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Advancing Stroke Care: An intraarterial stem cell delivery system

推进中风护理：动脉内干细胞输送系统

基本信息

批准号：
10073703
负责人：
金额：
$ 4.96万
依托单位：
ENGINEURO LTD
依托单位国家：
英国
项目类别：
Grant for R&D
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=10073703
关键词：
Advancing Stroke Care intraarterial stem

项目摘要

Stroke is a grave medical emergency that arises when the blood supply to the brain is disrupted or reduced, ultimately leading to the demise of brain cells. It is a global leading cause of mortality and long-term disability, with over 100,000 cases diagnosed annually in the United Kingdom alone - meaning a stroke victim is reported every five minutes. Shockingly, more than 1.3 million stroke survivors are currently living in the UK, coping with the most extensive range of impairments presented by any disease. The National Health Service in the UK allocates an astonishing £3 billion annually towards stroke treatment and management, with an additional £4 billion economic cost due to stroke-related disability, lost productivity, and informal care.The focus of our project is to develop a ground-breaking solution for delivering stem cells to the brain following a stroke, which is a major global health issue leading to fatalities and disabilities. The recovery of stroke patients could be revolutionised by exploring stem cell therapy; however, the challenge lies in finding a way to accurately deliver the stem cells to the affected area of the brain, as current methods are inefficient and carry high risks. Our team aims to create a cutting-edge method of delivery that uses a microcatheter guided by imaging techniques to deliver stem cells and medication directly to the damaged part of the brain, ensuring precision and safety. The successful implementation of our innovative approach could potentially be extended to other medical fields, including cardiac repair and cancer immunotherapy.

中风是一种严重的医疗紧急情况，当大脑的血液供应中断或减少，最终导致脑细胞死亡时，就会出现中风。它是导致死亡和长期残疾的全球主要原因，仅在英国每年就有超过10万例确诊病例-这意味着每五分钟就有一名中风患者被报告。令人震惊的是，超过130万中风幸存者目前生活在英国，正在应对任何疾病带来的最广泛的损害。英国国家医疗服务体系每年用于中风治疗和管理的资金高达30亿GB，另有40亿GB的经济成本因中风相关的残疾、生产力丧失和非正式护理而增加。我们项目的重点是开发一种突破性的解决方案，将干细胞输送到中风后的大脑，这是导致死亡和残疾的主要全球健康问题。通过探索干细胞疗法，中风患者的康复可能会发生革命性的变化；然而，挑战在于找到一种方法，将干细胞准确地输送到大脑的受影响区域，因为目前的方法效率低下，风险很高。我们团队的目标是创造一种尖端的给药方法，使用成像技术引导的微导管将干细胞和药物直接输送到大脑受损部分，确保精确度和安全性。我们创新方法的成功实施可能会扩展到其他医学领域，包括心脏修复和癌症免疫治疗。