REC Core

研究教育部分--项目摘要 研究教育部分将与ADRC的其他核心和附属成员合作，以提供 关键的培训和教育，以建立一个渠道，新的调查人员来自不同的背景和 必要的研究兴趣和技能，以对ADRD的研究做出有意义的贡献--特别是在 导致ADRD发病的代谢和血管危险因素。在过去的4年里，我们支持 培训20名研究生和8名博士后研究员，对17名初级教员进行强化指导--70% 其中22人现在是美国国立卫生研究院或ADRD基金会的首席研究员。在下一个周期中，REC 这些方案将继续利用该机构和亚洲发展研究中心的独特优势和资源，特别是 关于我们进行ADRD翻译研究的经验--从细胞机制到 啮齿动物和非人灵长类动物模型的大规模多点临床研究。REC学者计划将 为具有临床或基础科学专业知识的初级研究人员提供个性化和全面的培训 促进扩大他们的工作，以支持翻译科学中可能具有工具性的关键概念 在确定预防和治疗ADRD的有效战略方面。REC还将开发和交付 为本科生、研究生、研究员提供广泛的与ADRD相关的教育方案， 和来自其他学科的调查人员，通过ADRC进一步扩大新的调查人员渠道 与胡椒OAIC、CTSI和其他机构项目的互动。鉴于维克森林著名的 在老年人中进行大型多点临床研究的成功历史，是REC培训的重点 计划将包括团队科学，为新的调查人员提供确保项目成功的技能 管理、发展强大和可持续的协作，以及有效领导 多学科团队。这样的团队对于针对预防和治疗的科学发现将是必不可少的 ADRD的临床表现、病因和病理特征是不同的 弹道。

Research Education Component – Project Summary The Research Education Component will collaborate with other ADRC Cores and affiliate members to provide critical training and education to build a pipeline of new investigators from diverse backgrounds and with the necessary research interests and skills to meaningfully contribute to ADRD research – particularly with regard to metabolic and vascular risk factors underlying ADRD pathogenesis. In the last 4 years, we supported training of 20 graduate students and 8 postdoctoral fellows, and intensive mentoring for 17 junior faculty – 70% of whom now serve as Principal Investigators on 22 NIH or foundation ADRD grants. In the next cycle, REC programs will continue to leverage unique strengths and resources of the institution and the ADRC, particularly with regard to our experiences conducting ADRD translational research – from cellular mechanisms through rodent and nonhuman primate models to large-scale multi-site clinical studies. The REC Scholars Program will provide individualized and comprehensive training to junior investigators with clinical or basic science expertise to facilitate expansion of their work to support key concepts in translational science that could be instrumental in identifying effective strategies for ADRD prevention and treatment. The REC will also develop and deliver an extensive portfolio of ADRD-related educational programming for undergraduates, graduate students, fellows, and investigators from other disciplines to further expand the new investigator pipeline through ADRC interactions with Pepper OAIC, CTSI and other institutional programs. Given Wake Forest’s well-known and successful history conducting large multi-site clinical studies in older adults, a focus of the REC training program will include Team Science to provide new investigators with the skills to ensure successful project management, development of strong and sustainable collaborations, and effective leadership of multidisciplinary teams. Such teams will be essential for scientific discovery targeting prevention and treatment of ADRDs, which are characteristically heterogeneous in clinical presentation, etiology, and pathologic trajectory.