REC Core

研究教育部分-项目摘要 研究教育部分将与其他ADRC核心和附属成员合作， 关键的培训和教育，以建立一个管道的新的调查员来自不同的背景，并与 必要的研究兴趣和技能，为ADRD研究做出有意义的贡献-特别是在 ADRD发病机制的代谢和血管危险因素。在过去的四年里，我们支持 培训20名研究生和8名博士后研究员，并为17名初级教师提供密集指导- 70% 其中22人目前担任NIH或基金会ADRD赠款的主要研究者。在下一个周期，REC 计划将继续利用该机构和ADRC的独特优势和资源，特别是 关于我们进行ADRD转化研究的经验-从细胞机制到 啮齿动物和非人灵长类动物模型用于大规模多中心临床研究。REC学者计划将 为具有临床或基础科学专业知识的初级研究者提供个性化和全面的培训 促进其工作的扩展，以支持可能有助于转化科学的关键概念 确定ADRD预防和治疗的有效策略。REC还将开发和提供一个 为本科生、研究生、研究员提供广泛的ADRD相关教育计划， 以及其他学科的调查人员，通过ADRC进一步扩大新的调查人员渠道 与Pepper OAIC、CTSI和其他机构项目的互动。鉴于维克森林的知名度和 在老年人中进行大型多中心临床研究的成功历史，这是REC培训的重点 该计划将包括团队科学，为新的调查人员提供技能，以确保项目成功 管理，发展强大和可持续的合作，以及有效的领导， 多学科团队。这些小组对于针对预防和治疗的科学发现至关重要 在临床表现、病因学和病理学方面具有特征性异质性的ADRD 弹道

Research Education Component – Project Summary The Research Education Component will collaborate with other ADRC Cores and affiliate members to provide critical training and education to build a pipeline of new investigators from diverse backgrounds and with the necessary research interests and skills to meaningfully contribute to ADRD research – particularly with regard to metabolic and vascular risk factors underlying ADRD pathogenesis. In the last 4 years, we supported training of 20 graduate students and 8 postdoctoral fellows, and intensive mentoring for 17 junior faculty – 70% of whom now serve as Principal Investigators on 22 NIH or foundation ADRD grants. In the next cycle, REC programs will continue to leverage unique strengths and resources of the institution and the ADRC, particularly with regard to our experiences conducting ADRD translational research – from cellular mechanisms through rodent and nonhuman primate models to large-scale multi-site clinical studies. The REC Scholars Program will provide individualized and comprehensive training to junior investigators with clinical or basic science expertise to facilitate expansion of their work to support key concepts in translational science that could be instrumental in identifying effective strategies for ADRD prevention and treatment. The REC will also develop and deliver an extensive portfolio of ADRD-related educational programming for undergraduates, graduate students, fellows, and investigators from other disciplines to further expand the new investigator pipeline through ADRC interactions with Pepper OAIC, CTSI and other institutional programs. Given Wake Forest’s well-known and successful history conducting large multi-site clinical studies in older adults, a focus of the REC training program will include Team Science to provide new investigators with the skills to ensure successful project management, development of strong and sustainable collaborations, and effective leadership of multidisciplinary teams. Such teams will be essential for scientific discovery targeting prevention and treatment of ADRDs, which are characteristically heterogeneous in clinical presentation, etiology, and pathologic trajectory.