Acquisition of a Surface Plasmon Resonance Instrument

项目总结/摘要 波士顿大学化学系寻求NIH的支持，以获得Cytiva Biacore S200表面等离子体共振（SPR）仪器满足生物物理学的关键需求 特征化所要求的仪器将取代一个>15岁的模型， 变得无法修复它将使CRC的研究人员能够推进他们的研究 在生命过程中（化学，生物学，生物化学和生物医学工程），将允许他们 研究将进入新的领域，并将丰富学生和博士后培训。的 所请求的仪器对8个主要用户的研究计划至关重要（艾伦教授， Beeler，Galagan，Harris，Ngo，Schaus，Vegas和Whitty）和5个次要用户（教授，Brown， Perlstein，Porco，Vajda和Wong）跨越五个学术部门。请求的 仪器将恢复这些研究人员在研究中使用SPR的能力， 我们的生物物理表征能力，以满足当前和不断发展的研究需求， 教师和学生，并提供新的能力，以支持小分子配体的发现。 因此，SPR仪器将在BU扩大其生命科学研究方面发挥关键作用。 大学的承诺是通过其在基础设施的支持， 多用户研究工具，并提供全职技术支持人员的工资。 2005年，BU完成了5，500平方米的建设，英尺化学仪表中心（CIC）， 其设计有特定的空间和指定的支持人员，用于台式光学 仪器仪表议会总监李国麟博士将负责管理 要求的仪器，和CIC工作人员斯蒂芬惠兰博士将操作和维护 工具并提供用户培训。中投公司有一个示范管理计划， 仪器的使用，财务监督和科学监督，包括一个九人 由用户和非用户代表组成的咨询委员会。研究生和 用户实验室的博士后研究员将广泛使用该仪器， 他们的研究。对青年科学家的这种培训将有助于他们实现研究目标， 为他们提供更多的技能，使他们在未来的职业生涯中取得成功。

Project Summary/Abstract The Boston University Department of Chemistry seeks NIH support to acquire a Cytiva Biacore S200 Surface Plasmon Resonance (SPR) instrument to address a critical need for biophysical characterization. The requested instrument will replace a >15-year-old model that recently became irreparably inoperable. It will enable investigators on the CRC to advance their research in life processes (chemistry, biology, biochemistry and biomedical engineering), will allow their investigations to move into new areas, and will enrich student and postdoctoral training. The requested instrument is critical to the research programs of 8 Major Users (Professors Allen, Beeler, Galagan, Harris, Ngo, Schaus, Vegas, and Whitty) and 5 Minor Users (Professors, Brown, Perlstein, Porco, Vajda, and Wong) spanning five academic departments. The requested instrument will restore the ability of these investigators to use SPR in their research, enhancing our biophysical characterization capability to meet the current and evolving research needs of the faculty and students, and provide new capabilities to support small molecule ligand discovery. The SPR instrument will thus play a pivotal role in BU’s expansion of its life science research. The University’s commitment is demonstrated by its investment in the infrastructure for supporting multi-user research instruments, and by its provision of salary for full time technical support staff. In 2005, BU completed construction of the 5,500 sq.-ft. Chemical Instrumentation Center (CIC), which was designed with specific space and support staff designated for bench-top optical instrumentation. The CIC’s Director, Dr. Norman Lee, will manage the usage and finances of the requested instrument, and the CIC Staff Dr. Stephen Whelan will operate and maintain the instrument and provide user training. The CIC has a demonstrated management plan for the instrument’s usage, financial supervision, and scientific oversight, including a nine-member Advisory Committee with representatives from users and non-users. The graduate students and postdoctoral fellows in the laboratories of the users will use this instrument extensively as part of their research. This training of young scientists will facilitate their research objectives, while providing them with additional technical skills for succeeding in their future professional careers.