Leica Stellaris 8 Confocal Microscope
Leica Stellaris 8 Confocal Microscope
批准号:
10431426
负责人:
HANS-WILLEM E SNOECK
金额:
$65.16万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
已结题
起止时间:
2022-06-01 至 2023-05-31
中文摘要
传统的共聚焦显微镜是一个强大的工具,特殊的时间细胞和组织
英文摘要
Conventional confocal microscopy is a powerful tool for special-temporal cellular and tissue
imaging, typically with up to four fluorophores. Recently, there has been an increasing demand
for multiplex, high-resolution analysis. However, with most currently available microscopes it is
technically impossible to detect fluorophores in the near-infrared (NIR) range, thus limiting the
multiplexing capability. The enhanced detection is required not only for detection in the near-
infrared (NIR), but also because this allows the use of directly conjugated antibodies when the
choice of species in which any primary antibodies were generated is limited. Establishing a user-
friendly multiplex imaging system to complement genome-wide, next-generation sequencing
analysis is an unmet need. An additional limitation of conventional confocal microscopy is its
resolution. Several recently developed confocal scanning microscopes are beginning to meet this
need by combining superior detectors and advanced computational deconvolution to enhance
both multiplexing options and resolution. Both multiplexing capability and resolution are
particularly imperative for the major users on this proposal who focus on developmental and stem
cell biology to deepen our understanding of human disease and develop innovative treatments.
We therefore propose to acquire a Leica Stellaris 8 microscope that allows multiplexing by
providing excitation and enhanced detection in the NIR, as well as computational super-
resolution.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Lung epithelial cell specification in human pluripotent stem cells
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批准号:10378129
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项目类别:
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资助金额:$56.79万
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财政年份:2019
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Lung epithelial cell specification in human pluripotent stem cells
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批准号:9902521
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项目类别:
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资助金额:$56.79万
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财政年份:2019
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Mitochondrial Maintenance Mechanisms of Stem Cells and Aging
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批准号:9751137
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资助金额:$38.87万
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财政年份:2017
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Mitochondrial Regulation of Hematopoietic Stem Cells
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批准号:10551891
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资助金额:$67.57万
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财政年份:2017
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Mitochondrial Maintenance Mechanisms of Stem Cells and Aging
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批准号:10192621
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项目类别:
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资助金额:$38.87万
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财政年份:2017
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Mitochondrial Regulation of Hematopoietic Stem Cells
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批准号:10375950
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项目类别:
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资助金额:$68.96万
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财政年份:2017
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Mitochondrial regulation of hematopoietic stem cells
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批准号:9218717
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资助金额:$45.02万
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财政年份:2017
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Modeling, pathogenesis and treatment of idiopathic pulmonary fibrosis
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批准号:9516638
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项目类别:
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资助金额:$27.2万
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财政年份:2016
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Modeling, pathogenesis and treatment of idiopathic pulmonary fibrosis
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批准号:9509525
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项目类别:
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资助金额:$126.1万
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财政年份:2016
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Modeling, pathogenesis and treatment of idiopathic pulmonary fibrosis
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批准号:10192798
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项目类别:
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资助金额:$126.42万
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财政年份:2016
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Modeling, pathogenesis and treatment of idiopathic pulmonary fibrosis
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批准号:9355205
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项目类别:
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资助金额:$95.54万
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财政年份:2016
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Modeling, pathogenesis and treatment of idiopathic pulmonary fibrosis
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批准号:10416013
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项目类别:
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资助金额:$126.3万
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财政年份:2016
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负责人:HANS-WILLEM E SNOECK
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依托单位:
BD Biosciences Influx
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批准号:8826484
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项目类别:
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资助金额:$60.0万
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财政年份:2015
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Bioengineering a Chimeric Human Lung
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批准号:8573460
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项目类别:
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资助金额:$52.23万
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财政年份:2013
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Bioengineering a Chimeric Human Lung
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批准号:8722023
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项目类别:
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资助金额:$53.64万
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财政年份:2013
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Bioengineering a Chimeric Human Lung
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批准号:8854137
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项目类别:
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资助金额:$53.84万
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财政年份:2013
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Mechanism of action of Prdm16 in hematopoietic stem cells
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批准号:8776279
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项目类别:
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资助金额:$33.2万
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财政年份:2013
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Mechanism of action of Prdm16 in hematopoietic stem cells
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批准号:9188766
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项目类别:
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资助金额:$33.2万
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财政年份:2013
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Bioengineering a Chimeric Human Lung
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批准号:9067487
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项目类别:
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资助金额:$54.6万
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财政年份:2013
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负责人:HANS-WILLEM E SNOECK
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依托单位:
Bioengineering a chimeric human lung
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批准号:10219817
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项目类别:
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资助金额:$84.24万
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财政年份:2013
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负责人:HANS-WILLEM E SNOECK
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依托单位:
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批准号:--
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批准年份:2022
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依托单位: