site clinical studies in older adults, a focus of the REC training program will include Team Science to provide new investigators with the skills to ensure successful project management, development of strong and sustainable collaborations, and effective leadership of multidisciplinary teams. Such teams will be essential for scientific discovery targeting prevention and treatment of ADRDs, which are characteristically heterogeneous in clinical presentation, etiology, and pathologic trajectory.

研究教育部分 - 项目摘要 研究教育部分将与其他ADRC核心和会员成员合作，以提供 批判性培训和教育，以建立来自潜水员背景的新调查员的管道以及 必要的研究兴趣和技能，有意义地为ADRD研究做出贡献 - 尤其是在方面 为ADRD发病机理的代谢和血管危险因素。在过去的四年中，我们支持 培训20名研究生和8位博士后研究员，并为17名初级教师进行深入训练 - 70％ 现在，他们担任NIH或基金会ADRD赠款的首席调查员。在下一个周期中 计划将继续利用机构和ADRC的独特优势和资源，特别是 关于我们进行ADRD翻译研究的经验 - 从细胞机制到 啮齿动物和非人类私人模型，用于大规模多站点临床研究。 REC学者计划将 为具有临床或基础科学专业知识的初级研究人员提供个性化和全面的培训 促进他们的工作扩展以支持转化科学中的关键概念，这些概念可能是工具性的 在确定预防和治疗的有效策略时。 Rec还将开发并提供 针对本科生，研究生，研究员，研究生，研究生，研究生，研究生的教育计划的广泛投资组合 以及其他学科的研究人员通过ADRC进一步扩展新的研究者管道 与胡椒OAIC，CTSI和其他机构计划的互动。鉴于Wake Forest的知名和 在老年人中进行大型多站点临床研究的成功历史，这是REC培训的重点 计划将包括团队科学，为新调查人员提供确保成功项目的技能 管理，建立强大而可持续的合作以及有效的领导 多学科团队。此类团队对于针对预防和治疗的科学发现至关重要 ADRD，在临床表现，病因和病理学中特征是异质的 弹道。