Sabor que Sana: Evaluation of a Traditional Mexican Dietary Pattern and NAFLD Risk in Mexican-origin Hispanic Adults

Sabor que Sana：墨西哥裔西班牙裔成年人传统墨西哥饮食模式和 NAFLD 风险的评估

• 批准号: 10431809
• 负责人: Melissa Lopez Pentecost
• 金额: $ 3.92万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10431809
• 关键词: Address; Adherence; Adult; Affect; Attitude; Award; Behavior; Behavior Therapy; Behavioral; Belief; Biometry; Biostatistics Shared Resource; Body mass index; Cancer Control Research; Cancer Survivor; Centers for Disease Control and Prevention (U.S.); Child Care; Clinical Trials; Data; Data Set; Development; Diet; Dietary Intervention; Dietary Practices; Eating; Epidemiology; Ethnic group; Evaluation; Fatty Liver; Funding; Future; Goals; Grant; Health; Health Technology; Healthy Eating; Hispanic; Hispanic Populations; Incidence; Infrastructure; Intervention; Intervention Studies; Interview; Investigation; Knowledge; Life Style; Literature; Liver; Liver Fibrosis; Malignant Neoplasms; Metabolic dysfunction; Mexican; Mobile Health Application; Modality; Modification; National Institute on Minority Health and Health Disparities; Nutritional; Obesity; Obesity associated cancer; Observational Study; Overweight; Participant; Pattern; Persons; Population; Population Heterogeneity; Positioning Attribute; Postmenopause; Prevention; Primary carcinoma of the liver cells; Public Health; Publications; Qualitative Research; Reducing diet; Reporting; Research; Research Methodology; Research Personnel; Resources; Risk Factors; Role; Sampling; Schedule; Science; Statistical Data Interpretation; Structure; Subgroup; Telephone; Text Messaging; Training; Transportation; Underrepresented Populations; United States; Woman; Work; Writing; behavior change; behavior influence; burden of illness; cancer epidemiology; cancer prevention; career; career development; cohort; data de-identification; design; dietary; disorder risk; experience; health disparity; high risk; high risk population; improved; insight; intervention delivery; mHealth; meetings; men; mortality; mortality risk; non-alcoholic fatty liver disease; nutrition related genetics; nutritional epidemiology; patient engagement; prevent; programs; racial and ethnic; sex; skills; statistics; success; trial design; ultrasound

PROJECT SUMMARY The incidence of non-alcoholic fatty liver disease (NAFLD), a known risk factor for hepatocellular carcinoma (HCC), is on the rise and disproportionately affecting the health of the Mexican-origin (MO) Hispanic population. Lifestyle behaviors which promote healthy eating patterns are the cornerstone prevention and treatment for NAFLD. Yet, epidemiological evidence evaluating dietary patterns, including those consistent with a traditional Mexican diet, are lacking. Recent analysis of these relationships in postmenopausal Hispanic women support a potential beneficial role in cancer mortality risk, which warrants further investigation in additional datasets and advancements using formative research to develop feasible, acceptable and impactful dietary interventions for NAFLD treatment among MO adults. Further, intervention studies in MO adults has identified barriers for participant engagement, including transportation, work schedules, and childcare. To build the epidemiological and intervention evidence related to diet and NAFLD risk in MO Hispanics, and answer the research question of whether effective dietary interventions can be developed and implemented to reduce the burden of this disease in the MO Hispanic population, two specific aims will be completed leveraging 1) pre-existing, de-identified data, from the Liver Ultrasound Nutrigenetic Assessment (LUNA) study in MO adults; and 2) LUNA study resources and infrastructure, including a subsample of participants to conduct qualitative work focused on knowledge, attitudes and beliefs of a traditional Mexican diet pattern and intervention delivery modalities, such as mobile health (mHealth) technology. Importantly, there is an opportunity to engage in formative research work under Dr. Garcia's (Co-sponsor) NIMHD-funded K01 and semi-structured interviews with Hispanic cancer survivors as part of Dr. Thomson's (Sponsor) role in the CDC-funded, national Cancer Prevention and Control Research Network. The proposed research aims are: 1) to examine the relationship between the traditional Mexican diet score and liver steatosis and fibrosis (NAFLD) and evaluate effect modification by sex and body mass index among 285 MO adults from the LUNA study, and 2) utilize formative research methods among MO adults participating in the LUNA study to design and develop an mHealth pilot feasibility traditional Mexican diet intervention. These research aims will address gaps in Ms. Lopez-Pentecost's training by 1) developing a highly informed and robust knowledge and skills in the field of nutritional cancer epidemiology with a focus on diverse populations, 2) gaining knowledge in formative, qualitative research that informs on the development of quality behavioral intervention trial designs, including mHealth applications, and 3) increasing scientific publication and presentations, as well as grant writing skills contributing to career development. With this award, the sponsoring team, and available institutional resources, Ms. Lopez-Pentecost is well positioned to complete this project and take an incremental step towards achieving her goal of establishing a career as a behavioral researcher in cancer prevention science, focused on underrepresented populations.

项目摘要 非酒精性脂肪性肝病（NAFLD）的发病率，这是肝细胞癌的已知风险因素 (HCC)这种情况正在上升，并不成比例地影响墨西哥裔西班牙裔人口的健康。 促进健康饮食模式的生活方式行为是预防和治疗 NAFLD。然而，评估饮食模式的流行病学证据，包括那些符合传统饮食模式的证据， 墨西哥人的饮食缺乏。最近对绝经后西班牙裔妇女中这些关系的分析支持 在癌症死亡风险中的潜在有益作用，这需要在其他数据集中进行进一步研究， 利用形成性研究开发可行的、可接受的和有效的饮食干预措施， MO成人中的NAFLD治疗。此外，对MO成人的干预研究已经确定了 参与者的参与，包括交通，工作时间表和儿童保育。为了建立流行病学 以及与MO西班牙裔饮食和NAFLD风险相关的干预证据，并回答以下研究问题 是否可以制定和实施有效的饮食干预措施，以减少这种疾病的负担 在MO西班牙裔人群中，将利用1）预先存在的、去识别的数据完成两个具体目标， MO成人肝脏超声营养遗传学评估（LUNA）研究; 2）LUNA研究资源 和基础设施，包括参与者的子样本，以开展以知识为重点的定性工作， 对传统墨西哥饮食模式和干预提供方式的态度和信念，例如移动的 健康（mHealth）技术。重要的是，有机会在博士的指导下从事形成性研究工作。 加西亚（共同赞助者）NIMHD资助的K 01和西班牙裔癌症幸存者的半结构化访谈， Thomson博士（赞助者）在CDC资助的国家癌症预防和控制研究网络中的作用。 建议的研究目的是：1）检查传统墨西哥饮食评分与 肝脂肪变性和纤维化（NAFLD），并通过性别和体重指数评估285例 来自LUNA研究的MO成年人，以及2）在参与研究的MO成年人中使用形成性研究方法。 LUNA研究设计和开发移动健康试点可行性传统墨西哥饮食干预.这些 研究目标将通过以下方式解决洛佩兹-五旬节女士培训中的差距：1）开发一个高度知情和强大的 营养癌症流行病学领域的知识和技能，重点是不同人群，2）获得 形成性定性研究的知识，为质量行为干预的发展提供信息 试验设计，包括mHealth应用程序，以及3）增加科学出版物和演示文稿，以及 作为赠款写作技能有助于职业发展。有了这个奖项，赞助团队，并提供 机构资源，洛佩兹-Pentecost女士完全有能力完成这个项目，并采取增量 朝着她在癌症预防科学中建立行为研究员职业生涯的目标迈出了一步， 关注代表性不足的人群。

项目成果

Factors associated with cancer treatment delay: a protocol for a systematic review and meta-analysis.

• DOI: 10.1136/bmjopen-2022-061121
• 发表时间: 2022-06-28
• 期刊: BMJ OPEN
• 影响因子: 2.9
• 作者: Morrill, Kristin E.;Robles-Morales, Rogelio;Lopez-Pentecost, Melissa;Martinez Portilla, Raigam J.;Saleh, Ahlam A.;Skiba, Meghan B.;Riall, Taylor S.;Austin, Jessica D.;Hirschey, Rachel;Jacobs, Elizabeth T.;Spotleson, Lena;Hanna, Timothy P.
• 通讯作者: Hanna, Timothy P.

Health Promotion Among Mexican-Origin Survivors of Breast Cancer and Caregivers Living in the United States-Mexico Border Region: Qualitative Analysis From the Vida Plena Study.

• DOI: 10.2196/33083
• 发表时间: 2022-02-24
• 期刊: JMIR cancer
• 影响因子: 2.8
• 作者: Skiba MB;Lopez-Pentecost M;Werts SJ;Ingram M;Vogel RM;Enriquez T;Garcia L;Thomson CA
• 通讯作者: Thomson CA