Pathology Core

病理学核心

• 批准号: 10434860
• 负责人: Yuri Fedoriw
• 金额: $ 7.49万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-13 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10434860
• 关键词: AIDS related cancer; Address; Africa South of the Sahara; Area; Clinical Research; Collaborations; Country; Cytology Histology; Data; Development; Diagnosis; Diagnostic; Diagnostic Services; Disease; Ensure; Faculty; Foundations; Future; Geographic Locations; Goals; HIV; Histology; Hospitals; Human; Income; Infrastructure; Institution; Journals; Kaposi Sarcoma; Knowledge; Laboratories; Logistics; Lymphoma; Malawi; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Mentors; Multicenter Studies; Pathologist; Pathology; Patient Selection; Patient-Focused Outcomes; Phase; Procedures; Process; Prognosis; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Services; Site; South Africa; Standardization; System; Telepathology; Time; Tissues; Training; Training and Education; Translational Research; United States; United States National Institutes of Health; Universities; Work; anticancer research; base; cancer care; cancer diagnosis; clinical care; cost effective; diagnostic tool; histological specimens; improved; innovation; low and middle-income countries; meetings; multidisciplinary; next generation; personalized medicine; prognostication; recruit; screening; skills; symposium; targeted treatment; working group

ABSTRACT: PATHOLOGY CORE Tissue diagnosis is essential for cancer care and research, and addressing HIV-related malignancies in Malawi and South Africa will be critically dependent on ensuring reliable access to robust pathology services. Achieving this requires strategic and multidisciplinary coordination of human and material resources for diagnostic pathology over time, as well as across geographic sites and scientific projects. This is a difficult undertaking even in high-income countries, and logistical challenges are significantly amplified in low- and middle-income countries. Initiatives to improve cancer care and research in SSA require accurate, cost- effective, and data-driven approaches to tissue acquisition and diagnosis, and strong regional pathology networks are an essential foundation to ultimately improve patient outcomes and conduct impactful research. Recognizing this, the UNC-Malawi-South Africa Cancer Consortium (UMSACC) will establish a shared- resource Pathology Core. The core will comprise of investigators from UNC Chapel Hill, UNC Project-Malawi and Kamuzu Central Hospital in Malawi, the University of the Witwatersrand, South Africa and Stellenbosch University, South Africa. The Pathology core will provide advanced and comprehensive diagnostic support to the multi-institutional research projects in this proposal through development of a central pathology review process, establish working groups within specific disease areas to actively identify regional best practices, and train the next generation of pathologists.

摘要：病理学核心 组织诊断对于马拉维的癌症护理和研究以及解决艾滋病毒相关恶性肿瘤至关重要 南非将严重依赖于确保可靠地获得强大的病理学服务。 要做到这一点，就需要对人力和物力资源进行战略性和多学科的协调， 诊断病理学随着时间的推移，以及跨地理位置和科学项目。这是一个艰难 即使在高收入国家，物流挑战也在低收入国家和 中等收入国家。改善SSA癌症护理和研究的举措需要准确的，成本- 有效的数据驱动的组织采集和诊断方法，以及强大的区域病理学 网络是最终改善患者预后和开展有影响力研究的重要基础。 认识到这一点，联合国大学-马拉维-南非癌症联合会将建立一个共享的- 病理学核心资源核心将由来自北卡罗来纳大学查佩尔山、北卡罗来纳大学马拉维项目的调查员组成 和马拉维的卡穆祖中央医院、南非威特沃特斯兰德大学和斯泰伦博斯 大学，南非。病理学核心将提供先进和全面的诊断支持， 通过发展中央病理学审查， 在特定疾病领域内建立工作组，积极确定区域最佳做法， 培养下一代病理学家