National Consortium on Alcohol and Neurodevelopment in Adolescence: San Diego

项目摘要 在年轻的成年期，饮酒量急剧增加，22岁时达到顶峰， 一半的人报告酗酒。长期饮酒期间频繁酗酒 25岁左右的神经成熟期可能比类似的酒精对大脑和认知的影响更大 在成年后期使用。作为对RFA-AA-17-003的回应，本申请提出了一个研究项目地点， 国家酒精和青少年神经发育联盟第二阶段（NCANDA-2）， 确定青少年在青春期和青年期大量饮酒的预测因素和影响。到 为了实现这一目标，UCSD的NCANDA-2站点将继续跟踪211个圣地亚哥地区的队列（n=831， 所有5个研究中心）参与者（基线访视时年龄为12-21岁），以获取必要的数据，以促进我们的理解 青少年发展的影响以及青少年时期饮酒对成年人大脑的影响。NCANDA-2将 使用多模式神经成像，认知测试，行为评估，生物标本收集，和多模式 在自然环境中进行评估。对酒精后果的审查将侧重于结构和 在青春期和青年期活跃发育的大脑区域的功能成熟， 在心理调节中，对奖励做出反应，并且似乎容易受到酒精的神经毒性影响。在 此外，UCSD研究中心将与杜克和OHSU研究中心合作，研究这些异常的恢复情况。 具体来说，我们将研究有针对性的大量饮酒与神经认知和大脑相关的程度。 完整性缺陷免除超过4周的监测禁欲。UCSD还将与SRI网站合作， 在fMRI环境中收集Stroop任务，以评估青少年认知控制系统的变化 与不喝酒的人相比发展中的性别差异，酒精使用模式和 历史，酒精使用对大脑的影响，以及性别差异的心理社会因素（例如，抑郁 症状）将在分析中考虑。通过此次更新提供的额外纵向数据，我们将 确定酒精暴露对青少年大脑发育轨迹的影响， 确定可能改变青少年和年轻人的心理生物学脆弱性和不确定性， 酒精或其他物质使用障碍和其他心理健康和发育结果的风险。

PROJECT SUMMARY During young adulthood, drinking dramatically increases, with binge-level drinking peaking at age 22 and nearly half of individuals reporting binge-level alcohol use. Frequent binge alcohol use during the protracted neuromaturation spanning into the mid-20s may result in greater brain and cognitive effects than similar alcohol use in later adulthood. In response to RFA-AA-17-003, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence second phase (NCANDA-2) to determine the predictors and effects of heavy adolescent alcohol use in adolescence and young adulthood. To achieve this, the UCSD site of NCANDA-2 will continue to follow a cohort of 211 San Diego-area (n=831 across all 5 sites) participants (ages 12-21 at baseline visit) to acquire the necessary data to advance our understanding of adolescent development and the effects of alcohol use during adolescence on the adult brain. NCANDA-2 will use multimodal neuroimaging, cognitive testing, behavioral assessment, biospecimen collection, and multimodal assessments in the natural environment. The examination of alcohol consequences will focus on structural and functional maturation of brain areas that actively develop during adolescence and young adulthood, are involved in psychological regulation, respond to rewards, and appear vulnerable to neurotoxic effects of alcohol. In addition, the UCSD site will collaborate with the Duke and OHSU sites to study recovery of these abnormalities. Specifically, we will examine the degree to which targeted heavy drinking related neurocognitive and brain integrity deficits remit over 4 weeks of monitored abstinence. UCSD will also collaborate with the SRI site to collect the Stroop task in the fMRI environment to evaluate changes in the cognitive control system for youth who increase drinking versus those who do not. Sex differences in development, alcohol use patterns and history, impact of alcohol use on the brain, and sex-differentiating psychosocial factors (e.g., depression symptoms) will be considered in analyses. With the additional longitudinal data provided by this renewal, we will determine the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities and resiliencies that may alter adolescents’ and young adults’ risk for alcohol or other substance use disorder and other mental health and developmental outcomes.