Administrative Core: IDEAL shapes vaccine response, susceptibility to respiratory infectious disease and asthma

项目总结：理想的行政核心 我们的总体方案将调查早期生命(理想)的免疫发育，以确定理想的内型。 与儿童时期的关键临床结果相对应，包括疫苗反应、呼吸道感染 疾病和哮喘。我们将通过以下三项不同但综合的研究来实现这一目标 通过尖端的硅胶技术(项目1，PR1)、表观遗传学(PR2)和体外培养(PR3)的互补方法 研究项目。鉴于拟议工作的科学范围、复杂性和地理范围， 研究理想的行政核心(AC)对于优化建议的质量和影响至关重要 进行研究，并确保及时提供预计交付成果。理想-AC的目标是建立 简化流程，促进每个理想项目的研究人员之间的高效互动 和科尔。我们将通过追求以下具体目标(SA)来实现这一目标： SA1.为行政领导提供基础设施，旨在建立互动和 协同工作团队，最大限度地发挥项目协同效应。 SA2.促进和促进项目和核心领导之间的沟通和互动 通过定期举行电话会议/面对面会议、年度会议以及 研讨会/专题讨论会的重点是理想项目。 SA3.管理和优化我们理想团队内部以及我们团队之间的沟通 其他国家卫生研究院支持理想团队和理想指导委员会。 SA4.通过以下方式解决可能在理想项目内部和外部出现的潜在冲突 执行冲突解决小组(CRG)的建议。 SA5.提供财政、监管和科学监督，审查和巩固年度进展 报告被送到了国家卫生研究院。 SA6.保护我们调查人员的知识产权，执行材料转让 协议。 SA7.在我们内部和外部的调查人员之间实施数据管理/共享计划 理想的团队。 总体而言，理想的AC将确保NIH资金的适当管理，并保持对 项目时间表，所有这些都是为了优化和放大拟议研究的科学影响。

PROJECT SUMMARY: IDEAL Administrative Core Our overall proposal will investigate immune development in early life (IDEAL) to identify IDEAL endotypes that correspond to key clinical outcomes in childhood, including vaccine response, respiratory infectious disease and asthma. We will accomplish this goal through three distinct yet integrated studies that follow complementary approaches via cutting-edge in silico (project 1, PR1), epigenetic (PR2), and in vitro (PR3) research projects. Given the scientific scope, complexity, and geographic range of the proposed work, the study IDEAL Administrative Core (AC) will be crucial to optimize the quality and impact of the proposed studies and to ensure timely provision of projected deliverables. The goal of the IDEAL-AC is to institute streamlined processes which facilitate productive interactions among investigators from each IDEAL Project and Core. We will achieve this goal by pursuing the following Specific Aims (SAs): SA1. Provide infrastructure for administrative leadership aimed at building an interactive and collaborative working team resulting in maximal project synergy. SA2. Facilitate and promote communication and interactions amongst the Project and Core Leads by conducting regular teleconferences/face-to-face meetings, annual meetings, as well as seminars/symposia focused on the IDEAL project. SA3. Manage and optimize communication within our IDEAL team and between our team, the other NIH supported IDEAL teams and the IDEAL Steering Committee. SA4. Resolve potential conflicts that might arise within and outside of our IDEAL project by implementing recommendations of the Conflicts Resolution Group (CRG). SA5. Provide fiscal, regulatory and scientific oversight, review and consolidate yearly progress reports sent to the NIH. SA6. Protect intellectual property rights of our investigators and execute material transfer agreements. SA7. Implement the data management/sharing plan among investigators within and outside of our IDEAL team. Overall, the IDEAL AC will ensure appropriate stewardship of NIH funds and maintain adherence to project timelines, all with the goal to optimize and amplify the scientific impact of the proposed studies.