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COVID_Breastfeeding with COVID 19 disease: SARS-CoV-2 antibodies in breast milk and disease progression in the first six months of life

COVID_Breastfeeding with COVID 19 disease: SARS-CoV-2 antibodies in breast milk and disease progression in the first six months of life
COVID_患有 COVID 19 疾病的母乳喂养:母乳中的 SARS-CoV-2 抗体和生命前六个月的疾病进展
批准号:
10434947
负责人:
Sahira Askari Long
金额:
$21.15万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-06-18 至 2024-05-31

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中文摘要
翻译
摘要 目前尚不清楚新冠肺炎阳性的母亲是否会在体内传播SARS-CoV-2抗体 母乳来保护他们的新生儿,或者如果母乳喂养会造成感染的风险(或者 通过摄入病毒或在喂养期间与母亲直接接触)。科学家 假设(1)这些母亲的母乳可能具有SARS-CoV-2中和作用 可能提供保护的抗体;或(2)其母乳可能构成感染风险,如果 病毒从母乳中排出,并被婴儿消耗。到目前为止,可用的数据有限 支持这两个假设中的任何一个。因此,与SARS-CoV-2相关的母乳喂养建议 来自世界卫生组织(WHO)、疾病控制和预防中心(CDC) 和美国儿科学会(AAP)不同。然而,此前的研究表明, 在生命早期饮用母乳可使人对多种传染病产生免疫力。 任何指南的循证建议都需要研究和临床研究。 这项研究的目标是解决这一差距,并确定母乳摄入量是否可以 授予豁免权。这些目标将通过以下具体目标实现。 具体目标1.检测和定量存在的SARS-CoV-2 IgM/Ig G/Ig A抗体 超过6个月的母亲/婴儿的母乳和唾液中。 特定目标2.检测母乳和唾液中是否存在中和抗体 来自母婴双亲的样本。 具体目标3.确定是否以及如何消费新冠肺炎中的母乳 母亲SARS-CoV-2阳性影响SARS-CoV-2感染、进展和可能的复发 他们的孩子。
英文摘要
ABSTRACT It is unknown whether COVID-19 positive mothers transmit SARS-CoV-2 antibodies in their breast milk to protect their newborns or if breastfeeding can pose a risk of infection (either through consumption of virus or direct contact with the mother during feedings). Scientists hypothesize that (1) the breast milk of these mothers may have SARS-CoV-2 neutralizing antibodies which may confer protection; or (2) their breast milk can pose a risk of infection if the virus is shed in breast milk and consumed by the infant. Limited data are available thus far to support either hypothesis. As a result, SARS-CoV-2 related breastfeeding recommendations from the World Health Organization (WHO), Centers for Disease Control and Prevention (CDC) and American Academy of Pediatrics (AAP) differ. However, previous research has shown that consumption of breast milk in early life confers immunity against several infectious diseases. Evidence-based recommendations for any guidelines require research and clinical studies. The goals of this research are to address this gap and determine if breast milk consumption can confer immunity. These goals will be met through the following specific aims. Specific Aim 1. Detect and quantify SARS-CoV-2 IgM/IgG/IgA antibodies that are present in breast milk and saliva from mother/infant dyads over 6 months. Specific Aim 2. Detect the presence of neutralizing antibodies in breast milk and saliva samples from mother/infant dyads. Specific Aim 3. Determine if and how consumption of breast milk from a COVID-19 positive mother affects SARS-CoV-2 infection, progression and possible recurrence in their infants.
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COVID_Breastfeeding with COVID 19 disease: SARS-CoV-2 antibodies in breast milk and disease progression in the first six months of life
  • 批准号:
    10303486
  • 项目类别:
  • 资助金额:
    $27.31万
  • 财政年份:
    2021
  • 负责人:
    Sahira Askari Long
  • 依托单位:
海外基金