Sabor que Sana: Evaluation of a Traditional Mexican Dietary Pattern and NAFLD Risk in Mexican-origin Hispanic Adults

Sabor que Sana：墨西哥裔西班牙裔成年人传统墨西哥饮食模式和 NAFLD 风险的评估

• 批准号: 10431809
• 负责人: Melissa Lopez Pentecost
• 金额: $ 3.92万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10431809
• 关键词: Address; Adherence; Adult; Affect; Attitude; Award; Behavior; Behavior Therapy; Behavioral; Belief; Biometry; Biostatistics Shared Resource; Body mass index; Cancer Control Research; Cancer Survivor; Centers for Disease Control and Prevention (U.S.); Child Care; Clinical Trials; Data; Data Set; Development; Diet; Dietary Intervention; Dietary Practices; Eating; Epidemiology; Ethnic group; Evaluation; Fatty Liver; Funding; Future; Goals; Grant; Health; Health Technology; Healthy Eating; Hispanic; Hispanic Populations; Incidence; Infrastructure; Intervention; Intervention Studies; Interview; Investigation; Knowledge; Life Style; Literature; Liver; Liver Fibrosis; Malignant Neoplasms; Metabolic dysfunction; Mexican; Mobile Health Application; Modality; Modification; National Institute on Minority Health and Health Disparities; Nutritional; Obesity; Obesity associated cancer; Observational Study; Overweight; Participant; Pattern; Persons; Population; Population Heterogeneity; Positioning Attribute; Postmenopause; Prevention; Primary carcinoma of the liver cells; Public Health; Publications; Qualitative Research; Reducing diet; Reporting; Research; Research Methodology; Research Personnel; Resources; Risk Factors; Role; Sampling; Schedule; Science; Statistical Data Interpretation; Structure; Subgroup; Telephone; Text Messaging; Training; Transportation; Underrepresented Populations; United States; Woman; Work; Writing; behavior change; behavior influence; burden of illness; cancer epidemiology; cancer prevention; career; career development; cohort; data de-identification; design; dietary; disorder risk; experience; health disparity; high risk; high risk population; improved; insight; intervention delivery; mHealth; meetings; men; mortality; mortality risk; non-alcoholic fatty liver disease; nutrition related genetics; nutritional epidemiology; patient engagement; prevent; programs; racial and ethnic; sex; skills; statistics; success; trial design; ultrasound

PROJECT SUMMARY The incidence of non-alcoholic fatty liver disease (NAFLD), a known risk factor for hepatocellular carcinoma (HCC), is on the rise and disproportionately affecting the health of the Mexican-origin (MO) Hispanic population. Lifestyle behaviors which promote healthy eating patterns are the cornerstone prevention and treatment for NAFLD. Yet, epidemiological evidence evaluating dietary patterns, including those consistent with a traditional Mexican diet, are lacking. Recent analysis of these relationships in postmenopausal Hispanic women support a potential beneficial role in cancer mortality risk, which warrants further investigation in additional datasets and advancements using formative research to develop feasible, acceptable and impactful dietary interventions for NAFLD treatment among MO adults. Further, intervention studies in MO adults has identified barriers for participant engagement, including transportation, work schedules, and childcare. To build the epidemiological and intervention evidence related to diet and NAFLD risk in MO Hispanics, and answer the research question of whether effective dietary interventions can be developed and implemented to reduce the burden of this disease in the MO Hispanic population, two specific aims will be completed leveraging 1) pre-existing, de-identified data, from the Liver Ultrasound Nutrigenetic Assessment (LUNA) study in MO adults; and 2) LUNA study resources and infrastructure, including a subsample of participants to conduct qualitative work focused on knowledge, attitudes and beliefs of a traditional Mexican diet pattern and intervention delivery modalities, such as mobile health (mHealth) technology. Importantly, there is an opportunity to engage in formative research work under Dr. Garcia's (Co-sponsor) NIMHD-funded K01 and semi-structured interviews with Hispanic cancer survivors as part of Dr. Thomson's (Sponsor) role in the CDC-funded, national Cancer Prevention and Control Research Network. The proposed research aims are: 1) to examine the relationship between the traditional Mexican diet score and liver steatosis and fibrosis (NAFLD) and evaluate effect modification by sex and body mass index among 285 MO adults from the LUNA study, and 2) utilize formative research methods among MO adults participating in the LUNA study to design and develop an mHealth pilot feasibility traditional Mexican diet intervention. These research aims will address gaps in Ms. Lopez-Pentecost's training by 1) developing a highly informed and robust knowledge and skills in the field of nutritional cancer epidemiology with a focus on diverse populations, 2) gaining knowledge in formative, qualitative research that informs on the development of quality behavioral intervention trial designs, including mHealth applications, and 3) increasing scientific publication and presentations, as well as grant writing skills contributing to career development. With this award, the sponsoring team, and available institutional resources, Ms. Lopez-Pentecost is well positioned to complete this project and take an incremental step towards achieving her goal of establishing a career as a behavioral researcher in cancer prevention science, focused on underrepresented populations.

项目总结

项目成果

Factors associated with cancer treatment delay: a protocol for a systematic review and meta-analysis.

• DOI: 10.1136/bmjopen-2022-061121
• 发表时间: 2022-06-28
• 期刊: BMJ OPEN
• 影响因子: 2.9
• 作者: Morrill, Kristin E.;Robles-Morales, Rogelio;Lopez-Pentecost, Melissa;Martinez Portilla, Raigam J.;Saleh, Ahlam A.;Skiba, Meghan B.;Riall, Taylor S.;Austin, Jessica D.;Hirschey, Rachel;Jacobs, Elizabeth T.;Spotleson, Lena;Hanna, Timothy P.
• 通讯作者: Hanna, Timothy P.

Health Promotion Among Mexican-Origin Survivors of Breast Cancer and Caregivers Living in the United States-Mexico Border Region: Qualitative Analysis From the Vida Plena Study.

• DOI: 10.2196/33083
• 发表时间: 2022-02-24
• 期刊: JMIR cancer
• 影响因子: 2.8
• 作者: Skiba MB;Lopez-Pentecost M;Werts SJ;Ingram M;Vogel RM;Enriquez T;Garcia L;Thomson CA
• 通讯作者: Thomson CA