Nicotine Withdrawal and Reward Processing: Connecting Neurobiology toReal-World Behavior

尼古丁戒断和奖励处理：将神经生物学与现实世界行为联系起来

• 批准号: 10439154
• 负责人: Jason Anthony Oliver
• 金额: $ 15.8万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10439154
• 关键词: Adult; Applied Research; Automobile Driving; Award; Basic Science; Behavior; Behavioral; Brain; Child; Cigarette Smoker; Clinical Trials; Cues; Data; Development; Disease; Ecological momentary assessment; Environment; Equilibrium; Evaluation; Frequencies; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Health; Image; Intervention; K-Series Research Career Programs; Laboratories; Laboratory Finding; Mentored Patient-Oriented Research Career Development Award; Mentors; Methodology; Methods; Modeling; Motivation; Neurobiology; Nicotine; Nicotine Dependence; Nicotine Withdrawal; Participant; Play; Procedures; Randomized; Research; Research Personnel; Research Project Grants; Restaurants; Rewards; Role; Satiation; Scientist; Smoke; Smoker; Smoking; Smoking Behavior; Smoking Cessation Intervention; Stimulus; Tobacco smoking behavior; Tobacco use; Training; Translational Research; Validation; Visit; Withdrawal; Work; addiction; brain behavior; career; career development; cigarette smoking; clinical development; clinical trial analysis; clinically relevant; design; experience; innovation; insight; interest; low nicotine content cigarette; mobile computing; neuroeconomics; neuroimaging; neuromechanism; nicotine reward; non-smoking; novel; novel strategies; patient oriented; pleasure; programs; public health relevance; relating to nervous system; response; reward processing; sex; skills; smoking cessation; theories; time use; training project; translational approach; translational impact; translational research program

PROJECT SUMMARY/ABSTRACT The goal of this K23 Mentored Patient-Oriented Research Career Development Award is to provide the candidate, Dr. Jason Oliver, with the training necessary to establish a career as an independent investigator conducting translational research on tobacco use and smoking cessation. Current understanding of the mechanisms responsible for driving smoking behavior is limited and existing smoking cessation treatments are modestly effective at best. The proposed training and research project center on a novel framework for understanding smoking behavior emphasizing the imbalance between rewards attainable through cigarette smoking relative to other non-smoking environmental rewards. The study will examine the effects of nicotine withdrawal on reward imbalances among 60 cigarette smokers. An innovative strategy will be used to systematically identify personally-relevant smoking and alternative rewards in order to enhance the salience of the rewards and increase the potential for findings to inform the development of clinical interventions. A translational approach will be used to assess reward responses in parallel inside the laboratory as well as outside the lab in real-time using mobile technology. In the first aim, we will examine the effects of nicotine withdrawal on neurobiological responses to images of personally-relevant smoking and non-smoking reward stimuli taken from the smoker’s natural environment using functional neuroimaging (fMRI). In the second aim, we will examine the effects of withdrawal on the frequency with which they engage in these behaviors and the magnitude of the reward response. The third aim will examine the relationship between laboratory and real- world responses. Results will enhance our understanding of the neural mechanisms of reward imbalances and the role these mechanisms play in driving smoking behavior. As part of the broader career development of the applicant, he will receive training from a team of well-established investigators with expertise related to the above topics. Dr. Adam Leventhal will provide conceptual training in the role of alternative rewards in smoking. Dr. Scott Huettel will provide conceptual training in neuroeconomics and methodological training in functional neuroimaging. Dr. Jean Beckham will provide methodological training in the assessment of real-world smoking behavior. Dr. Robert Schnoll will provide training in the design and analysis of clinical trials for smoking cessation. Dr. Joseph McClernon will guide overall professional and contribute to training in functional neuroimaging, smoking cessation clinical trials and the development of a translational research program more broadly. Ultimately, this K23 application will provide the candidate with the training and experience necessary to function as an independent research scientist conducting both basic and applied research on smoking behavior and successfully compete for R01 funding upon completion of the award.

项目总结/文摘

项目成果

Commentary on Kunas et al.: Hijacked brain reward systems-how methodological advances can help to bridge gaps in the translational science pipeline.

Kunas 等人的评论：被劫持的大脑奖励系统——方法论的进步如何帮助弥合转化科学管道中的差距。

• DOI: 10.1111/add.15678
• 发表时间: 2022
• 期刊: Addiction (Abingdon, England)
• 作者: Oliver,JasonA;Sweitzer,MaggieM
• 通讯作者: Sweitzer,MaggieM

Precision medicine in addiction research: where has the time gone?

成瘾研究中的精准医学：时间都去哪儿了？

• DOI: 10.1111/add.14023
• 发表时间: 2017
• 期刊: Addiction (Abingdon, England)
• 作者: Oliver,JasonA;McClernon,FJoseph
• 通讯作者: McClernon,FJoseph

What Do Smokers Want in A Smartphone-Based Cessation Application?

• DOI: 10.1093/ntr/ntx171
• 发表时间: 2018-12-01
• 期刊: NICOTINE & TOBACCO RESEARCH
• 影响因子: 4.7
• 作者: Oliver, Jason A.;Hallyburton, Matthew B.;McClernon, F. Joseph
• 通讯作者: McClernon, F. Joseph

Prediction of Smoking Risk From Repeated Sampling of Environmental Images: Model Validation.

• DOI: 10.2196/27875
• 发表时间: 2021-11-01
• 期刊: Journal of medical Internet research
• 影响因子: 7.4
• 作者: Engelhard MM;D'Arcy J;Oliver JA;Kozink R;McClernon FJ
• 通讯作者: McClernon FJ

Using Neuroscience to Inform Tobacco Control Policy.

• DOI: 10.1093/ntr/nty057
• 发表时间: 2019-05-21
• 期刊: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
• 作者: Maynard OM;McClernon FJ;Oliver JA;Munafò MR
• 通讯作者: Munafò MR