Acquisition of a Surface Plasmon Resonance Instrument

项目摘要/摘要 波士顿大学化学系寻求NIH支持收购Cytiva Biacore S200表面等离子体共振(SPR)仪器解决生物物理的关键需求 人物刻画。所要求的仪器将取代已有15年历史的型号，该型号最近 变得无可挽回地无法动手术。它将使儿童权利中心的调查人员能够推进他们的研究 在生命过程中(化学、生物、生物化学和生物医学工程)，将允许他们 调查将进入新的领域，并将丰富学生和博士后培训。这个 所要求的仪器对8个主要用户的研究计划至关重要(Allen教授， Beeler、Galagan、Harris、Ngo、Schaus、拉斯维加斯和Whitty)和5个未成年用户(Brown教授、 Perlstein、Porco、Vajda和Wong)，横跨五个学术部门。所请求的 仪器将恢复这些研究人员在他们的研究中使用SPR的能力，增强 我们的生物物理表征能力，以满足当前和不断发展的研究需求 并提供新的能力来支持小分子配体的发现。 因此，SPR仪器将在北京大学扩大其生命科学研究方面发挥关键作用。 大学的承诺体现在对基础设施的投资上，以支持 多用户研究仪器，并为全职技术支持人员提供薪金。 2005年，BU完成了5500平方英尺的建设。化学仪器中心(CIC) 它是为台式光学设备指定的特定空间和支持人员设计的 仪器仪表。中国投资公司董事李诺曼博士将管理该基金的使用和财务 要求的仪器，CIC工作人员斯蒂芬·惠兰博士将操作和维护 仪器和提供用户培训。中投公司有一个示范的管理计划 工具的使用、金融监管和科学监督，包括一个九人小组 咨询委员会，由用户和非用户的代表组成。研究生们和 用户实验室的博士后研究员将广泛使用该仪器作为 他们的研究。这种对青年科学家的培训将促进他们的研究目标，同时 为他们在未来的职业生涯中取得成功提供额外的技术技能。

Project Summary/Abstract The Boston University Department of Chemistry seeks NIH support to acquire a Cytiva Biacore S200 Surface Plasmon Resonance (SPR) instrument to address a critical need for biophysical characterization. The requested instrument will replace a >15-year-old model that recently became irreparably inoperable. It will enable investigators on the CRC to advance their research in life processes (chemistry, biology, biochemistry and biomedical engineering), will allow their investigations to move into new areas, and will enrich student and postdoctoral training. The requested instrument is critical to the research programs of 8 Major Users (Professors Allen, Beeler, Galagan, Harris, Ngo, Schaus, Vegas, and Whitty) and 5 Minor Users (Professors, Brown, Perlstein, Porco, Vajda, and Wong) spanning five academic departments. The requested instrument will restore the ability of these investigators to use SPR in their research, enhancing our biophysical characterization capability to meet the current and evolving research needs of the faculty and students, and provide new capabilities to support small molecule ligand discovery. The SPR instrument will thus play a pivotal role in BU’s expansion of its life science research. The University’s commitment is demonstrated by its investment in the infrastructure for supporting multi-user research instruments, and by its provision of salary for full time technical support staff. In 2005, BU completed construction of the 5,500 sq.-ft. Chemical Instrumentation Center (CIC), which was designed with specific space and support staff designated for bench-top optical instrumentation. The CIC’s Director, Dr. Norman Lee, will manage the usage and finances of the requested instrument, and the CIC Staff Dr. Stephen Whelan will operate and maintain the instrument and provide user training. The CIC has a demonstrated management plan for the instrument’s usage, financial supervision, and scientific oversight, including a nine-member Advisory Committee with representatives from users and non-users. The graduate students and postdoctoral fellows in the laboratories of the users will use this instrument extensively as part of their research. This training of young scientists will facilitate their research objectives, while providing them with additional technical skills for succeeding in their future professional careers.