Mechanisms of actions(s) of simvastatin in uterine leiomyoma

辛伐他汀治疗子宫肌瘤的作用机制

• 批准号: 10432433
• 负责人: Mostafa A. Borahay
• 金额: $ 30万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10432433
• 关键词: Acute; Anxiety; Biopsy; CD8-Positive T-Lymphocytes; COVID-19; COVID-19 vaccination; COVID-19 vaccine; Cells; Clinical Trials; Complex; Data; Data Collection; Data Reporting; Distress; Endocrine system; Endometrial; Endometrial Stromal Cell; Endometrium; Extracellular Matrix; Extracellular Matrix Degradation; Funding; Goals; Health; Hemorrhage; Immune; Immune response; Immune system; Incidence; Inflammation; Inflammation Mediators; Injury; Irregular Menstruation; Lead; Leukocytes; Macrophage Activation; Matrix Metalloproteinases; Mediator of activation protein; Menstrual cycle; Menstruation; Neutrophil Infiltration; Participant; Pattern; Peptide Hydrolases; Personal Satisfaction; Physiological Processes; Play; Population Heterogeneity; Process; Registries; Reporting; Resolution; Role; Serum; Simvastatin; Spottings; T-Lymphocyte; Testing; Tissues; United States National Institutes of Health; Uterine Fibroids; Vaccination; Vaccines; Vascular System; chemokine; clinical effect; cohort; coronavirus disease; cytokine; diaries; digital; experience; extracellular; inflammatory marker; macrophage; neutrophil; peripheral blood; recruit; repaired; side effect; vaccine hesitancy; web site

PROJECT SUMMARY Regular menstruation is considered an indicator of whole-body health, and subtle changes in health can lead to noticeable fluctuations in the regular cycle. The large roll-out of COVID-19 vaccine was accompanied by anecdotal evidence that suggested that those who menstruate experienced changes in the menstrual cycle with some reporting unexpected spotting or heavier and/or longer cycles. Unfortunately, the initial clinical trials for the Pfizer, Moderna, and Johnson and Johnson vaccines did not follow up on possible menstrual cycle changes. The first aim of our project is to assess the clinical effects of the COVID-19 vaccination on the menstrual cycle using data from participants in our ongoing clinical trial who document their menstrual cycle using a menstrual diary. We will expand recruitment through a national, digital campaign: www.covidmenses.org. Data reported in the popular Period-Tracking App “Clue” will also be used to assess the clinical effects. The second aim will focus on the mechanisms of COVID-19 vaccines' effects on the menstrual cycle through assessing endometrial changes associated with vaccination. This will be done by comparing the immune cell profile at the level of the endometrium before and after vaccination as well as evaluating the expression of cytokines, chemokines and extracellular degradation mediators. The successful completion of this project will provide evidence on the effect of COVID-19 vaccination on menstrual health. This can reduce vaccine anxiety and hesitancy among those who menstruate.

项目摘要 月经规律被认为是全身健康的指标，健康的细微变化会导致 在正常的周期中有明显的波动。随着COVID-19疫苗的大规模推广， 轶事证据表明，那些月经周期发生变化的人， 一些报告了意外的斑点或更重和/或更长的循环。不幸的是，最初的临床试验 辉瑞、Moderna、约翰逊和约翰逊疫苗没有对可能的月经周期进行随访 变化 我们项目的第一个目的是评估COVID-19疫苗接种对月经周期的临床影响。 使用我们正在进行的临床试验中的参与者的数据，这些参与者使用 月经日记我们将通过一项全国性的数字宣传活动（www.covidmenses.org）扩大招聘。 流行的周期跟踪应用程序“Clue”中报告的数据也将用于评估临床效果。第二 目的将通过评估COVID-19疫苗对月经周期影响的机制， 与疫苗接种相关的子宫内膜变化。这将通过比较免疫细胞的分布来完成。 接种前后子宫内膜的水平以及评价细胞因子的表达， 趋化因子和细胞外降解介质。 该项目的成功完成将为COVID-19疫苗接种对 月经健康这可以减少接种疫苗的焦虑和犹豫。